Heat shock proteins

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Heat shock proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Targets

Targets of relevance to immunopharmacology are highlighted in blue

heat shock protein family A (Hsp70) member 1A Show summary »« Hide summary

Target Id	2539
Nomenclature	heat shock protein family A (Hsp70) member 1A
Previous and unofficial names	heat shock 70kD protein 1A \| Heat shock 70 kDa protein 1/2 \| Heat shock 70 kDa protein 1A/1B \| HSP70.1/HSP70.2 \| HSPA1 \| heat shock 70kDa protein 1A \| heat shock protein 1A \| heat shock protein family A member 1A \| Hspa1a \| Hspa1b \| heat shock protein family A (Hsp70) member 1B
Genes	HSPA1A (Hs), Hspa1a (Mm), Hspa1a (Rn)
Ensembl ID	ENSG00000204389 (Hs), ENSMUSG00000091971 (Mm), ENSRNOG00000045654 (Rn), ENSRNOG00000050647 (Rn)
UniProtKB AC	P0DMV8 (Hs), Q61696 (Mm), P0DMW0 (Rn)

heat shock protein family A (Hsp70) member 1B Show summary »« Hide summary

Target Id	2540
Nomenclature	heat shock protein family A (Hsp70) member 1B
Previous and unofficial names	heat shock 70kD protein 1B \| heat shock 70 kDa protein 1/2 \| heat shock 70 kDa protein 1A/1B \| HSP70A1 \| HSP72 \| heat shock 70kDa protein 1B \| heat shock protein 1B \| heat shock protein family A member 1B \| Hspa1b \| Hspa1a \| heat shock protein family A (Hsp70) member 1A
Genes	HSPA1B (Hs), Hspa1b (Mm), Hspa1b (Rn)
Ensembl ID	ENSG00000204388 (Hs), ENSMUSG00000090877 (Mm), ENSRNOG00000045654 (Rn), ENSRNOG00000050647 (Rn)
UniProtKB AC	P0DMV9 (Hs), P17879 (Mm), P0DMW1 (Rn)

heat shock protein family A (Hsp70) member 2 Show summary »« Hide summary

Target Id	2541
Nomenclature	heat shock protein family A (Hsp70) member 2
Previous and unofficial names	heat shock protein 70.2 \| heat shock protein alpha 2 \| HSP70A2 \| Hst70 \| heat shock 70kDa protein 2 \| heat shock protein 2 \| heat shock protein family A member 2
Genes	HSPA2 (Hs), Hspa2 (Mm), Hspa2 (Rn)
Ensembl ID	ENSG00000126803 (Hs), ENSMUSG00000059970 (Mm), ENSRNOG00000006472 (Rn)
UniProtKB AC	P54652 (Hs), P17156 (Mm), P14659 (Rn)

heat shock protein family A (Hsp70) member 5 Show summary »« Hide summary

Target Id

3193

Nomenclature

heat shock protein family A (Hsp70) member 5

Previous and unofficial names

BiP | glucose-regulated protein, 78kDa | GRP78 | HEL-S-89n

Genes

HSPA5 (Hs), Hspa5 (Mm), Hspa5 (Rn)

Ensembl ID

ENSG00000044574 (Hs), ENSMUSG00000026864 (Mm), ENSRNOG00000018294 (Rn)

UniProtKB AC

P11021 (Hs), P20029 (Mm), P06761 (Rn)

Endogenous ligands

cerebral dopamine neurotrophic factor (CDNF, Q49AH0) (Binding)

Comment

HSPA5 is a typical HSP70 chaperone that is involved in the folding and assembly of proteins at the endoplasmic reticulum. The protein is considered as a potential therapeutic target for viral infections [1,8-9], chemoresistant cancers and inflammation.

heat shock protein family A (Hsp70) member 6 Show summary »« Hide summary

Target Id	2542
Nomenclature	heat shock protein family A (Hsp70) member 6
Previous and unofficial names	Heat shock 70 kDa protein B \| heat shock 70kDa protein 6 (HSP70B')
Genes	HSPA6 (Hs)
Ensembl ID	ENSG00000173110 (Hs)
UniProtKB AC	P17066 (Hs)

heat shock protein family A (Hsp70) member 8 Show summary »« Hide summary

heat shock protein family A (Hsp70) member 1 like / HSPA1L Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2989
Nomenclature	heat shock protein family A (Hsp70) member 1 like
Systematic nomenclature	HSPA1L
Previous and unofficial names	heat shock 70kDa protein 1-like \| heat shock 70kD protein-like 1 \| HSP70-HOM \| hum70t
Genes	HSPA1L (Hs), Hspa1l (Mm), Hspa1l (Rn)
Ensembl ID	ENSG00000204390 (Hs), ENSMUSG00000007033 (Mm), ENSRNOG00000047966 (Rn)
UniProtKB AC	P34931 (Hs), P16627 (Mm), P55063 (Rn)

HSP90B1 (heat shock protein 90 beta family member 1) Show summary »« Hide summary More detailed page go icon to follow link

HSP90AA1 (heat shock protein 90 alpha family class A member 1) Show summary »« Hide summary More detailed page go icon to follow link

HSP90AB1 (heat shock protein 90 alpha family class B member 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2907

Nomenclature

heat shock protein 90 alpha family class B member 1

Common abbreviation

HSP90AB1

Previous and unofficial names

HSP90AB1 | HSp90AB1 | heat shock protein 90 alpha (cytosolic), class B member 1 | heat shock protein 90 alpha (cytosolic)

Genes

HSP90AB1 (Hs), Hsp90ab1 (Mm), Hsp90ab1 (Rn)

Ensembl ID

ENSG00000096384 (Hs), ENSMUSG00000023944 (Mm), ENSRNOG00000019834 (Rn)

UniProtKB AC

P08238 (Hs), P11499 (Mm), P34058 (Rn)

Inhibitors

luminespib pIC₅₀ 8.7

Sub/family-selective inhibitors

geldanamycin pIC₅₀ 6.6 [3]

TRAP1 (TNF receptor associated protein 1) Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Elfiky AA, Ibrahim IM, Amin FG, Ismail AM, Elshemey WM. (2021) COVID-19 and Cell Stress. Adv Exp Med Biol, 1318: 169-178. [PMID:33973178]

2. Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. (2014) Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases. Bioorg Med Chem Lett, 24 (1): 204-8. [PMID:24332488]

3. Gavenonis J, Jonas NE, Kritzer JA. (2014) Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. Bioorg Med Chem, 22 (15): 3989-93. [PMID:24984936]

4. Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J et al.. (2006) Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem, 49 (15): 4606-15. [PMID:16854066]

5. Kung PP, Funk L, Meng J, Collins M, Zhou JZ, Johnson MC, Ekker A, Wang J, Mehta P, Yin MJ et al.. (2008) Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg Med Chem Lett, 18 (23): 6273-8. [PMID:18929486]

6. Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A et al.. (2015) Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem, 58 (9): 3922-43. [PMID:25901531]

7. Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq K, Bosma R, Nederpelt I, Heitman LH et al.. K4DD drug target binding kinetics data. ,. DOI: 10.6019/CHEMBL3885741

8. Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I et al.. (2021) Multi-level inhibition of coronavirus replication by chemical ER stress. Nat Commun, 12 (1): 5536. [PMID:34545074]

9. Shin J, Toyoda S, Nishitani S, Fukuhara A, Kita S, Otsuki M, Shimomura I. (2021) Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19. Diabetes, 70 (12): 2745-2755. [PMID:34615619]

10. Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D et al.. (2013) Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J Med Chem, 56 (17): 6803-18. [PMID:23965125]

11. Wang J, Grishin AV, Ford HR. (2016) Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol, 196 (12): 5130-7. [PMID:27194788]

How to cite this family page

Database page citation:

Heat shock proteins. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=784.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.