2F. COUP-TF-like receptors | Nuclear hormone receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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2F. COUP-TF-like receptors

2F. COUP-TF-like receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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COUP-TF-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1-2]) have yet to be officially paired with an endogenous ligand.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

COUP-TF1 / NR2F1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	617
Nomenclature	COUP-TF1
Systematic nomenclature	NR2F1
Previous and unofficial names	COUPα \| EAR3 \| SVP44 \| ERBAL3 \| TFCOUP1 \| nuclear receptor subfamily 2
Genes	NR2F1 (Hs), Nr2f1 (Mm), Nr2f1 (Rn)
Ensembl ID	ENSG00000175745 (Hs), ENSMUSG00000069171 (Mm), ENSRNOG00000014795 (Rn)
UniProtKB AC	P10589 (Hs), Q60632 (Mm)
Comment	Gene disruption is perinatally lethal [4].

COUP-TF2 / NR2F2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	618
Nomenclature	COUP-TF2
Systematic nomenclature	NR2F2
Previous and unofficial names	ARP1 \| COUPβ \| COUP-TFII \| SVP40 \| NF-E3 \| apolipoprotein A-I regulatory protein 1 \| Aporp1 \| EAR3 \| ovalbumin upstream promoter beta nuclear receptor \| TFCOUP2 \| nuclear receptor subfamily 2
Genes	NR2F2 (Hs), Nr2f2 (Mm), Nr2f2 (Rn)
Ensembl ID	ENSG00000185551 (Hs), ENSMUSG00000030551 (Mm), ENSRNOG00000010308 (Rn)
UniProtKB AC	P24468 (Hs), P43135 (Mm), O09018 (Rn)
Comment	Gene disruption is embryonically lethal [3].

V-erbA-related gene / NR2F6 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	619
Nomenclature	V-erbA-related gene
Systematic nomenclature	NR2F6
Previous and unofficial names	EAR2 \| ERBAL2 \| COUPg \| orphan nuclear receptor EAR-2 \| ovalbumin upstream promoter gamma nuclear receptor rCOUPg \| V-erbA-related protein 2 \| V-erbA-related protein EAR-2 \| COUP-TF3 \| nuclear receptor subfamily 2
Genes	NR2F6 (Hs), Nr2f6 (Mm), Nr2f6 (Rn)
Ensembl ID	ENSG00000160113 (Hs), ENSMUSG00000002393 (Mm), ENSRNOG00000016892 (Rn)
UniProtKB AC	P10588 (Hs), Q922G8 (Mm), O09017 (Rn)
Comment	Gene disruption impairs CNS development [5].

References

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1. Alexander SPH, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br J Pharmacol, 176 Suppl 1: S229-S246. [PMID:31710718]

2. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, 58 (4): 798-836. [PMID:17132856]

3. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY. (1999) The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev, 13 (8): 1037-49. [PMID:10215630]

4. Qiu Y, Pereira FA, DeMayo FJ, Lydon JP, Tsai SY, Tsai MJ. (1997) Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev, 11 (15): 1925-37. [PMID:9271116]

5. Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G. (2005) Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Genes Dev, 19 (5): 614-25. [PMID:15741322]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Nuclear hormone receptors. Br J Pharmacol. 182: S242-S258.