ChEMBL ligand: CHEMBL1258006 (ATA-101, Bradaniclina, Bradanicline, TC 5619, TC-5619)
5-HT3A/5-hydroxytryptamine receptor 3A in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] There should be some charts here, you may need to enable JavaScript!
Acetylcholine-binding protein in Lymnaea stagnalis [ChEMBL: CHEMBL6084] [UniProtKB: P58154] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor subunit alpha-7 in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor subunit alpha-7 in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] There should be some charts here, you may need to enable JavaScript!
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT3A/5-hydroxytryptamine receptor 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL	Inhibition of human 5HT3R	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]
Acetylcholine-binding protein in Lymnaea stagnalis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6084] [UniProtKB: P58154]
ChEMBL	Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assay	B	7.7	pKd	19.95	nM	Kd	J Med Chem (2010) 53: 7192-7201 [PMID:20828128]
ChEMBL	Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system	B	7.84	pKi	14.45	nM	Ki	J Med Chem (2010) 53: 7192-7201 [PMID:20828128]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
ChEMBL	Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranes	B	5.77	pKi	1700	nM	Ki	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]
nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390]
ChEMBL	Displacement of [3H]nicotine alpha4beta2 nAChR in rat cortical membranes	B	5.68	pKi	2100	nM	Ki	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor subunit alpha-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL	Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells	B	8.56	pKi	2.75	nM	Ki	J Med Chem (2010) 53: 7192-7201 [PMID:20828128]
ChEMBL	Binding affinity to human alpha7 nAChR expressed in HEK293 cells co-expressing RIC3 cDNA	B	9	pKi	1	nM	Ki	J Med Chem (2011) 54: 7943-7961 [PMID:21919481]
ChEMBL	Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cells	B	9	pKi	1	nM	Ki	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]
ChEMBL	Agonist activity at human alpha7 nAChR expressed in Xenopus oocyte	F	7.48	pEC50	33	nM	EC50	J Med Chem (2011) 54: 7943-7961 [PMID:21919481]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor subunit alpha-7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
ChEMBL	Binding affinity to alpha7 nAChR in rat hippocampal membranes	B	9	pKi	1	nM	Ki	J Med Chem (2011) 54: 7943-7961 [PMID:21919481]
ChEMBL	Displacement of [3H]methyllycaconitine form alpha7 nAchR in rat hippocampal membranes	B	9.38	pKi	0.42	nM	Ki	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]
ChEMBL	Agonist activity at rat alpha7 nAchR expressed in GH4C1 cells by whole cell patch clamp assay	F	7.77	pEC50	17	nM	EC50	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells by whole cell voltage clamp assay	B	4.27	pIC50	54000	nM	IC50	J Med Chem (2012) 55: 9793-9809 [PMID:23126648]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]