SLC56 Sideroflexins | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC56 Sideroflexins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

sideroflexin 1 / SLC56A1 C Show summary »« Hide summary

Target Id	3028
Nomenclature	sideroflexin 1
Systematic nomenclature	SLC56A1
Previous and unofficial names	FLJ12876
Genes	SFXN1 (Hs), Sfxn1 (Mm), Sfxn1 (Rn)
Ensembl ID	ENSG00000164466 (Hs), ENSMUSG00000021474 (Mm), ENSRNOG00000018279 (Rn)
UniProtKB AC	Q9H9B4 (Hs), Q99JR1 (Mm)
RESOLUTE	SFXN1 (Hs)
Comment	Sideroflexin 1 (SFXN1/SLC56A1) was probably falsely identified as a tricarboxylate carrier in the 1993 article by Azzi et al. [1], as discussed several years later in [2]. SFXN1 likely transports pyridoxin or another heme precursor or the 5'-aminolevulinate synthase 2 (ALAS2; P22557) cofactor [2,4]. SFXN1 has recently been suggested to be a mitochondrial serine transporter [3]. It is mainly expressed in adult kidney and liver (mouse) [2].

sideroflexin 2 / SLC56A2 C Show summary »« Hide summary

Target Id	3029
Nomenclature	sideroflexin 2
Systematic nomenclature	SLC56A2
Genes	SFXN2 (Hs), Sfxn2 (Mm), Sfxn2 (Rn)
Ensembl ID	ENSG00000156398 (Hs), ENSMUSG00000025036 (Mm), ENSRNOG00000066618 (Rn)
UniProtKB AC	Q96NB2 (Hs), Q925N2 (Mm)
RESOLUTE	SFXN2 (Hs)
Comment	In mice sideroflexin 2 expression is mainly detected in adult kidney and liver [2]. In human tissues it is detected at highest levels in kidney, liver and pancreas [4].

sideroflexin 3 / SLC56A3 C Show summary »« Hide summary

Target Id	3030
Nomenclature	sideroflexin 3
Systematic nomenclature	SLC56A3
Previous and unofficial names	SFX3
Genes	SFXN3 (Hs), Sfxn3 (Mm), Sfxn3 (Rn)
Ensembl ID	ENSG00000107819 (Hs), ENSMUSG00000025212 (Mm), ENSRNOG00000015442 (Rn)
UniProtKB AC	Q9BWM7 (Hs), Q91V61 (Mm), Q9JHY2 (Rn)
RESOLUTE	SFXN3 (Hs)
Comment	Sideroflexin 3 is ubiquitously expressed in mouse tissues [2].

sideroflexin 4 / SLC56A4 C Show summary »« Hide summary

Target Id	3031
Nomenclature	sideroflexin 4
Systematic nomenclature	SLC56A4
Comment	Sideroflexin 4 is expressed in mouse kidney, brain and heart [2]. The SFXN4a isoform is most highly expressed in human kidney and pancreas, and the SFXN4b isoform is barely detectable in brain [5].

sideroflexin 5 / SLC56A5 C Show summary »« Hide summary

Target Id	3032
Nomenclature	sideroflexin 5
Systematic nomenclature	SLC56A5
Previous and unofficial names	BBG-TCC
Genes	SFXN5 (Hs), Sfxn5 (Mm), Sfxn5 (Rn)
Ensembl ID	ENSG00000144040 (Hs), ENSMUSG00000033720 (Mm), ENSRNOG00000037871 (Rn)
UniProtKB AC	Q8TD22 (Hs), Q925N0 (Mm), Q8CFD0 (Rn)
RESOLUTE	SFXN5 (Hs)
Comment	Sideroflexin 5 is expressed in mouse brain and liver [2].

Comments

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References

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1. Azzi A, Glerum M, Koller R, Mertens W, Spycher S. (1993) The mitochondrial tricarboxylate carrier. J Bioenerg Biomembr, 25 (5): 515-24. [PMID:8132491]

2. Fleming MD, Campagna DR, Haslett JN, Trenor 3rd CC, Andrews NC. (2001) A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev, 15 (6): 652-7. [PMID:11274051]

3. Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR et al.. (2018) SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science, 362 (6416). [PMID:30442778]

4. Ye X, Xu J, Cheng C, Yin G, Zeng L, Ji C, Gu S, Xie Y, Mao Y. (2003) Isolation and characterization of a novel human putative anemia-related gene homologous to mouse sideroflexin. Biochem Genet, 41 (3-4): 119-25. [PMID:12670026]

5. Zheng H, Ji C, Zou X, Wu M, Jin Z, Yin G, Li J, Feng C, Cheng H, Gu S et al.. (2003) Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia. DNA Seq, 14 (5): 369-73. [PMID:14756423]

How to cite this family page

Database page citation:

SLC56 Sideroflexins. Accessed on 02/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1008.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.