E2 ubiquitin-conjugating enzymes

From August 18th 2026, GtoPdb will require users to register to use the website. Please see our blog post for more information.

Home
Targets
Enzymes
E2 ubiquitin-conjugating enzymes

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

ubiquitin conjugating enzyme E2 D1 Show summary »« Hide summary

Target Id

3228

Nomenclature

ubiquitin conjugating enzyme E2 D1

Genes

UBE2D1 (Hs), Ube2d1 (Mm), Ube2d1 (Rn)

Ensembl ID

ENSG00000072401 (Hs), ENSMUSG00000019927 (Mm), ENSRNOG00000000611 (Rn)

UniProtKB AC

P51668 (Hs), P61080 (Mm), D3ZDK2 (Rn)

EC number

2.3.2.23

2.3.2.24

Ligands

EN450 (Binding) (degrader) [1]

Comment

One of four human UBE2D genes (UBE2D1-4), that encode E2 ubiquitin-conjugating enzymes, that are involved in the second step in the ubiquitination process that ultimately leads to proteosome-mediated protein degradation.

ubiquitin conjugating enzyme E2 D2 Show summary »« Hide summary

Target Id

3229

Nomenclature

ubiquitin conjugating enzyme E2 D2

Genes

UBE2D2 (Hs), Ube2d2a (Mm), Ube2d2 (Rn)

Ensembl ID

ENSG00000131508 (Hs), ENSMUSG00000091896 (Mm), ENSRNOG00000069286 (Rn)

UniProtKB AC

P62837 (Hs), P51669 (Mm), P62838 (Mm), P62839 (Rn)

EC number

2.3.2.23

2.3.2.24

Comment

References

Show »« Hide

How to cite this family page

Database page citation:

E2 ubiquitin-conjugating enzymes. Accessed on 15/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1078.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.