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ChEMBL ligand: CHEMBL39317 (L-694247) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
GtoPdb | - | - | 9.3 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 682-8 [PMID:9205951] |
ChEMBL | Displacement of [3H]8-OH-DPAT from pig cortex 5-hydroxytryptamine 1A receptor | B | 8.5 | pIC50 | 3.16 | nM | IC50 | J Med Chem (1993) 36: 1529-1538 [PMID:8496922] |
Serotonin 1d (5-HT1d) receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105] [UniProtKB: P79400] | ||||||||
ChEMBL | Binding activity against 5-hydroxytryptamine 1D receptor from pig caudate membrane using [3H]5-HT as radioligand | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1995) 38: 1799-1810 [PMID:7752204] |
ChEMBL | Displacement of radioligand [3H]5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membrane | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1993) 36: 1529-1538 [PMID:8496922] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Displacement of [3H]mesulergine from pig cortex 5-hydroxytryptamine 1C receptor | B | 6.5 | pIC50 | 316.23 | nM | IC50 | J Med Chem (1993) 36: 1529-1538 [PMID:8496922] |
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16] | ||||||||
ChEMBL | Displacement of [3H]-Q-ICS 205-930 from rat cortex homogenate 5-hydroxytryptamine 3 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1993) 36: 1529-1538 [PMID:8496922] |
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
GtoPdb | - | - | 9.2 | pKi | 0.63 | nM | Ki | Eur J Pharmacol (1999) 380: 171-81 [PMID:10513577] |
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | Mol Pharmacol (1998) 54: 1088-96 [PMID:9855638] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]