compound 25 [PMID: 17935989] [Ligand Id: 8122] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL248757 |
|---|
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478] | ||||||||
| ChEMBL | Inhibition of AMPK | B | 5.81 | pKi | 1539 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012] | ||||||||
| ChEMBL | Inhibition of CAMK1 | B | 5.78 | pKi | >1677 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
| ChEMBL | Inhibition of CAMK4 | B | 5.07 | pKi | >8571 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | Inhibition of CK1alpha1 | B | 5.16 | pKi | >6916 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| ChEMBL | Inhibition of CK1delta | B | 5.11 | pKi | >7826 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368] | ||||||||
| ChEMBL | Inhibition of CK1gamma 2 | B | 5.14 | pKi | >7166 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Inhibition of CK2 | B | 5.23 | pKi | >5833 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Inhibition of CDC2 | B | 5.05 | pKi | >8913 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of CDK2 | B | 5.51 | pKi | 3088 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| ChEMBL | Inhibition of CDK5 | B | 5.03 | pKi | >9275 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534] | ||||||||
| ChEMBL | Inhibition of CDK6 | B | 5.81 | pKi | >1549 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
| ChEMBL | Inhibition of CDK7 | B | 5.82 | pKi | >1525 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| ChEMBL | Inhibition of CDK9 | B | 5.78 | pKi | >1644 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
| ChEMBL | Inhibition of ZIPk | B | 5.86 | pKi | >1391 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
| ChEMBL | Inhibition of CLK2 | B | 5.06 | pKi | >8753 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
| ChEMBL | Inhibition of CLK4 | B | 5.05 | pKi | >8951 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
| ChEMBL | Inhibition of DYRK1A | B | 5.47 | pKi | 3401 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] | ||||||||
| ChEMBL | Inhibition of DYRK3 | B | 5.24 | pKi | >5804 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
| ChEMBL | Inhibition of EPHA2 | B | 5.1 | pKi | >8000 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of EGFR | B | 5.74 | pKi | >1803 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Inhibition of FGFR | B | 5.32 | pKi | >4737 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Inhibition of FGFR3 | B | 5.73 | pKi | >1863 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
| ChEMBL | Inhibition of GSK3 alpha | B | 6.04 | pKi | 911 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of GSK3 beta | B | 5.15 | pKi | >7059 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] | ||||||||
| ChEMBL | Inhibition of HIPK2 | B | 5.12 | pKi | >7664 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ChEMBL | Inhibition of HIPK2 | B | 5.48 | pKi | >3338 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
| ChEMBL | Inhibition of IKK alpha | B | 5.43 | pKi | >3750 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
| ChEMBL | Inhibition of IKK beta | B | 5.63 | pKi | >2338 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Inhibition of IGF1R | B | 6 | pKi | >991 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Inhibition of INSR | B | 5.28 | pKi | >5238 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
| ChEMBL | Inhibition of IRAK1 | B | 5.52 | pKi | 3011 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
| ChEMBL | Inhibition of IRAK4 | B | 5 | pKi | >9921 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
| ChEMBL | Inhibition of LIMK1 | B | 5.02 | pKi | >9546 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
| ChEMBL | Inhibition of MK2 | B | 5.41 | pKi | 3886 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] | ||||||||
| ChEMBL | Inhibition of MK3 | B | 5.03 | pKi | >9234 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
| ChEMBL | Inhibition of PRAK | B | 5.82 | pKi | >1525 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of ERK2 | B | 5.06 | pKi | >8750 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
| ChEMBL | Inhibition of P38delta | B | 5.17 | pKi | 6812 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
| ChEMBL | Inhibition of P38 gamma | B | 5.12 | pKi | >7500 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
| ChEMBL | Inhibition of MNK2 | B | 5.03 | pKi | >9350 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
| ChEMBL | Inhibition of EMK | B | 5.37 | pKi | 4266 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8] | ||||||||
| ChEMBL | Inhibition of MINK1 | B | 5.07 | pKi | >8493 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
| ChEMBL | Inhibition of MLK1 | B | 5.78 | pKi | >1667 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851] | ||||||||
| ChEMBL | Inhibition of MAP4K2 | B | 5.19 | pKi | >6516 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
| ChEMBL | Inhibition of ZAK | B | 5.07 | pKi | >8573 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] | ||||||||
| GtoPdb | - | - | 5.78 | pKi | 1650 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| ChEMBL | Inhibition of MUSK | B | 5.78 | pKi | >1650 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Inhibition of TRKA | B | 5.61 | pKi | >2481 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Inhibition of TRKB | B | 5.34 | pKi | >4536 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285] | ||||||||
| ChEMBL | Inhibition of ARK5 | B | 5.82 | pKi | >1503 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| PDZ binding kinase/PDZ-binding kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4896] [GtoPdb: 2140] [UniProtKB: Q96KB5] | ||||||||
| ChEMBL | Inhibition of PBK | B | 5.28 | pKi | 5195 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Inhibition of PKC delta | B | 5.05 | pKi | >8889 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
| ChEMBL | Inhibition of PKC gamma | B | 5.06 | pKi | >8750 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| ChEMBL | Inhibition of PRKCN | B | 5.04 | pKi | >9217 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
| ChEMBL | Inhibition of PKC zeta | B | 5.08 | pKi | >8333 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513] | ||||||||
| ChEMBL | Inhibition of PKN2 | B | 5.09 | pKi | >8195 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
| ChEMBL | Inhibition of PDK1 | B | 5.46 | pKi | 3482 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
| ChEMBL | Inhibition of ERBB2 | B | 5.84 | pKi | >1438 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
| ChEMBL | Inhibition of ERBB4 | B | 5.43 | pKi | >3750 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
| ChEMBL | Inhibition of ROCK1 | B | 5.04 | pKi | >9105 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
| ChEMBL | Inhibition of ROCK2 | B | 5.12 | pKi | >7500 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
| ChEMBL | Inhibition of P70S6K | B | 5.18 | pKi | >6668 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
| ChEMBL | Inhibition of RSK2 | B | 5.13 | pKi | >7368 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
| ChEMBL | Inhibition of MSK2 | B | 6.02 | pKi | 949 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
| ChEMBL | Inhibition of MSK1 | B | 5.72 | pKi | >1892 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| serine/threonine kinase 31/Serine/threonine-protein kinase 31 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6151] [GtoPdb: 2220] [UniProtKB: Q9BXU1] | ||||||||
| ChEMBL | Inhibition of STK31 | B | 5.84 | pKi | >1442 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 5.85 | pKi | >1422 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3] | ||||||||
| ChEMBL | Inhibition of STK33 | B | 5.79 | pKi | >1638 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of AKT1 | B | 5.43 | pKi | 3698 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Inhibition of AKT2 | B | 5.32 | pKi | 4800 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Inhibition of AKT3 | B | 5.15 | pKi | 7157 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
| ChEMBL | Inhibition of Chk1 | B | 8.4 | pKi | 4 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ChEMBL | Inhibition of Chk1 | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
| ChEMBL | Inhibition of CHK2 | B | 5.25 | pKi | >5578 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
| ChEMBL | Inhibition of CTAK1 | B | 5.18 | pKi | >6667 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Inhibition of PKD2 | B | 5.05 | pKi | >8980 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568] | ||||||||
| ChEMBL | Inhibition of DCAMKL2 | B | 5.02 | pKi | >9570 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] | ||||||||
| ChEMBL | Inhibition of CDC42BPA | B | 5.02 | pKi | >9524 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66] | ||||||||
| ChEMBL | Inhibition of NEK11 | B | 5.81 | pKi | >1549 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 5.81 | pKi | >1549 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
| ChEMBL | Inhibition of NEK2 | B | 5.03 | pKi | >9242 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956] | ||||||||
| ChEMBL | Inhibition of NEK3 | B | 5.78 | pKi | >1667 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 5.78 | pKi | >1667 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957] | ||||||||
| ChEMBL | Inhibition of NEK4 | B | 5.17 | pKi | >6711 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8] | ||||||||
| ChEMBL | Inhibition of NLK | B | 5.79 | pKi | >1611 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 5.79 | pIC50 | 1611 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
| ChEMBL | Inhibition of PAK1 | B | 5.01 | pKi | >9727 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
| ChEMBL | Inhibition of PAK4 | B | 5.26 | pKi | >5454 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Inhibition of PIM1 | B | 5.04 | pKi | 9182 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
| ChEMBL | Inhibition of PIM2 | B | 5.85 | pKi | >1424 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Inhibition of PLK1 | B | 5.18 | pKi | 6560 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
| ChEMBL | Inhibition of PLK3 | B | 5.96 | pKi | 1085 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817] | ||||||||
| ChEMBL | Inhibition of PRKX | B | 5.83 | pKi | >1488 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141] | ||||||||
| ChEMBL | Inhibition of SGK | B | 5.09 | pKi | 8176 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4] | ||||||||
| ChEMBL | Inhibition of SRPK1 | B | 5.64 | pKi | 2307 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1] | ||||||||
| GtoPdb | - | - | 5.76 | pKi | >1736 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| ChEMBL | Inhibition of MSSK1 | B | 5.76 | pKi | >1736 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
| ChEMBL | Inhibition of TAOK2 | B | 5.03 | pKi | >9334 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
| ChEMBL | Inhibition of TBK1 | B | 5.82 | pKi | >1525 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| WNK lysine deficient protein kinase 2/Serine/threonine-protein kinase WNK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5639] [GtoPdb: 2281] [UniProtKB: Q9Y3S1] | ||||||||
| ChEMBL | Inhibition of WNK2 | B | 5.82 | pKi | >1518 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 5.82 | pKi | >1518 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of c-kit | B | 5.95 | pKi | 1119 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| mitogen-activated protein kinase kinase kinase 7/TAK1/TAB1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038499] [GtoPdb: 2082] [UniProtKB: O43318, Q15750] | ||||||||
| ChEMBL | Inhibition of TAK1-TAB1 | B | 5.79 | pKi | >1606 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7] | ||||||||
| ChEMBL | Inhibition of TSSK1 | B | 5.8 | pKi | >1596 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| testis specific serine kinase 2/Testis-specific serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6014] [GtoPdb: 2258] [UniProtKB: Q96PF2] | ||||||||
| ChEMBL | Inhibition of TSSK2 | B | 5.82 | pKi | >1526 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Inhibition of ABL | B | 6.15 | pKi | >706 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
| ChEMBL | Inhibition of BLK | B | 5.84 | pKi | >1453 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | Inhibition of FYN | B | 6.09 | pKi | >809 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
| ChEMBL | Inhibition of ITK | B | 5.82 | pKi | >1525 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Inhibition of JAK2 | B | 5.84 | pKi | >1453 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Inhibition of JAK3 | B | 5.76 | pKi | >1722 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Inhibition of LCK | B | 5.57 | pKi | >2701 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Inhibition of LYN | B | 5.78 | pKi | >1667 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of FLT3 | B | 5.61 | pKi | >2481 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of SRC | B | 5.71 | pKi | >1936 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Inhibition of TYK2 | B | 5.71 | pKi | >1936 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | Inhibition of FLT1 | B | 6.36 | pKi | >440 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| GtoPdb | - | - | 6.36 | pKi | 440 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-601 [PMID:17935989] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of KDR | B | 5.05 | pKi | >8876 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
| fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
| ChEMBL | Inhibition of FLT4 | B | 5.16 | pKi | 6846 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6593-6601 [PMID:17935989] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
