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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
The type I high affinity IgE receptor (FCεRI) is crucial for the production of allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The FCεRII has a lower affinity for IgE.
FCεR1α (Fc fragment of IgE receptor Ia)
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FCεR1β (membrane spanning 4-domains A2)
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FCεR1γ (Fc fragment of IgE receptor Ig)
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FCεRII (Fc fragment of IgE receptor II)
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Database page citation:
Fc epsilon receptors. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=946.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.