GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
G protein-coupled receptors
Download the list of all GPCR targets in CSV format 
| Class Frizzled GPCRs | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Class Frizzled GPCRs |
Wnt-1
{Sp: Human}
Wnt-2 {Sp: Human} Wnt-5a {Sp: Human} Wnt-3a {Sp: Human} Wnt-7b {Sp: Human} |
FZD1 |
FZD1 |
Fzd1 |
Fzd1 |
|
| Class Frizzled GPCRs |
Wnt-5a
{Sp: Human}
|
FZD2 |
FZD2 |
Fzd2 |
Fzd2 |
|
| Class Frizzled GPCRs | FZD3 |
FZD3 |
Fzd3 |
Fzd3 |
The is some evidence for Wnt-5a and Wnt-3 binding to the receptor | |
| Class Frizzled GPCRs |
norrin
{Sp: Mouse}
Wnt |
FZD4 |
FZD4 |
Fzd4 |
Fzd4 |
|
| Class Frizzled GPCRs | WNTs | FZD5 |
FZD5 |
Fzd5 |
Fzd5 |
|
| Class Frizzled GPCRs |
Wnt-4
{Sp: Human}
Wnt-5a {Sp: Human} Wnt-3a {Sp: Human} |
FZD6 |
FZD6 |
Fzd6 |
Fzd6 |
|
| Class Frizzled GPCRs | Wnt | FZD7 |
FZD7 |
Fzd7 |
Fzd7 |
|
| Class Frizzled GPCRs | Wnt | FZD8 |
FZD8 |
Fzd8 |
Fzd8 |
|
| Class Frizzled GPCRs | Wnt | FZD9 |
FZD9 |
Fzd9 |
Fzd9 |
|
| Class Frizzled GPCRs | Wnt | FZD10 |
FZD10 |
Fzd10 |
||
| Class Frizzled GPCRs | constitutive | SMO |
SMO |
Smo |
Smo |
|
