compound 5 [PMID: 30894487] [Ligand Id: 10398] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3989220 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.29 | pEC50 | 510 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite stage V gametocyte assay | - | 5 | pEC50 | 9900 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| GtoPdb | Parasite gamete formation assay | - | 6 | pEC50 | >1000 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| GtoPdb | Parasite growth inhibition assay | - | 6.41 | pEC50 | 390 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium vivax [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 6.02 | pEC50 | 950 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3059] [UniProtKB: Q8IDJ8] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.57 | pEC50 | 270 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
