BNTX [Ligand Id: 1634] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL101519 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| ChEMBL | Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DPDPE from Opioid receptor delta 1 | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1997) 40: 749-753 [PMID:9057861] |
| ChEMBL | Tested for binding activity against Opioid receptor delta 2 using [3H]DSLET ligand | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| δ receptor in Mouse [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Mol Pharmacol (1994) 45: 330-4 [PMID:8114680] |
| δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
| ChEMBL | Binding affinity evaluated by inhibition of binding of [3H]DADLE to delta opioid receptor of rat brain | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 357-362 [PMID:10091684] |
| GtoPdb | - | - | 8.7 | pKi | - | - | - | Br J Pharmacol (1999) 128: 556-62 [PMID:10516632] |
| ChEMBL | Tested for binding activity against Opioid receptor delta 1 using [3H]DPDPE ligand | B | 9.08 | pKi | 0.83 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
| ChEMBL | Tested for binding activity against kappa opioid receptor using [3H]U-69593 ligand | B | 7.18 | pKi | 66 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| ChEMBL | Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]U-69593 from Opioid receptor kappa 1 | B | 7.47 | pKi | 34 | nM | Ki | J Med Chem (1997) 40: 749-753 [PMID:9057861] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Tested for binding activity against mu opioid receptor using [3H]DAMGO ligand | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| GtoPdb | - | - | 8.8 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
| ChEMBL | Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DAMGO from Opioid receptor mu 1 | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (1997) 40: 749-753 [PMID:9057861] |
| κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
