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SLC46 family of folate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Based on the proptypical member of this family, PCFT, this family includes proton-driven transporters with 11 TM segments. SLC46A1 has been described to act as an intestinal proton-coupled high-affinity folic acid transporter [2], with lower affinity for heme. Folic acid accumulation is independent of Na+ or K+ ion concentrations, but driven by extracellular protons with an as yet undefined stoichiometry.

Transporters

1213
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PCFT (Proton-coupled folate transporter / SLC46A1) C Show summary »


Target Id 1213
Nomenclature Proton-coupled folate transporter
Systematic nomenclature SLC46A1
Common abbreviation PCFT
Previous and unofficial names HCP1 | heme carrier protein 1 | solute carrier family 46, member 1 | PCFT/HCP1 | solute carrier family 46 (folate transporter), member 1 | solute carrier family 46
Genes SLC46A1 (Hs), Slc46a1 (Mm), Slc46a1 (Rn)
Ensembl ID ENSG00000076351 (Hs), ENSMUSG00000020829 (Mm), ENSRNOG00000010291 (Rn)
UniProtKB AC Q96NT5 (Hs), Q6PEM8 (Mm), Q5EBA8 (Rn)
Bioparadigms SLC Tables SLC46A1 (Hs)
Substrates folic acid (1.3µM) > heme (>100 µM)  [1]
Endogenous substrates
N5-methyltetrafolate [2]
Substrates
methotrexate [2]
N-formyltetrahydrofolate
pemetrexed
Labelled ligands
[3H]folic acid
[3H]methotrexate
[3H]pemetrexed (Binding)
[3H]N5-methylfolate (Binding)
[3H]folinic acid (Binding)
Comment Loss-of-function mutations in PCFT (SLC46A1) are the molecular basis for hereditary folate maladsorption [3].

TSCOT (Thymic stromal co-transporter / SLC46A2) Show summary »

SLC46A3 Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC46 family of folate transporters. Accessed on 20/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=235.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.