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ChEMBL ligand: CHEMBL153254 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
GtoPdb | - | - | 7.1 | pKi | - | - | - | Biochem Pharmacol (2004) 68: 1995-2002 [PMID:15476670] |
ChEMBL | Displacement of [3H]MRS-2270 from human P2Y1 receptor expressed in Sf9 cells | B | 7.12 | pKi | 76 | nM | Ki | J Med Chem (2007) 50: 3229-3241 [PMID:17564423] |
ChEMBL | Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeS-ADP-induced inositol phosphate formation | F | 6.21 | pIC50 | 620 | nM | IC50 | J Med Chem (2007) 50: 3229-3241 [PMID:17564423] |
ChEMBL | Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeS-ADP-stimulated PLC activity | F | 6.21 | pIC50 | 616.6 | nM | IC50 | J Med Chem (2007) 50: 3229-3241 [PMID:17564423] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]