compound 5 [PMID: 30894487] [Ligand Id: 10398] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3989220
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium vivax [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 6.29 pEC50 510 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059]
GtoPdb Parasite stage V gametocyte assay - 5 pEC50 9900 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
GtoPdb Parasite gamete formation assay - 6 pEC50 >1000 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
GtoPdb Parasite growth inhibition assay - 6.41 pEC50 390 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium vivax [GtoPdb: 3059]
GtoPdb Parasite liver stage assay - 6.02 pEC50 950 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
GtoPdb Parasite growth inhibition assay - 6.57 pEC50 270 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]