3.5.1.2 Glutaminases

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3.5.1.2 Glutaminases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

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glutaminase C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2891
Nomenclature	glutaminase
Previous and unofficial names	GLS1 \| glutaminase 1 \| GAC \| L-glutamine amidohydrolase \| glutaminase kidney isoform \| K-glutaminase \| Gls
Genes	GLS (Hs), Gls (Mm), Gls (Rn)
Ensembl ID	ENSG00000115419 (Hs), ENSMUSG00000026103 (Mm), ENSRNOG00000056246 (Rn)
UniProtKB AC	O94925 (Hs), D3Z7P3 (Mm), P13264 (Rn)
Comment	GLS is a mitochondrial phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia.

How to cite this family page

Database page citation:

3.5.1.2 Glutaminases. Accessed on 15/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=925.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.