donitriptan [Ligand Id: 39] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1742428 (Donitriptan, F-11356)
  • 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
  • This target only has 1 pki data point
  • 7.6
1 CHEMBL1742428_lig_chart_1 5-HT1A receptor Human
There should be some charts here, you may need to enable JavaScript!
  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
  • 5-HT1B receptor in Rat [GtoPdb: 2] [UniProtKB: P28564]
  • 9.7
2 CHEMBL1742428_lig_chart_2 5-HT1B receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
  • 5-HT1D receptor in Rat [GtoPdb: 3] [UniProtKB: P28565]
  • 9.6
3 CHEMBL1742428_lig_chart_3 5-HT1D receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
  • 5.9
4 CHEMBL1742428_lig_chart_4 5-ht1e receptor Human
There should be some charts here, you may need to enable JavaScript!
  • 5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
  • This target only has 1 pki data point
  • 5.5
5 CHEMBL1742428_lig_chart_5 5-HT1F receptor Human
There should be some charts here, you may need to enable JavaScript!
  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
  • 6.7
6 CHEMBL1742428_lig_chart_6 5-HT2A receptor Human
There should be some charts here, you may need to enable JavaScript!
  • 5-HT5A receptor in Human [GtoPdb: 10] [UniProtKB: P47898]
  • This target only has 1 pki data point
  • 6.1
7 CHEMBL1742428_lig_chart_7 5-HT5A receptor Human
There should be some charts here, you may need to enable JavaScript!
  • 5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
  • This target only has 1 pki data point
  • 5.6
8 CHEMBL1742428_lig_chart_8 5-HT6 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 7.6 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 9.4 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT1B receptor in Rat [GtoPdb: 2] [UniProtKB: P28564]
GtoPdb - - 9.7 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 9.3 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT1D receptor in Rat [GtoPdb: 3] [UniProtKB: P28565]
GtoPdb - - 9.6 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
GtoPdb - - 5.9 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
GtoPdb - - 5.5 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 6.7 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT5A receptor in Human [GtoPdb: 10] [UniProtKB: P47898]
GtoPdb - - 6.1 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb - - 5.6 pKi - - - J Pharmacol Exp Ther (1999) 290: 83-95 [PMID:10381763]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]