compound 5 [PMID: 30894487] [Ligand Id: 10398] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3989220 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.29 | pEC50 | 510 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite stage V gametocyte assay | - | 5 | pEC50 | 9900 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| GtoPdb | Parasite gamete formation assay | - | 6 | pEC50 | >1000 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| GtoPdb | Parasite growth inhibition assay | - | 6.41 | pEC50 | 390 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium vivax [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 6.02 | pEC50 | 950 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3059] [UniProtKB: Q8IDJ8] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.57 | pEC50 | 270 | nM | EC50 | Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
