nefextinib [Ligand Id: 13213] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297470 (Max-40279, MAX-40279) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| GtoPdb | Inhibitor potency for FLT3-ITD fusion | - | 9.47 | pIC50 | 0.34 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| GtoPdb | Inhibition potency for WT FLT3 | - | 9.55 | pIC50 | 0.28 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| GtoPdb | Inhibitor potency for FLT3 D835Y mutant | - | 9.7 | pIC50 | 0.2 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| GtoPdb | - | - | 8.26 | pIC50 | 5.5 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| GtoPdb | - | - | 8.22 | pIC50 | 6 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
| YES proto-oncogene 1, Src family tyrosine kinase in Human [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| GtoPdb | - | - | 8.24 | pIC50 | 5.8 | nM | IC50 | CN106366093A. Fused pyrimidine compound, and intermediate, preparation method, composition and application of (2017) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
