Pyrimidine salvage

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Pyrimidine salvage

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CDA scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for uridine monophosphate (UMP) synthesis.

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

cytidine deaminase Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3133

Nomenclature

cytidine deaminase

Previous and unofficial names

cytidine aminohydrolase | cytosine nucleoside deaminase

Genes

CDA (Hs)

Ensembl ID

ENSG00000158825 (Hs)

UniProtKB AC

P32320 (Hs)

EC number

3.5.4.5

cytidine + H⁺ + H₂O = NH₄⁺ + uridine

Inhibitors

cedazuridine pIC₅₀ 6.4 [1]

References

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How to cite this family page

Database page citation:

Pyrimidine salvage. Accessed on 01/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1040.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.