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SIGLECs (conserved)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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This subfamily of 4 SIGLECs share conserved sequence homology. SIGLEC15 from this group has been implicated in myeloid cell-mediated modulation in cancer making it a novel therapeutic target to enhance antitumour immunity (cancer immunotherapy) [1,3-4,6-7].

Targets

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Targets of relevance to immunopharmacology are highlighted in blue

SIGLEC2 (CD22) Show summary » More detailed page go icon to follow link

SIGLEC15 (sialic acid binding Ig like lectin 15) Show summary »

References

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How to cite this family page

Database page citation:

SIGLECs (conserved). Accessed on 02/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1094.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.