Acyl-CoA synthetases

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Acyl-CoA synthetases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ACSS2 is a monomeric cytosolic enzyme that catalyses the formation of acetyl-CoA from acetate, CoA, and ATP. It plays a role in the biosynthesis of cholesterol, glucose, and fatty acids. ACSS2 is also a drug target for cancer and neurodegenerative diseases [1].

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

acyl-CoA synthetase short chain family member 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3128
Nomenclature	acyl-CoA synthetase short chain family member 2
Genes	ACSS2 (Hs)
Ensembl ID	ENSG00000131069 (Hs)
UniProtKB AC	Q9NR19 (Hs)

References

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How to cite this family page

Database page citation:

Acyl-CoA synthetases. Accessed on 15/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1036.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.