U46619 [Ligand Id: 1888] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL521784
  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
  • TP receptor in Mouse [GtoPdb: 346] [UniProtKB: P30987]
Created with Highcharts 10.3.3ValuesChart context menuThromboxane A2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse0246810Highcharts.com
  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
Created with Highcharts 10.3.3ValuesChart context menuDP1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
Created with Highcharts 10.3.3ValuesChart context menuDP2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
  • EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
Created with Highcharts 10.3.3ValuesChart context menuEP1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
Created with Highcharts 10.3.3ValuesChart context menuEP2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • EP3 receptor in Human [GtoPdb: 342] [UniProtKB: P43115]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
Created with Highcharts 10.3.3ValuesChart context menuEP3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
Created with Highcharts 10.3.3ValuesChart context menuEP4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
  • FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
Created with Highcharts 10.3.3ValuesChart context menuFP receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse02468Highcharts.com
  • IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
Created with Highcharts 10.3.3ValuesChart context menuIP receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
GtoPdb - - 7.5 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
ChEMBL Displacement of [3H]SQ29548 from thromboxane A2 receptor B 8.26 pKi 5.5 nM Ki J Nat Prod (1993) 56: 441-455 [PMID:8496700]
TP receptor in Mouse [GtoPdb: 346] [UniProtKB: P30987]
GtoPdb - - 7.2 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 5.9 pKi - - - Br J Pharmacol (1998) 123: 1317-24 [PMID:9579725];
Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 5.5 pKi - - - Br J Pharmacol (2002) 137: 1163-72 [PMID:12466225]
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 4.5 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb - - 5.2 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 4.9 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 5.1 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP3 receptor in Human [GtoPdb: 342] [UniProtKB: P43115]
GtoPdb - - 4.9 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 4.79 pKi 16200 nM Ki Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 6.83 pEC50 149 nM EC50 Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 5.7 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
GtoPdb - - 5.6 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb - - 6.6 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
GtoPdb - - 6 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 4.2 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]