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ChEMBL ligand: CHEMBL1258913 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 6.48 | pIC50 | 332 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of CDC7 | B | 5.71 | pIC50 | 1970 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of CDK2/cyclinA | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 | B | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of MET | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
High affinity immunoglobulin gamma Fc receptor I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5349] [UniProtKB: P12314] | ||||||||
ChEMBL | Inhibition of IGFR1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of IKKi | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of IR | B | 5.15 | pIC50 | 7012 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MAPKAPK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of p38alpha | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Inhibition of TRKA | B | 6.74 | pIC50 | 181 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of PKCbeta | B | 5.92 | pIC50 | 1212 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 6.12 | pIC50 | 762 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-20 [PMID:20817473] |
ChEMBL | Inhibition of AurA | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of aurora B | B | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
GtoPdb | - | - | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-20 [PMID:20817473] |
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9] | ||||||||
ChEMBL | Inhibition of aurora C | B | 7.21 | pIC50 | 62 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
GtoPdb | - | - | 7.21 | pIC50 | 62 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-20 [PMID:20817473] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 | B | 5.79 | pIC50 | 1634 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
ChEMBL | Inhibition of MST4 | B | 6.39 | pIC50 | 412 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
ChEMBL | Inhibition of NIM1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 | B | 6.34 | pIC50 | 455 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of PLK1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of KIT | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of ABL | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] | ||||||||
ChEMBL | Inhibition of BRK | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 5.76 | pIC50 | 1721 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 5.43 | pIC50 | 3710 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
ChEMBL | Inhibition of LYN | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
ChEMBL | Inhibition of RET | B | 6.95 | pIC50 | 113 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of VEGFR2 | B | 6.79 | pIC50 | 162 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of VEGFR3 | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-7120 [PMID:20817473] |
serine/threonine kinase 4 in Human [GtoPdb: 2225] [UniProtKB: Q13043] | ||||||||
GtoPdb | - | - | 6.39 | pIC50 | 412 | nM | IC50 | Bioorg Med Chem (2010) 18: 7113-20 [PMID:20817473] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]