[3H]L365260 [Ligand Id: 3477] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL289498
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
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  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
  • CCK2 receptor/Cholecystokinin B receptor in Rat [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
ChEMBL Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreas B 8.09 pIC50 8.1 nM IC50 J Med Chem (1989) 32: 13-16 [PMID:2909725]
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
GtoPdb - - 8.5 pKd 2.9 nM Kd Regul Pept (2002) 103: 29-37 [PMID:11738246]
ChEMBL Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex B 8.15 pIC50 7.1 nM IC50 J Med Chem (1989) 32: 13-16 [PMID:2909725]
ChEMBL Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin) B 8.28 pIC50 5.2 nM IC50 Medchemcomm (2017) 8: 1561-1574 [PMID:30108868]
ChEMBL Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands B 8.51 pIC50 3.1 nM IC50 J Med Chem (1989) 32: 13-16 [PMID:2909725]
CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
ChEMBL Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method B 8.42 pIC50 3.8 nM IC50 Medchemcomm (2017) 8: 1561-1574 [PMID:30108868]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]