SLC53 Phosphate carriers | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC53 Phosphate carriers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

xenotropic and polytropic retrovirus receptor 1 / SLC53A1 C Show summary »« Hide summary

Target Id

3021

Nomenclature

xenotropic and polytropic retrovirus receptor 1

Systematic nomenclature

SLC53A1

Previous and unofficial names

SYG1 | XR

Genes

XPR1 (Hs), Xpr1 (Mm), Xpr1 (Rn)

Ensembl ID

ENSG00000143324 (Hs), ENSMUSG00000026469 (Mm), ENSRNOG00000000042 (Rn)

UniProtKB AC

Q9UBH6 (Hs), Q9Z0U0 (Mm)

RESOLUTE

XPR1 (Hs)

Substrates

Phosphate [3]

Comment

XPR1/SLC53A1 is a phosphate carrier which appears to play a role in bone and tooth mineralization. Cryo-EM structures and electrophysiology experiments have revealed that inorganic phosphate export via XPR1 is mediated by an inositol pyrophosphate-gated channel-like structure [5,7]. XPR1/SLC53A1 is ubiquitously expressed [2,6]. The pathological consequences of defective SLC53A1 expression in the brain [4] and kidney [1] have been reported.

References

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1. Ansermet C, Moor MB, Centeno G, Auberson M, Hu DZ, Baron R, Nikolaeva S, Haenzi B, Katanaeva N, Gautschi I et al.. (2017) Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron. J Am Soc Nephrol, 28 (4): 1073-1078. [PMID:27799484]

2. Battini JL, Rasko JE, Miller AD. (1999) A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction. Proc Natl Acad Sci USA, 96 (4): 1385-90. [PMID:9990033]

3. Giovannini D, Touhami J, Charnet P, Sitbon M, Battini JL. (2013) Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. Cell Rep, 3 (6): 1866-73. [PMID:23791524]

4. Legati A, Giovannini D, Nicolas G, López-Sánchez U, Quintáns B, Oliveira JR, Sears RL, Ramos EM, Spiteri E, Sobrido MJ et al.. (2015) Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nat Genet, 47 (6): 579-81. [PMID:25938945]

5. Lu Y, Yue CX, Zhang L, Yao D, Xia Y, Zhang Q, Zhang X, Li S, Shen Y, Cao M et al.. (2024) Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1. Science, 386 (6723): eadp3252. [PMID:39325866]

6. Tailor CS, Nouri A, Lee CG, Kozak C, Kabat D. (1999) Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. Proc Natl Acad Sci USA, 96 (3): 927-32. [PMID:9927670]

7. Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D. (2024) Human XPR1 structures reveal phosphate export mechanism. Nature, 633 (8031): 960-967. [PMID:39169184]

How to cite this family page

Database page citation:

SLC53 Phosphate carriers. Accessed on 05/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1005.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC53 Phosphate carriers C

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

Further reading

References

How to cite this family page