compound 17l [PMID: 26288691] [Ligand Id: 10035] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3623107
  • Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL Antagonist activity at human LXR-alpha transfected in HEK293 cells after 16 hrs by luciferase reporter gene assay in presence of 0.3 uM N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide B 5.48 pIC50 3300 nM IC50 ACS Med. Chem. Lett. (2015) 6: 902-907 [PMID:26288691]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL Antagonist activity at human LXR-beta transfected in HEK293 cells after 16 hrs by luciferase reporter gene assay in presence of 0.1 uM N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide B 5.37 pIC50 4300 nM IC50 ACS Med. Chem. Lett. (2015) 6: 902-907 [PMID:26288691]
GtoPdb Binding affinity to LXRβ ligand binding domain by TR-FRET assay. - 5.74 pIC50 1800 nM IC50 ACS Med Chem Lett (2015) 6: 902-7 [PMID:26288691]
ChEMBL Binding affinity to LXR-beta ligand binding domain (unknown origin) by TR-FRET assay in presence of 0.1 uM agonist N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide B 5.74 pIC50 1800 nM IC50 ACS Med. Chem. Lett. (2015) 6: 902-907 [PMID:26288691]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]