4A. Nerve growth factor IB-like receptors | Nuclear hormone receptors

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4A. Nerve growth factor IB-like receptors

4A. Nerve growth factor IB-like receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Nerve growth factor IB-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [3]) have yet to be officially paired with an endogenous ligand, although preliminary evidence suggests that they bind fatty acid metabolites and fatty acid mimetic drugs [2,4,6].

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

Nerve Growth factor IB / NR4A1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	629
Nomenclature	Nerve Growth factor IB
Systematic nomenclature	NR4A1
Previous and unofficial names	Gfrp \| GFRP1 \| Hbr1 \| immediate early gene transcription factor NGFI-B \| NAK1 \| nerve growth factor-induced protein I-B \| NGFIB \| nuclear receptor subfamily 4 \| NUR77 \| Orphan nuclear receptor HMR \| ST59 \| TIS1 \| TR3
Genes	NR4A1 (Hs), Nr4a1 (Mm), Nr4a1 (Rn)
Ensembl ID	ENSG00000123358 (Hs), ENSMUSG00000023034 (Mm), ENSRNOG00000007607 (Rn)
UniProtKB AC	P22736 (Hs), P12813 (Mm), P22829 (Rn)
Comment	An endogenous agonist, cytosporone B, has been described [8], although structural analysis and molecular modelling has not identified a ligand binding site [1,5,7].

Nuclear receptor related 1 / NR4A2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	630
Nomenclature	Nuclear receptor related 1
Systematic nomenclature	NR4A2
Previous and unofficial names	RNR1 \| Immediate early response protein NOT \| TINUR \| NUR-related factor 1 \| SL-322 \| nuclear orphan receptor HZF-3 \| orphan nuclear receptor NURR1 \| regenerating liver nuclear receptor 1 \| transcriptionally inducible nuclear receptor \| nuclear receptor subfamily 4
Genes	NR4A2 (Hs), Nr4a2 (Mm), Nr4a2 (Rn)
Ensembl ID	ENSG00000153234 (Hs), ENSMUSG00000026826 (Mm), ENSRNOG00000005600 (Rn)
UniProtKB AC	P43354 (Hs), Q06219 (Mm), Q07917 (Rn)

Neuron-derived orphan receptor 1 / NR4A3 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	631
Nomenclature	Neuron-derived orphan receptor 1
Systematic nomenclature	NR4A3
Previous and unofficial names	CHN \| MINOR \| mitogen-induced nuclear orphan receptor \| Neuron-derived orphan receptor \| NOR1 \| neuron-derived orphan receptor 1 \| neuron-derived orphan receptor 1/2 \| nuclear hormone receptor NOR-1/NOR-2 \| TEC \| CSMF \| nuclear receptor subfamily 4
Genes	NR4A3 (Hs), Nr4a3 (Mm), Nr4a3 (Rn)
Ensembl ID	ENSG00000119508 (Hs), ENSMUSG00000028341 (Mm), ENSRNOG00000005964 (Rn)
UniProtKB AC	Q92570 (Hs), Q9QZB6 (Mm), P51179 (Rn)

References

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1. Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ. (2003) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell, 113 (6): 731-42. [PMID:12809604]

2. Ballarotto M, Willems S, Stiller T, Nawa F, Marschner JA, Grisoni F, Merk D. (2023) De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J Med Chem, 66 (12): 8170-8177. [PMID:37256819]

3. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, 58 (4): 798-836. [PMID:17132856]

4. de Vera IM, Giri PK, Munoz-Tello P, Brust R, Fuhrmann J, Matta-Camacho E, Shang J, Campbell S, Wilson HD, Granados J et al.. (2016) Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1. ACS Chem Biol, 11 (7): 1795-9. [PMID:27128111]

5. Flaig R, Greschik H, Peluso-Iltis C, Moras D. (2005) Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain. J Biol Chem, 280 (19): 19250-8. [PMID:15716272]

6. Proschak E, Heitel P, Kalinowsky L, Merk D. (2017) Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery. J Med Chem, 60 (13): 5235-5266. [PMID:28252961]

7. Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T. (2003) Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature, 423 (6939): 555-60. [PMID:12774125]

8. Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC et al.. (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol, 4 (9): 548-56. [PMID:18690216]

How to cite this family page

Database page citation:

4A. Nerve growth factor IB-like receptors. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=99.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors. Br J Pharmacol. 180 Suppl 2:S223-240.