butyric acid [Ligand Id: 1059] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL14227 (Butanoic acid, Butyrate, Butyric acid, Butyricum acidum, FEMA NO. 2221, N-butanoic acid, N-butyric acid, Normal butyric acid, NSC-8415) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843] | ||||||||
| GtoPdb | - | - | 4.9 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; J Biol Chem (2003) 278: 25481-9 [PMID:12711604]; Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361]; J Biol Chem (2011) 286: 10628-40 [PMID:21220428] |
| ChEMBL | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method | F | 4.92 | pEC50 | 12000 | nM | EC50 | J Med Chem (2018) 61: 47-61 [PMID:28745893] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC1 | B | 4.8 | pIC50 | 16000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
| GtoPdb | - | - | 4.8 | pIC50 | 16000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| GtoPdb | - | - | 4.92 | pIC50 | 12000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
| ChEMBL | Inhibition of human recombinant HDAC2 | B | 4.92 | pIC50 | 12000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC3 | B | 5.05 | pIC50 | 9000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
| GtoPdb | - | - | 5.05 | pIC50 | 9000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| GtoPdb | - | - | 4.82 | pIC50 | 15000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
| ChEMBL | Inhibition of human recombinant HDAC8 | B | 4.82 | pIC50 | 15000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
| OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] | ||||||||
| ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.09 | pKi | 82000 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
| ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.09 | pKi | 81283.05 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
| FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552] | ||||||||
| GtoPdb | - | - | 4.6 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; Biochem Biophys Res Commun (2003) 303: 1047-52 [PMID:12684041]; J Biol Chem (2003) 278: 25481-9 [PMID:12711604]; J Biol Chem (2011) 286: 10628-40 [PMID:21220428] |
| HCA2 receptor in Human [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
| GtoPdb | - | - | 2.8 | pEC50 | - | - | - | |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
