BTB (POZ) domain containing TFs

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BTB (POZ) domain containing TFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The BTB/POZ transcription factor family has four members, BCL6, Kaiso (ZBTB33), HIC1, and PLZF (ZBTB16). They all also belong to the much larger C2H2-type zinc finger transcription factor family.

Targets

Targets of relevance to immunopharmacology are highlighted in blue

BCL6 transcription repressor Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2957

Nomenclature

BCL6 transcription repressor

Previous and unofficial names

Genes

BCL6 (Hs), Bcl6 (Mm), Bcl6 (Rn)

Ensembl ID

ENSG00000113916 (Hs), ENSMUSG00000022508 (Mm), ENSRNOG00000001843 (Rn)

UniProtKB AC

P41182 (Hs), P41183 (Mm)

Inhibitors

JNJ-65234637 (Binding) pK_d 8.3 [1]

References

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How to cite this family page

Database page citation:

BTB (POZ) domain containing TFs. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=973.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.