27-hydroxycholesterol [Ligand Id: 2752] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL353882
  • Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
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  • GPR183 in Human [GtoPdb: 81] [UniProtKB: P32249]
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  • Liver X receptor-β in Human [GtoPdb: 601] [UniProtKB: P55055]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL Concentration required for half maximal activity was calculated in human nuclear oxysterol receptor liver X receptor-alpha in LiSA. B 6.6 pEC50 250 nM EC50 J. Med. Chem. (2001) 44: 886-897 [PMID:11300870]
GtoPdb - - 7.1 pEC50 - - - J. Biol. Chem. (2001) 276: 38378-87 [PMID:11504730]
GPR183 in Human [GtoPdb: 81] [UniProtKB: P32249]
GtoPdb - - 5.52 pEC50 3029 nM EC50 Nature (2011) 475: 519-23 [PMID:21796211]
Liver X receptor-β in Human [GtoPdb: 601] [UniProtKB: P55055]
GtoPdb - - 7.15 pEC50 - - - J. Biol. Chem. (2001) 276: 38378-87 [PMID:11504730]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]