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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
These transporters are thought to translocate the aminophospholipids phosphatidylserine and phosphatidylethanolamine from one side of the phospholipid bilayer to the other to generate asymmetric membranes. They are also proposed to be involved in the generation of vesicles from intracellular and cell-surface membranes.
ATP8A1 (Phospholipid-transporting ATPase IA) Show summary » |
ATP8A2 (Phospholipid-transporting ATPase IB) Show summary » |
ATP8B1 (Phospholipid-transporting ATPase IC) Show summary » |
ATP8B2 (Phospholipid-transporting ATPase ID) Show summary » |
ATP8B3 (Phospholipid-transporting ATPase IK) Show summary » |
ATP8B4 (Probable phospholipid-transporting ATPase IM) Show summary » |
ATP9A (Probable phospholipid-transporting ATPase IIA) Show summary » |
ATP9B (Probable phospholipid-transporting ATPase IIB) Show summary » |
ATP10A (Probable phospholipid-transporting ATPase VA) Show summary » |
ATP10B (Probable phospholipid-transporting ATPase VB) Show summary » |
ATP10D (Probable phospholipid-transporting ATPase VD) Show summary » |
ATP11A (Probable phospholipid-transporting ATPase IH) Show summary » |
ATP11B (Probable phospholipid-transporting ATPase IF) Show summary » |
ATP11C (Phospholipid-transporting ATPase IG) Show summary » |
transmembrane protein 30A Show summary » |
Database page citation:
P4 P-type ATPases: Phospholipid-transporting ATPases. Accessed on 03/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=162.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.
Loss-of-function mutations in ATP8B1 are associated with type I familial intrahepatic cholestasis.