lunacalcipol [Ligand Id: 11382] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2105705 (CTA-018, CTA018, Lunacalcipol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP24A1/Cytochrome P450 24A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4521] [GtoPdb: 1365] [UniProtKB: Q07973] | ||||||||
| ChEMBL | Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reductase and NADPH incubated at 37 degC for 25 mins by HPLC method | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2014) 57: 7702-7715 [PMID:25148392] |
| GtoPdb | - | - | 7.6 | pIC50 | - | - | - | J Steroid Biochem Mol Biol (2010) 121: 13-9 [PMID:20347976] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
