ERK subfamily

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Kinases (EC 2.7.x.x)
CMGC: Containing CDK, MAPK, GSK3, CLK families
Mitogen-activated protein kinases (MAP kinases)
ERK subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

ERK1 (mitogen-activated protein kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1494

Nomenclature

mitogen-activated protein kinase 3

Common abbreviation

ERK1

Previous and unofficial names

Genes

MAPK3 (Hs), Mapk3 (Mm), Mapk3 (Rn)

Ensembl ID

ENSG00000102882 (Hs), ENSMUSG00000063065 (Mm), ENSRNOG00000053583 (Rn)

UniProtKB AC

P27361 (Hs), Q63844 (Mm), P21708 (Rn)

EC number

2.7.11.24

ERK2 (mitogen-activated protein kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1495

Nomenclature

mitogen-activated protein kinase 1

Common abbreviation

ERK2

Previous and unofficial names

Genes

MAPK1 (Hs), Mapk1 (Mm), Mapk1 (Rn)

Ensembl ID

ENSG00000100030 (Hs), ENSMUSG00000063358 (Mm), ENSRNOG00000001849 (Rn)

UniProtKB AC

P28482 (Hs), P63085 (Mm), P63086 (Rn)

EC number

2.7.11.24

Selective inhibitors

SCH772984 pIC₅₀ 9.0 [1], 8.4 [1]

ERK3 (mitogen-activated protein kinase 6) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2092

Nomenclature

mitogen-activated protein kinase 6

Common abbreviation

ERK3

Previous and unofficial names

Genes

MAPK6 (Hs), Mapk6 (Mm), Mapk6 (Rn)

Ensembl ID

ENSG00000069956 (Hs), ENSMUSG00000042688 (Mm), ENSRNOG00000009381 (Rn)

UniProtKB AC

Q16659 (Hs), Q61532 (Mm), P27704 (Rn)

EC number

2.7.11.24

ERK4 (mitogen-activated protein kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

ERK5 (mitogen-activated protein kinase 7) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2093

Nomenclature

mitogen-activated protein kinase 7

Common abbreviation

ERK5

Previous and unofficial names

big MAP kinase 1 | BMK1 | MAP kinase 7 | PRKM7 | extracellular signal-regulated kinase 5

Genes

MAPK7 (Hs), Mapk7 (Mm), Mapk7 (Rn)

Ensembl ID

ENSG00000166484 (Hs), ENSMUSG00000001034 (Mm), ENSRNOG00000047907 (Rn)

UniProtKB AC

Q13164 (Hs), Q9WVS8 (Mm), P0C865 (Rn)

EC number

2.7.11.24

Selective inhibitors

XMD8-92 pK_d 7.1 [2]

References

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How to cite this family page

Database page citation:

ERK subfamily. Accessed on 02/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=514.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.