Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
GtoPdb | Inhibitin of WT TRKA | - | 7.3 | pKi | 50 | nM | Ki | US11542278. Heteroaromatic macrocyclic ether chemotherapeutic agents (2023) |
c-ros oncogene 1, receptor tyrosine kinase in Human [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
GtoPdb | Inhibition of ROS1G2032R | - | 7.3 | pKi | <50 | nM | Ki | US11542278. Heteroaromatic macrocyclic ether chemotherapeutic agents (2023) |
GtoPdb | Inhibition of wild-type ROS1 in an enzyme activity assay | - | 9.15 | pIC50 | 0.7 | nM | IC50 | Cancer Discov (2023) 13: 598-615 [PMID:36511802] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.