ISAM-140 [Ligand Id: 11223] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3787197 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Displacement of [3H]DPCPX from human recombinant A1 receptor expressed in CHOA1 cell membranes incubated for 60 mins by radioligand binding competition assay | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2019) 62: 9315-9330 [PMID:31557025] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Displacement of [3H]ZM241385 from human recombinant A2A receptor expressed in human HeLa cell membranes incubated for 30 mins by radioligand binding competition assay | B | 7.55 | pKi | 28 | nM | Ki | J Med Chem (2019) 62: 9315-9330 [PMID:31557025] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins | B | 8.46 | pKi | 3.49 | nM | Ki | J Med Chem (2016) 59: 1967-1983 [PMID:26824742] |
| ChEMBL | Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay | B | 8.46 | pKi | 3.49 | nM | Ki | J Med Chem (2019) 62: 9315-9330 [PMID:31557025] |
| ChEMBL | Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method | B | 8.46 | pKi | 3.49 | nM | Ki | J Med Chem (2020) 63: 7721-7739 [PMID:32573250] |
| ChEMBL | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method | B | 8.46 | pKi | 3.49 | nM | Ki | J Med Chem (2021) 64: 458-480 [PMID:33372800] |
| GtoPdb | - | - | 8.46 | pKi | 3.49 | nM | Ki | J Med Chem (2016) 59: 1967-83 [PMID:26824742] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Displacement of [3H]NECA from human A3 receptor expressed in human HeLa cell membranes incubated for 180 mins by radioligand binding competition assay | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2019) 62: 9315-9330 [PMID:31557025] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
