SLC3 family | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC3 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC3 family members are single TM proteins with extensive glycosylation of the exterior C-terminus, which heterodimerize with SLC7 family members in the endoplasmic reticulum and assist in the plasma membrane localization of the transporter.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

rBAT / SLC3A1 Show summary »« Hide summary

Target Id	889
Nomenclature	rBAT
Systematic nomenclature	SLC3A1
Previous and unofficial names	ATR1 \| Cystine, dibasic, and neutral amino acid transporter \| CSNU1 \| D2H \| NBAT \| b(0,+)-type amino acid transport protein \| D2 \| NAA-Tr \| neutral and basic amino acid transport protein rBAT \| solute carrier family 3, member 1 \| NTAA \| solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 \| solute carrier family 3 (amino acid transporter heavy chain), member 1 \| solute carrier family 3
Genes	SLC3A1 (Hs), Slc3a1 (Mm), Slc3a1 (Rn)
Ensembl ID	ENSG00000138079 (Hs), ENSMUSG00000024131 (Mm), ENSRNOG00000007006 (Rn)
UniProtKB AC	Q07837 (Hs), Q91WV7 (Mm), Q64319 (Rn)
Bioparadigms SLC Tables	SLC3A1 (Hs)
RESOLUTE	SLC3A1 (Hs)

4F2hc / SLC3A2 Show summary »« Hide summary

Target Id

890

Nomenclature

4F2hc

Systematic nomenclature

SLC3A2

Previous and unofficial names

Genes

SLC3A2 (Hs), Slc3a2 (Mm), Slc3a2 (Rn)

Ensembl ID

ENSG00000168003 (Hs), ENSMUSG00000010095 (Mm), ENSRNOG00000018487 (Rn)

UniProtKB AC

P08195 (Hs), P10852 (Mm), Q794F9 (Rn)

Bioparadigms SLC Tables

SLC3A2 (Hs)

RESOLUTE

SLC3A2 (Hs)

Antibodies

IGN523 (Binding) pK_d 8.9 [1]

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.