[3H]LY334370 [Ligand Id: 151] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL101690 (LY-334370) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5HT1A receptor (unknown origin) | B | 7.66 | pKi | 22.1 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 4337-4341 [PMID:26271587] |
| ChEMBL | In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1A receptor | B | 7.66 | pKi | 22 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1A receptor | B | 7.66 | pKi | 22 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1B receptor | B | 6.62 | pKi | 240 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1B receptor | B | 6.62 | pKi | 240 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| ChEMBL | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting | B | 7.08 | pKi | 83 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor | B | 6.37 | pKi | 430 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1D receptor | B | 6.37 | pKi | 430 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| ChEMBL | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting | B | 6.86 | pKi | 137 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
| 5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
| GtoPdb | - | - | 9.4 | pKd | 0.4 | nM | Kd | Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510] |
| ChEMBL | In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1F receptor | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| ChEMBL | Binding affinity to human 5HT1F receptor by radioligand binding assay | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 4337-4341 [PMID:26271587] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1F receptor | B | 8.8 | pKi | 1.6 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 167-170 [PMID:14684321] |
| ChEMBL | Binding affinity at human 5HT1F receptor | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
