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Neutral amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Certain members of neutral amino acid transport family are expressed upon the apical surface of epithelial cells and are important for the absorption of amino acids from the duodenum, jejunum and ileum and their reabsorption within the proximal tubule of the nephron (i.e. B0AT1 (SLC6A19), SLC6A18, SLC6A20). Others may function as transporters for neurotransmitters or their precursors (i.e. B0AT2, SLC6A17) [5]. B0AT1 has been proposed as a drug target to treat phenylketonuria [1].

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

B0AT1 / SLC6A19 C Show summary »

B0AT2 / SLC6A15 C Show summary »

B0AT3 / SLC6A18 C Show summary »

NTT5 / SLC6A16 C Show summary »

NTT4 / SLC6A17 C Show summary »

SIT1 / SLC6A20 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.