SA-57 [Ligand Id: 11815] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL457918
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
  • Fatty acid amide hydrolase in Mouse [GtoPdb: 1400] [UniProtKB: O08914]
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  • Monoacylglycerol lipase in Human [GtoPdb: 1399] [UniProtKB: Q99685]
  • Monoacylglycerol lipase in Mouse [GtoPdb: 1399] [UniProtKB: O35678]
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  • αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL Inhibition of FAAH B 7.89 pIC50 13 nM IC50 J Med Chem (2008) 51: 7327-7343 [PMID:18983142]
GtoPdb - - 8.72 pIC50 1.9 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
Fatty acid amide hydrolase in Mouse [GtoPdb: 1400] [UniProtKB: O08914]
GtoPdb - - 8.49 pIC50 3.2 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
Monoacylglycerol lipase in Human [GtoPdb: 1399] [UniProtKB: Q99685]
GtoPdb - - 5.85 pIC50 1400 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
Monoacylglycerol lipase in Mouse [GtoPdb: 1399] [UniProtKB: O35678]
GtoPdb - - 6.39 pIC50 410 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
GtoPdb - - 6.19 pIC50 650 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]