SA-57 [Ligand Id: 11815] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL457918
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
  • Fatty acid amide hydrolase in Mouse [GtoPdb: 1400] [UniProtKB: O08914]
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  • Monoacylglycerol lipase in Human [GtoPdb: 1399] [UniProtKB: Q99685]
  • Monoacylglycerol lipase in Mouse [GtoPdb: 1399] [UniProtKB: O35678]
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  • αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL Inhibition of FAAH B 7.89 pIC50 13 nM IC50 J. Med. Chem. (2008) 51: 7327-7343 [PMID:18983142]
GtoPdb - - 8.72 pIC50 1.9 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
Fatty acid amide hydrolase in Mouse [GtoPdb: 1400] [UniProtKB: O08914]
GtoPdb - - 8.49 pIC50 3.2 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
Monoacylglycerol lipase in Human [GtoPdb: 1399] [UniProtKB: Q99685]
GtoPdb - - 5.85 pIC50 1400 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
Monoacylglycerol lipase in Mouse [GtoPdb: 1399] [UniProtKB: O35678]
GtoPdb - - 6.39 pIC50 410 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]
αβ-Hydrolase 6 in Mouse [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
GtoPdb - - 6.19 pIC50 650 nM IC50 ACS Chem Neurosci (2012) 3: 418-26 [PMID:22860211]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]