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ChEMBL ligand: CHEMBL339427 (D-tubocurarine, Tubocurarine, Tubocurarine cation, Tubocurarine ion) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8] | ||||||||
ChEMBL | Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay | B | 5.03 | pIC50 | 9400 | nM | IC50 | J Med Chem (2013) 56: 781-795 [PMID:23241029] |
MATE2/Multidrug and toxin extrusion protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8] | ||||||||
ChEMBL | Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay | B | 4.26 | pIC50 | 55500 | nM | IC50 | J Med Chem (2013) 56: 781-795 [PMID:23241029] |
Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4] | ||||||||
ChEMBL | Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting | B | 5.73 | pKi | 1880 | nM | Ki | J Pestic Sci (1992) 17: 231-236 |
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] | ||||||||
ChEMBL | Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay | B | 4.1 | pIC50 | 78800 | nM | IC50 | J Med Chem (2013) 56: 781-795 [PMID:23241029] |
5-HT3AB in Human [GtoPdb: 378] | ||||||||
GtoPdb | - | - | 4.5 | pKi | - | - | - | Neuropharmacology (2001) 41: 282-4 [PMID:11489465] |
5-HT3A in Human [GtoPdb: 379] | ||||||||
GtoPdb | - | - | 4.8 | pKi | - | - | - |
Neuropharmacology (2001) 41: 282-4 [PMID:11489465]; Br J Pharmacol (1996) 118: 1237-45 [PMID:8818349] |
5-HT3A in Mouse [GtoPdb: 379] | ||||||||
GtoPdb | - | - | 7.1 | pKi | - | - | - |
J Neurochem (1995) 65: 104-10 [PMID:7790853]; Neuropharmacology (1998) 37: 251-7 [PMID:9680250] |
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952] | ||||||||
GtoPdb | - | - | 4.6 | pIC50 | 25000 | nM | IC50 |
Science (1996) 273: 1709-14 [PMID:8781233]; Br J Pharmacol (2000) 129: 627-30 [PMID:10683185]; Br J Pharmacol (2000) 129: 991-9 [PMID:10696100] |
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
GtoPdb | - | - | 5.7 | pIC50 | - | - | - | FEBS Lett (2000) 469: 196-202 [PMID:10713270] |
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] | ||||||||
GtoPdb | - | - | 5.6 | pIC50 | - | - | - |
Science (1996) 273: 1709-14 [PMID:8781233]; Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]; J Biol Chem (1997) 272: 23195-200 [PMID:9287325] |
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6] | ||||||||
GtoPdb | - | - | 4.5 | pIC50 | - | - | - |
Neuropharmacology (2001) 40: 772-83 [PMID:11369031]; Mol Pharmacol (2004) 65: 788-801 [PMID:14978258] |
ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2] | ||||||||
GtoPdb | - | - | 5.2 | pIC50 | 6300 | nM | IC50 | J Biol Chem (2003) 278: 712-7 [PMID:12381728] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]