octopamine [Ligand Id: 2149] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL53929 (ND 50, ND-50, NSC-757399, Octopamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay | B | 7.62 | pEC50 | 24 | nM | EC50 | Nature (2007) 450: 553-556 [PMID:18033297] |
| TA1 receptor in Human [GtoPdb: 364] [UniProtKB: Q96RJ0] | ||||||||
| GtoPdb | - | - | 5.8 | pEC50 | - | - | - |
Proc Natl Acad Sci USA (2001) 98: 8966-71 [PMID:11459929]; Mol Pharmacol (2008) 74: 585-594 [PMID:18524885]; J Pharmacol Exp Ther (2007) 320: 475-85 [PMID:17038507]; Biochem J (2009) 424: 39-45 [PMID:19725810]; PLoS ONE (2011) 6: e27073 [PMID:22073124] |
| TA1 receptor in Mouse [GtoPdb: 364] [UniProtKB: Q923Y8] | ||||||||
| GtoPdb | - | - | 5.8 | pEC50 | - | - | - |
Genes Brain Behav (2007) 6: 628-39 [PMID:17212650]; Biochem J (2009) 424: 39-45 [PMID:19725810] |
| TA1 receptor/Trace amine-associated receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9] | ||||||||
| ChEMBL | Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr | F | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (2017) 60: 2605-2628 [PMID:28244748] |
| GtoPdb | - | - | 5.9 | pEC50 | - | - | - | Mol Pharmacol (2001) 60: 1181-8 [PMID:11723224] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
