C1-27 [Ligand Id: 10719] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4210652
  • glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
ChEMBL Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione as substrate preincubated for 1 to 6 mins followed by substrate addition by spectrophotmetric analysis B 6.36 pKi 440 nM Ki J Med Chem (2020) 63: 2894-2914 [PMID:32105470]
ChEMBL Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli using S-(4-nitrophenacyl)glutathione as substrate preincubated for 2 mins followed by substrate addition by 4-NPG assay B 6.89 pIC50 130 nM IC50 J Med Chem (2020) 63: 2894-2914 [PMID:32105470]
GtoPdb - - 6.89 pIC50 130 nM IC50 J Med Chem (2020) 63: 2894-2914 [PMID:32105470]
ChEMBL Inhibition of GSTO1-1 (unknown origin) by enzymatic assay B 7.51 pIC50 31 nM IC50 J Med Chem (2018) 61: 7448-7470 [PMID:29652143]
ChEMBL Inhibition of CMFDA binding to human N-terminal 6x-His-tagged GSTO1-1 preincubated for 30 mins followed by CMFDA addition and measured after 30 mins by in-gel fluorescence binding assay B 7.68 pIC50 21 nM IC50 J Med Chem (2019) 62: 3068-3087 [PMID:30735370]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]