3.5.1.2 Glutaminases

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3.5.1.2 Glutaminases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

glutaminase C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2891
Nomenclature	glutaminase
Previous and unofficial names	GLS1 \| glutaminase 1 \| GAC \| L-glutamine amidohydrolase \| glutaminase kidney isoform \| K-glutaminase \| Gls
Genes	GLS (Hs), Gls (Mm), Gls (Rn)
Ensembl ID	ENSG00000115419 (Hs), ENSMUSG00000026103 (Mm), ENSRNOG00000056246 (Rn)
UniProtKB AC	O94925 (Hs), D3Z7P3 (Mm), P13264 (Rn)
Comment	GLS is a mitochondrial phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia.

How to cite this family page

Database page citation:

3.5.1.2 Glutaminases. Accessed on 18/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=925.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.