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1820
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2823,
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2829
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139
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219
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407
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193
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406
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70
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676
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193
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878
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367
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980
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367
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79009
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2543
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2830
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2666
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2830
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2972
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193
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140
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220
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408
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605
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677
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880
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351
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879
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364
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981
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372
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1763
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45309
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1793
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45305
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1821
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45309
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2514
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2822,
2823
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2829
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2822,
2823
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228
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253,
254
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366
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349,
355,
364,
365
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373
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14867
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28133,
45305
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2549
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2603
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2651
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72
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149
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230
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131,
146
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297
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231
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206,
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245,
24739
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370
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193
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152
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233
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688
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193
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160
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242
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{
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72
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193
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245
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2828
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139
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160
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388
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182,
195
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204
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224
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245
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735
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193
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1047
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193,
24903
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2988
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193
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506
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202
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629
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202
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202
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513
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193
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2996
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193
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515
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182
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{
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514
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190,
204
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182,
190
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182
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190,
204
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516
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193
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193
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24813
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},
{
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2997
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193
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612
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203
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221
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781
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262
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773
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259,
262,
289,
326,
327
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776
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331
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289
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809
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282
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807
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324
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351
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910
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349
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1011
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388
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1010
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1640
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413,
482
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480
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1165
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482
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1252
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1316
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413,
482
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"dataPointInteractionIds": [
1085
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482,
483,
484
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},
{
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1086
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481
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},
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"dataPointInteractionIds": [
1166
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481,
482
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},
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1167
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507
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},
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"dataPointInteractionIds": [
1253
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481,
482,
484
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1254
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481
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},
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"dataPointInteractionIds": [
1317
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482,
484
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},
{
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1376
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"refIds": [
484,
614,
37191
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},
{
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"dataPointInteractionIds": [
1095
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"refIds": [
413,
482
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},
{
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1096
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480
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},
{
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1174
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413,
482
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},
{
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1261
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413,
482
]
},
{
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"dataPointInteractionIds": [
1324
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"refIds": [
413,
482
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},
{
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"affinity": "5.0",
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1378
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"refIds": [
614,
37191,
41887
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},
{
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"affinity": "9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1110
],
"refIds": [
491
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},
{
"targetId": 15,
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"action": "Antagonist",
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"affinity": "10.4",
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"dataPointInteractionIds": [
1270
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"refIds": [
586
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},
{
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"affinity": "8.5 - 9.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1115
],
"refIds": [
408,
483,
487,
491,
494,
498
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},
{
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"dataPointInteractionIds": [
1116
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"refIds": [
481,
486,
489
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},
{
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"affinity": "7.8 - 9.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1191
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"refIds": [
408,
487,
494,
41877
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},
{
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1192
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486,
507
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},
{
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"dataPointInteractionIds": [
1275
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408,
487,
494,
41877
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},
{
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1276
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"refIds": [
481,
486
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},
{
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86711
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408,
487,
494,
41877
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{
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"dataPointInteractionIds": [
1339
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"refIds": [
486
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},
{
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1389
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494,
41877,
41888
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1388
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486
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},
{
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"affinity": "4.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
86709
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"refIds": [
38215
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},
{
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"affinity": "8.9 - 9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1117
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"refIds": [
494,
28681,
28683
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},
{
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"affinity": "7.2 - 7.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1193
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"refIds": [
494,
28681,
28683
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},
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1278
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494,
28681,
28683
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1341
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494,
28681,
28683
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},
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1390
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494,
28681,
28683
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},
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"dataPointInteractionIds": [
1121
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"refIds": [
494,
24507
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},
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"dataPointInteractionIds": [
1204
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"refIds": [
494,
24507
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
1282
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"refIds": [
494,
586,
24507
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"dataPointInteractionIds": [
1345
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494
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
1394
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"refIds": [
494
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},
{
"targetId": 13,
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"dataPointInteractionIds": [
1126
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487,
489,
492,
18670,
28675,
28677
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1125
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486,
489
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},
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"dataPointInteractionIds": [
1211
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"refIds": [
487,
489,
492,
507,
551,
18670,
28675,
28677
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{
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1212
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"refIds": [
404,
486,
507
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},
{
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1287
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489,
492,
18670,
28675,
28677
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1286
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486
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},
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1349
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492,
18670,
28675,
28677
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86714
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38215
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},
{
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1348
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486
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1398
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492,
28675,
28677
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1397
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486
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{
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89266
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44926
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
1127
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487
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},
{
"targetId": 14,
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1213
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1350
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1128
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41877
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1214
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24062
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1289
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24062
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1194
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1195
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1196
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24341
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86718
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28631
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1237
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553,
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1236
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1203
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28681
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14072
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18512
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1495
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14117
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18512,
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1545
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717,
722,
18516,
18542
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{
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14295
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18560
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1605
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714,
18510
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45303
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1608
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871,
883,
28114,
45303
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45303
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1658
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871,
45303
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90350
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45303
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{
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1696
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871,
28114,
45303
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1694
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888
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},
{
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"dataPointInteractionIds": [
90388,
90387,
90386
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945,
45309,
45309
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90385
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45309
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},
{
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"dataPointInteractionIds": [
1746
],
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944,
945,
45309
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},
{
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"dataPointInteractionIds": [
90433,
90434
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"refIds": [
45309,
45309
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},
{
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"affinity": "7.6",
"affinityParameter": "pIC50",
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90432
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"refIds": [
45309
]
},
{
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"affinity": "3.6 - 5.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84157
],
"refIds": [
945,
45309
]
},
{
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"affinity": "7.6",
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90473
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"refIds": [
45309
]
},
{
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"affinity": "6.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
90472
],
"refIds": [
45309
]
},
{
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"affinity": "4.9 - 5.8",
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"dataPointInteractionIds": [
84158
],
"refIds": [
945,
45309
]
},
{
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"affinity": "7.6",
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"dataPointInteractionIds": [
90509
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"refIds": [
14875
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},
{
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"dataPointInteractionIds": [
84160
],
"refIds": [
986,
1051,
14875
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},
{
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"affinity": "7.9",
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"dataPointInteractionIds": [
90543
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14875
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},
{
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"dataPointInteractionIds": [
1862
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"refIds": [
986,
1013,
1051,
14875
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},
{
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90569
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14875
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},
{
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"dataPointInteractionIds": [
84162
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1051,
14875
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},
{
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"dataPointInteractionIds": [
90303
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14845,
41742,
45303
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},
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"dataPointInteractionIds": [
1612
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"refIds": [
871,
874,
883,
14845,
41742,
45303
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},
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"dataPointInteractionIds": [
90328
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45303
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},
{
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"dataPointInteractionIds": [
90327
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871,
45303
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},
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90357
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45303
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},
{
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1707
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871,
45303
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},
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1708
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888
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90302
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14845,
41742,
45303
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"dataPointInteractionIds": [
1615
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874,
14845,
41742,
45303
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"dataPointInteractionIds": [
90324
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45303
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},
{
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90325
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45303
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},
{
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90356
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45303
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},
{
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"dataPointInteractionIds": [
89599
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45303
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},
{
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1712
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888
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},
{
"targetId": 22,
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"dataPointInteractionIds": [
1655
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871,
877,
881,
882,
883,
45304,
46755
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{
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"affinity": "8.1 - 9.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1692
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"refIds": [
858,
871,
881,
45304
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},
{
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"dataPointInteractionIds": [
1745
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858,
871,
881,
45304
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{
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"dataPointInteractionIds": [
1628
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45304,
46755
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"dataPointInteractionIds": [
1672
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871,
45304
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},
{
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"dataPointInteractionIds": [
1725
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871,
45304
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},
{
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"dataPointInteractionIds": [
1641
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858,
882,
45304
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
1682
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"refIds": [
858,
45304
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},
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"affinity": "6.3 - 6.7",
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"dataPointInteractionIds": [
1736
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"refIds": [
858,
45304
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},
{
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"ligandName": "phentolamine",
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"affinity": "8.2 - 8.3",
"affinityParameter": "pKi",
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1645
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871,
45304
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1646
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876
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1685
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871,
45304
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1739
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871,
45304
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90394
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45309
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1767
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948,
949,
45305
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1797
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35070,
45317
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1825
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986,
990,
14874
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{
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"affinity": "9.0 - 9.9",
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"dataPointInteractionIds": [
1649
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"refIds": [
858,
871,
877,
881,
882,
45304
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},
{
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1648
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876
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{
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"dataPointInteractionIds": [
1686
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858,
871,
881,
45304
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"dataPointInteractionIds": [
1740
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"refIds": [
858,
871,
881,
45304
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{
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1769
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948,
949,
45305
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{
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"dataPointInteractionIds": [
1798
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"refIds": [
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948,
949,
45305
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},
{
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1827
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948,
949,
45305
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},
{
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"affinity": "7.7 - 8.6",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90300
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"refIds": [
14845,
41742,
45303
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{
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"dataPointInteractionIds": [
1613
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"refIds": [
871,
874,
883,
14845,
28114,
41742,
45303
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},
{
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"affinity": "9.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90323
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"refIds": [
45303
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},
{
"targetId": 23,
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"dataPointInteractionIds": [
1659
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"refIds": [
871,
45303
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},
{
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90351
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45303
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},
{
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1697
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871,
28114,
45303
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},
{
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1709
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888
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},
{
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"dataPointInteractionIds": [
90390,
90392,
90391
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45309,
45309
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},
{
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90389
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45309
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},
{
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"dataPointInteractionIds": [
1752
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"refIds": [
944,
945,
45309
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},
{
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90436,
90437
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45309,
45309
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},
{
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90435
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45309
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},
{
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"dataPointInteractionIds": [
1781
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944,
945,
45309
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},
{
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90475
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45309,
45310
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{
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45309,
45310
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1809
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944,
945,
45309,
45310
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},
{
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90510
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14875
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},
{
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"dataPointInteractionIds": [
84159
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1051,
14875
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{
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90542
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14875
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},
{
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84161
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986,
1051,
14875
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},
{
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90568
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14875
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},
{
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1910
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1022,
1051,
1067
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},
{
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12710
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1067
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},
{
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12711
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1067
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},
{
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"dataPointInteractionIds": [
1693
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"refIds": [
888
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},
{
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90354
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45303
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},
{
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1706
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888
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},
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90417,
90415
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45309,
45309
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45309
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},
{
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1749
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944,
945,
946,
45309
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{
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"dataPointInteractionIds": [
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90462
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45309,
45309
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"dataPointInteractionIds": [
90461
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45309
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},
{
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"dataPointInteractionIds": [
1778
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"refIds": [
944,
945,
946,
45309
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},
{
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90495
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945,
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45309
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45309
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45309
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45309
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13896
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11740
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},
{
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1748
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1777
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90408
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90421,
90420
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90448
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1808
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1838
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14875
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1023,
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1067
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1885
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1879
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1904
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1575
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1576,
1583
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2096
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2095
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1655
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1665,
1672,
1685,
1688,
1689,
1690
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13152
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2512
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2823,
2825,
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2573
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2822
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2628
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2822
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},
{
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2698
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2770
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},
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"dataPointInteractionIds": [
2552
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2823,
2831
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},
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"affinity": "8.4 - 8.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2606
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2823,
2831
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},
{
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"dataPointInteractionIds": [
2563
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2822,
2828,
2833
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},
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"dataPointInteractionIds": [
2619
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"refIds": [
2822,
2828,
2833
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},
{
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14027
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2833,
2954
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},
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2570,
2569
],
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2828,
2829,
2835
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},
{
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2625
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2829
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},
{
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2576
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2822,
2828
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},
{
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2577
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2829
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},
{
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"affinity": "7.1 - 7.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2631
],
"refIds": [
2822,
2828
]
},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2632
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2829
]
},
{
"targetId": 221,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1013,
"ligandName": "17β-estradiol",
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"selectivity": "Not Determined",
"affinity": "8.2 - 8.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2734
],
"refIds": [
3191,
3194
]
},
{
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"primaryTarget": false,
"ligandId": 1015,
"ligandName": "fulvestrant",
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"selectivity": "Not Determined",
"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2736
],
"refIds": [
3194
]
},
{
"targetId": 221,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1016,
"ligandName": "tamoxifen",
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"action": "Full agonist",
"affinity": "6.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2737
],
"refIds": [
3194
]
},
{
"targetId": 222,
"targetName": "FPR1",
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"primaryTarget": false,
"ligandId": 1024,
"ligandName": "cyclosporin A",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.2 - 6.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
2745
],
"refIds": [
3226
]
},
{
"targetId": 225,
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"ligandAsTargetId": 0,
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"ligandId": 1056,
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
2778
],
"refIds": [
3265
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},
{
"targetId": 242,
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"ligandId": 1084,
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"action": "Full agonist",
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"affinity": "4.3 - 6.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2816
],
"refIds": [
3440,
3441
]
},
{
"targetId": 246,
"targetName": "ghrelin receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 1092,
"ligandName": "pralmorelin",
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"selectivity": "Not Determined",
"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2832
],
"refIds": [
3457
]
},
{
"targetId": 249,
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"ligandId": 1133,
"ligandName": "liraglutide",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "10.5",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
91912
],
"refIds": [
50725
]
},
{
"targetId": 249,
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"primaryTarget": true,
"ligandId": 1133,
"ligandName": "liraglutide",
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"action": "Full agonist",
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"affinity": "10.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
2875
],
"refIds": [
3586
]
},
{
"targetId": 249,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79371
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"refIds": [
24219
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2877
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3585
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2878
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3585
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},
{
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
2889
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"refIds": [
3609
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},
{
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"ligandId": 1157,
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
79218
],
"refIds": [
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},
{
"targetId": 254,
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"ligandId": 1159,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
2903
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"refIds": [
3810,
3811
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},
{
"targetId": 256,
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"targetSpecies": "Rat",
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"ligandId": 1175,
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"action": "Full agonist",
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"affinity": "9.1",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
2922
],
"refIds": [
3935
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},
{
"targetId": 256,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2921
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"refIds": [
3957
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},
{
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"affinity": "9.3 - 9.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2924
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"refIds": [
3956
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2923
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3956
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2935
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3957
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},
{
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"affinity": "8.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
8789
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"refIds": [
14111
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},
{
"targetId": 256,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2937
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"refIds": [
3957,
3962,
3967
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},
{
"targetId": 262,
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"ligandId": 1214,
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"affinity": "8.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2963
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"refIds": [
4047
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},
{
"targetId": 262,
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"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2974
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"refIds": [
3990
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},
{
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"affinity": "7.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2979
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"refIds": [
4005
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},
{
"targetId": 262,
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"dataPointInteractionIds": [
2980
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4005
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},
{
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"affinity": "8.7 - 9.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2991
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"refIds": [
4005,
4047
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},
{
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"dataPointInteractionIds": [
2998
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"refIds": [
3990,
4005
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},
{
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"affinity": "5.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
3010
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"refIds": [
4080
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},
{
"targetId": 263,
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"dataPointInteractionIds": [
79483
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24306
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},
{
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"affinity": "6.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
3014
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"refIds": [
4080
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
9205
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"refIds": [
19068
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},
{
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
3203
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"refIds": [
4327,
4331
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
3217
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"refIds": [
4359
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},
{
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"dataPointInteractionIds": [
3227
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"refIds": [
4359,
4371,
4372
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},
{
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
3241
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"refIds": [
4327
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},
{
"targetId": 287,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
3262
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"refIds": [
4400
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},
{
"targetId": 288,
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5198
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5216,
5225
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3770
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5246
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3886
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5246,
5330
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5246
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3795
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5246
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5246
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5246
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5290
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3796
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5246
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3880
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5246
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5296
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3938
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14678
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3937
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5290
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3797
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5246
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5246
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3953
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5246
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3798
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5246
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5330
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5246
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3811
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5246
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3802
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3810
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5290
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3901
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5246,
5247,
5299,
5300,
5330
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5295,
5296
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5246
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5290
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3813
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3903
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5247,
5300
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5241
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3958
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5246,
31515
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49996
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79485
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24254
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3881
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5330
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5241
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79484
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24254
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3897
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5246,
5330
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3924
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5246
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3925
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5246
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4018
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4031
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5752
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32301
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5801
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13922
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12011
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{
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79944,
4088
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5847,
24648
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4102
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5856
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4259
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6188
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4323
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6284
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4322
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6202
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4321
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6224
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83775
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6391
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4376
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6202
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},
{
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4375
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6224
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},
{
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4417
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6202
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},
{
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76996
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6224
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},
{
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4416
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6224
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},
{
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"dataPointInteractionIds": [
77068
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19501
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},
{
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4468
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6412
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},
{
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4469
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6202
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},
{
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4467
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6224
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},
{
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"dataPointInteractionIds": [
78811
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23120,
31462
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},
{
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"dataPointInteractionIds": [
4532
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6202
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},
{
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4260
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6167,
6188,
6205
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},
{
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4296
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6214
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{
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4297
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6209
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{
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"dataPointInteractionIds": [
4325
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6205
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},
{
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4326
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6202,
6229
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},
{
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4324
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6224
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{
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"dataPointInteractionIds": [
4378
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6204,
6205,
6336
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{
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4377
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6202,
6229,
6291
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4379
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6224
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},
{
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76955
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6204,
19374,
19375
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{
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76956
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19375
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{
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76954
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6205
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},
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76978
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6202
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{
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4418
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6202
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},
{
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76995
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6224
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},
{
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"dataPointInteractionIds": [
76993,
76990,
76989
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6224,
19370,
19373,
19373,
19375,
19375
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4420
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6224
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},
{
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77067
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"refIds": [
19501
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},
{
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"dataPointInteractionIds": [
4470
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6204,
6205,
6336,
6412,
19505
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},
{
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77080
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6202
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},
{
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"dataPointInteractionIds": [
4471
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6202,
6229
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4472
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6224
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},
{
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4508
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6205,
6454
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4509
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6202
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{
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4552
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6205
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"dataPointInteractionIds": [
4272
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6188,
6205,
19374
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4342
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6205,
6284
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4344
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6202
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},
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4343
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6224
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
4393
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6224
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},
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4392
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6205
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4394
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6202
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"dataPointInteractionIds": [
76965,
76966
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6205,
19374
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{
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4440
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6202
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},
{
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77009
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6224
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},
{
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"dataPointInteractionIds": [
77008
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6224
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},
{
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"ligandId": 1895,
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
77078
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19374
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},
{
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"affinity": "4.6 - 6.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4487
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6205,
6412,
19374
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},
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4486
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6202
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},
{
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4524
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6205
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},
{
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"dataPointInteractionIds": [
4544
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6204,
6205
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},
{
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4543
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6202
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},
{
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4564
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6205
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},
{
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"targetSpecies": "Human",
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"dataPointInteractionIds": [
4307
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6214,
6219
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{
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"dataPointInteractionIds": [
4306
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6209,
6220
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
4330
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"refIds": [
6284
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},
{
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"dataPointInteractionIds": [
4475
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6412
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},
{
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"dataPointInteractionIds": [
84146
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"refIds": [
32248
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},
{
"targetId": 341,
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"dataPointInteractionIds": [
4397
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6205
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},
{
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"affinity": "6.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
76960
],
"refIds": [
6205
]
},
{
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"dataPointInteractionIds": [
4489
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6205
]
},
{
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"affinity": "5.3",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
4516
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"refIds": [
6455
]
},
{
"targetId": 344,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
4525
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6205
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},
{
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"ligandId": 1961,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
4526
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"refIds": [
6205
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},
{
"targetId": 355,
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"ligandId": 2018,
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"affinity": "8.0",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
4627
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"refIds": [
6656
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},
{
"targetId": 356,
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"dataPointInteractionIds": [
14325
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"refIds": [
18592,
18593
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},
{
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"dataPointInteractionIds": [
4697
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6656
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},
{
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"dataPointInteractionIds": [
14327
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18593
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},
{
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"dataPointInteractionIds": [
14326
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18592
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},
{
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"dataPointInteractionIds": [
4775
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6656
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},
{
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"dataPointInteractionIds": [
4875
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6656
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},
{
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"affinity": "6.9 - 9.1",
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"dataPointInteractionIds": [
4643
],
"refIds": [
6649
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},
{
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"dataPointInteractionIds": [
4644
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6649
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},
{
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4642
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6646,
6647,
6648,
6655,
6690
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{
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4726
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6645
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},
{
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4725
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6649
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},
{
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4724
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6646,
6647,
6648,
6655
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},
{
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"dataPointInteractionIds": [
4832
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6646,
6647,
6648,
6649,
6655,
6690
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},
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4831
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6649
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},
{
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"dataPointInteractionIds": [
4691
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6646,
6655
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},
{
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"affinity": "6.1 - 9.2",
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"dataPointInteractionIds": [
4693
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6649
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
4692
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6649
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},
{
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"dataPointInteractionIds": [
4770
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6646,
6647,
6655
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{
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"dataPointInteractionIds": [
4771
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6649
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},
{
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4871
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6646,
6647,
6648,
6649,
6655,
6690
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{
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4870
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6649
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},
{
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"dataPointInteractionIds": [
4696
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6649
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},
{
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4695
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6649
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},
{
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4694
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6646,
6647,
6648,
6655,
6658,
6690
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},
{
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
4774
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6645
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
4773
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6649
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},
{
"targetId": 357,
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4772
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6646,
6647,
6648,
6655,
6658,
6696
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},
{
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"affinity": "7.7 - 9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4873
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"refIds": [
6704
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},
{
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"action": "Full agonist",
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"affinity": "7.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4872
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"refIds": [
6649
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},
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6647,
6648,
6649,
6655,
6658,
6690
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19218
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19218
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7004,
19584
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5004
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6983,
6995
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5002
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6983,
6984
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7138,
7162,
7163,
7164,
7165,
7166,
7167,
7168,
7169,
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7171
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{
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7164,
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7170,
7171,
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7163,
7164,
7165,
7166,
7167,
7168,
7170,
7171,
7172,
7277
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{
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7138,
7162,
7164,
7166,
7168,
7171,
7174
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5109
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7138,
7164,
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7168,
7219
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5154
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7138,
7164,
7166,
7168,
7172,
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},
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5219
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7171,
7172,
7174,
7219,
7349,
7350
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},
{
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5220
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7174
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{
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5057
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7138,
7162,
7163,
7164,
7167,
7168
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},
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5056
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7172
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},
{
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5115
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7163,
7164,
7167,
7168
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{
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5116
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7168
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},
{
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5162
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7138,
7163,
7164,
7167,
7168,
7172,
7277,
7278
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},
{
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5163
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7278
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},
{
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5226
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7172,
7349
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},
{
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"dataPointInteractionIds": [
5079
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7138,
7166
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},
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79010
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23511
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5090
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7174,
7178,
7181
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5138
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7178
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5198
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7174,
7178
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5259
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7171,
7174,
7178,
7181,
7349
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5258
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7174
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{
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5104
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7170
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5103
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7170
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78601
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7170
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},
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5215
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7170
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},
{
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89249
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44762
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},
{
"targetId": 679,
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89364
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44762
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
90315
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"refIds": [
45304
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},
{
"targetId": 22,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
90314
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45304
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},
{
"targetId": 275,
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"dataPointInteractionIds": [
83859
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31712
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},
{
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83860
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31712
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},
{
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2203
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1941
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},
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2221
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1941,
1976,
1977
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13925
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18070
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{
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13976
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2579
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},
{
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89282
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47652
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},
{
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1173,
27931
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{
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1953
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1244,
1247
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89344
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{
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{
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18500
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14053
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18500
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},
{
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14057
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18500
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{
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91454
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{
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89442
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37269
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},
{
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44839
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},
{
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37269,
37271,
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},
{
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89441
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{
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{
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{
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37269,
37271,
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32324,
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77771
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77791
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"dataPointInteractionIds": [
8149
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14679
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},
{
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8150
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},
{
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"affinityParameter": "pKi",
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14499
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14679
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},
{
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"dataPointInteractionIds": [
90553
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"refIds": [
14875
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},
{
"targetId": 29,
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8041
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14875
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},
{
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"dataPointInteractionIds": [
90515
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14875
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},
{
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14875,
24554
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},
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24555,
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45319,
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},
{
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},
{
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82042
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27687
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},
{
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82043
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27687
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},
{
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8168
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15258,
25008
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},
{
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"affinity": "7.2",
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78352
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3089
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},
{
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3089
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},
{
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"dataPointInteractionIds": [
78810
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3089
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},
{
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"dataPointInteractionIds": [
8198
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13958
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},
{
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"affinity": "9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
8199
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14681
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},
{
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78383
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22050
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},
{
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"affinity": "8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79720
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4375
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},
{
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"affinity": "7.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79721
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"refIds": [
4375
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79723
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24470
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79722
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4375
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},
{
"targetId": 269,
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"affinity": "8.1 - 10.0",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
77769,
77092
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"refIds": [
4212,
4213,
4213
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},
{
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"affinity": "7.1 - 8.8",
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"dataPointInteractionIds": [
77962
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"refIds": [
4224,
19576
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},
{
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"affinityParameter": "pA2",
"dataPointInteractionIds": [
77795
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"refIds": [
37315
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},
{
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"affinity": "5.4",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
77794
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"refIds": [
4175
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},
{
"targetId": 203,
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"ligandId": 3639,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
8096
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"refIds": [
12138
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},
{
"targetId": 252,
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"dataPointInteractionIds": [
8884
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3624
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},
{
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"affinity": "9.3 - 10.1",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83915
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"refIds": [
31772
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},
{
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83911
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31772
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},
{
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83912
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31771,
31772
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},
{
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83913
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31771
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},
{
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9034
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},
{
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9035
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},
{
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"affinityParameter": "",
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9039
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
9041
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14773,
45088
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},
{
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"affinityParameter": "",
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9052
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},
{
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"affinity": "",
"affinityParameter": "",
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79226
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},
{
"targetId": 5,
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"dataPointInteractionIds": [
9077
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14820
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},
{
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9157
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18098
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},
{
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9180
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14945
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},
{
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9181
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14946
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},
{
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},
{
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79756
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14946
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},
{
"targetId": 347,
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9403
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15256
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},
{
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"affinityParameter": "",
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84111
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32074
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},
{
"targetId": 89,
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
13928
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15028
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},
{
"targetId": 109,
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13982
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2579,
14916
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{
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"dataPointInteractionIds": [
85913
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36781
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},
{
"targetId": 19,
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"dataPointInteractionIds": [
85912
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"refIds": [
36781
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},
{
"targetId": 669,
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"dataPointInteractionIds": [
89306
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44941
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},
{
"targetId": 682,
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4124
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{
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4125
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4164
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6011
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91704
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},
{
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{
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14012
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},
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14013
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18340
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},
{
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},
{
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90412
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945,
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45309
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},
{
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90451
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45309
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},
{
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79544
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45309
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},
{
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"dataPointInteractionIds": [
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90491
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45309,
45310
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45310
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},
{
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"dataPointInteractionIds": [
90489
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},
{
"targetId": 319,
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"affinityParameter": "pIC50",
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79546
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24263
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},
{
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"affinity": "7.2 - 7.9",
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"dataPointInteractionIds": [
77242
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"refIds": [
2825
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},
{
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"affinity": "6.8 - 7.8",
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"dataPointInteractionIds": [
77243
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"refIds": [
2825
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},
{
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"affinity": "8.9",
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90305
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"refIds": [
45303
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},
{
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90304
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45303
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},
{
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90424
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45309
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},
{
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"dataPointInteractionIds": [
90423
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45309
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},
{
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90499
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45309
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},
{
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90498
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45309
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},
{
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90497
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45309
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},
{
"targetId": 169,
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13894
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11740
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},
{
"targetId": 169,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
13895
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"refIds": [
11740
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},
{
"targetId": 156,
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
13947
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"refIds": [
13076
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},
{
"targetId": 660,
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"affinityParameter": "",
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89247
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"refIds": [
44762
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},
{
"targetId": 256,
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14023
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18362
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},
{
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"dataPointInteractionIds": [
14025
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"refIds": [
18364
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},
{
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"dataPointInteractionIds": [
14026
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18364
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},
{
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14232
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18503
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},
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14249
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},
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14270
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14283
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},
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14090
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},
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14091
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14132
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18561
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14133
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18523,
18540
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14175
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14204
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18561
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},
{
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"affinity": "8.6",
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14341
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"refIds": [
18671
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},
{
"targetId": 360,
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"affinityParameter": "pKi",
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14392
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18860
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"refIds": [
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31453,
50035
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},
{
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31453
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},
{
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},
{
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19374
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},
{
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77076
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19374
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},
{
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19374,
42101
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},
{
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"dataPointInteractionIds": [
77064
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19374
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},
{
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
76946
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19433
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
77205
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"refIds": [
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},
{
"targetId": 114,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
83566
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"refIds": [
30945
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},
{
"targetId": 188,
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"affinity": "8.5",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
77214
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"refIds": [
20173
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},
{
"targetId": 262,
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79555
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24341
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},
{
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78812
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"refIds": [
25087,
27096
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},
{
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"ligandId": 6510,
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
78386
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"refIds": [
22057
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},
{
"targetId": 661,
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"affinity": "4.1",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89248
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"refIds": [
44919
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},
{
"targetId": 682,
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"ligandId": 6649,
"ligandName": "methimazole",
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"affinity": "4.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89324
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"refIds": [
44949
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},
{
"targetId": 682,
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"ligandId": 6650,
"ligandName": "propylthiouracil",
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"action": "Agonist",
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"affinity": "5.7",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89326
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"refIds": [
44947
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},
{
"targetId": 13,
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"ligandId": 6687,
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"affinity": "5.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
80070
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"refIds": [
25124
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},
{
"targetId": 14,
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"ligandId": 6687,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
80078
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"refIds": [
25124
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},
{
"targetId": 34,
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"ligandId": 6896,
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"affinity": "8.2 - 8.6",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
78845
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"refIds": [
23308
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},
{
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"ligandId": 6953,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
89244
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"refIds": [
44762
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},
{
"targetId": 247,
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79225
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},
{
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79217
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},
{
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79215
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},
{
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"affinity": "7.6 - 11.1",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
2102
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"refIds": [
1664,
1671,
1672,
1691
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},
{
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
89499
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"refIds": [
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},
{
"targetId": 44,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2113
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"refIds": [
1693
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},
{
"targetId": 46,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
89501
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2131
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"refIds": [
1693
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},
{
"targetId": 239,
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79049
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23531
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},
{
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79562
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24061
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},
{
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"affinityParameter": "",
"dataPointInteractionIds": [
79224
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"refIds": [
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},
{
"targetId": 250,
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"affinity": "10.7",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79230
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"refIds": [
28504,
50725
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},
{
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79392
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},
{
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
89318
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44762
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},
{
"targetId": 318,
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"affinity": "6.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79401
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"refIds": [
24253
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},
{
"targetId": 319,
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"affinity": "8.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79400
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"refIds": [
24253
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},
{
"targetId": 317,
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"affinity": "7.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79403
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"refIds": [
24254
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},
{
"targetId": 318,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79404
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"refIds": [
24254
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79402
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24254
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
83687
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"refIds": [
18516
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},
{
"targetId": 28,
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24341
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{
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"dataPointInteractionIds": [
79271
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"refIds": [
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45304,
46755
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79269
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"refIds": [
24050,
45304
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},
{
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"dataPointInteractionIds": [
79270
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45304
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},
{
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
86639
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"refIds": [
38134
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},
{
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
86640
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38134
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},
{
"targetId": 25,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79277
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"refIds": [
24058
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},
{
"targetId": 27,
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"action": "Agonist",
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"affinity": "7.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79278
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"refIds": [
24058,
45309
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},
{
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24062
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{
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79286
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24062
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},
{
"targetId": 16,
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79287
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24062
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{
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24062
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{
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89616
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50938,
50939
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79578
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45304
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{
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79297
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24072
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},
{
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"affinity": "",
"affinityParameter": "",
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89274
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44762
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},
{
"targetId": 671,
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"affinityParameter": "",
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89308
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44762
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},
{
"targetId": 22,
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79380
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45304,
46755
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{
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"dataPointInteractionIds": [
79381
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45304
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},
{
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"dataPointInteractionIds": [
79382
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45304
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},
{
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"affinityParameter": "pIC50",
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79384
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"refIds": [
24243
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},
{
"targetId": 28,
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"ligandName": "esmolol",
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"affinity": "6.7 - 6.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79582
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"refIds": [
45312
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},
{
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79388
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24246
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},
{
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79389
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24246
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},
{
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79397
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"refIds": [
24252
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},
{
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79398
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24252
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},
{
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"affinityParameter": "pKi",
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79399
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24252
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},
{
"targetId": 262,
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"affinityParameter": "pKi",
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79718
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24468
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},
{
"targetId": 262,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79407
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"refIds": [
24257
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},
{
"targetId": 22,
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"affinity": "7.5 - 7.9",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
90312
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45303
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},
{
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"affinity": "7.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
90311
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"refIds": [
45303
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},
{
"targetId": 24,
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45304
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},
{
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14865
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{
"targetId": 29,
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},
{
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79408
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24258
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},
{
"targetId": 319,
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79409
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24259
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},
{
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"affinityParameter": "pKi",
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79410
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24260
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},
{
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"action": "Agonist",
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"affinity": "5.0",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79417
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"refIds": [
24263
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},
{
"targetId": 318,
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"action": "Agonist",
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"affinity": "5.6",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79416
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24263
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},
{
"targetId": 319,
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"affinity": "6.5",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79415
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24263
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},
{
"targetId": 1,
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"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82616
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"refIds": [
24264
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},
{
"targetId": 6,
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"affinityParameter": "pKi",
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79419
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24264
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},
{
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"affinityParameter": "pKi",
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82617
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24264
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},
{
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82618
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24264
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},
{
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79418
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24264
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},
{
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82619
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24264
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},
{
"targetId": 262,
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84299
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32864
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},
{
"targetId": 6,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79427
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24048
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},
{
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24048
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},
{
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},
{
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45305
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24266
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},
{
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24048,
45305
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},
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"affinity": "9.1 - 9.2",
"affinityParameter": "pKi",
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87392
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14875
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},
{
"targetId": 28,
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"targetSpecies": "Rabbit",
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"affinity": "8.1 - 8.7",
"affinityParameter": "pIC50",
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82185
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28123
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},
{
"targetId": 29,
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"affinity": "7.9 - 8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87393
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"refIds": [
14875,
40016
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},
{
"targetId": 30,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7246,
"ligandName": "nebivolol",
"type": "Antagonist",
"action": "Antagonist",
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"affinity": "5.7 - 7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87394
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"refIds": [
14875,
40016
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},
{
"targetId": 6,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7247,
"ligandName": "nefazodone",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79430
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"refIds": [
24269
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},
{
"targetId": 29,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7250,
"ligandName": "orciprenaline",
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"action": "Agonist",
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"affinity": "5.3",
"affinityParameter": "pKd",
"dataPointInteractionIds": [
79433
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"refIds": [
24270
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},
{
"targetId": 16,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7257,
"ligandName": "oxyphenonium",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
86716
],
"refIds": [
38215
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},
{
"targetId": 24,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7268,
"ligandName": "phenoxybenzamine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
90361
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"refIds": [
45304
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},
{
"targetId": 26,
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"ligandId": 7268,
"ligandName": "phenoxybenzamine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
90470
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"refIds": [
45305
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},
{
"targetId": 26,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7268,
"ligandName": "phenoxybenzamine",
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"selectivity": "Not Determined",
"affinity": "8.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79712
],
"refIds": [
2961
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},
{
"targetId": 3315,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7270,
"ligandName": "phenylbutazone",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
91561
],
"refIds": [
49730
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},
{
"targetId": 214,
"targetName": "D1 receptor",
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"primaryTarget": false,
"ligandId": 7279,
"ligandName": "prochlorperazine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79590
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"refIds": [
24341
]
},
{
"targetId": 215,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7279,
"ligandName": "prochlorperazine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79591
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"refIds": [
24341
]
},
{
"targetId": 216,
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"primaryTarget": true,
"ligandId": 7279,
"ligandName": "prochlorperazine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79592
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"refIds": [
24341
]
},
{
"targetId": 217,
"targetName": "D4 receptor",
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"targetSpecies": "Human",
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"ligandId": 7279,
"ligandName": "prochlorperazine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79593
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"refIds": [
24341
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7281,
"ligandName": "promazine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79716
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"refIds": [
24464
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},
{
"targetId": 216,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7281,
"ligandName": "promazine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79717
],
"refIds": [
24464
]
},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7282,
"ligandName": "promethazine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79719
],
"refIds": [
24469
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7295,
"ligandName": "ropinirole",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79444
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"refIds": [
24282
]
},
{
"targetId": 216,
"targetName": "D3 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7295,
"ligandName": "ropinirole",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79445
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"refIds": [
24282
]
},
{
"targetId": 28,
"targetName": "β1-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7297,
"ligandName": "sotalol",
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"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "5.8 - 6.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79595
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"refIds": [
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},
{
"targetId": 29,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7297,
"ligandName": "sotalol",
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"action": "Antagonist",
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"affinity": "6.5 - 6.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79596
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"refIds": [
990
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},
{
"targetId": 22,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7302,
"ligandName": "terazosin",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.9 - 8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79451
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"refIds": [
24285,
45304,
46755
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},
{
"targetId": 23,
"targetName": "α1B-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7302,
"ligandName": "terazosin",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.0 - 8.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79452
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"refIds": [
24285,
45304
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},
{
"targetId": 24,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7302,
"ligandName": "terazosin",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.7 - 8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79450
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"refIds": [
24285,
45304
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},
{
"targetId": 25,
"targetName": "α2A-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7308,
"ligandName": "tizanidine",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.8 - 8.4",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90400,
90401
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"refIds": [
45309,
45309
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},
{
"targetId": 25,
"targetName": "α2A-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7308,
"ligandName": "tizanidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.6",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
90399
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"refIds": [
45309
]
},
{
"targetId": 25,
"targetName": "α2A-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7308,
"ligandName": "tizanidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
89601
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"refIds": [
45309
]
},
{
"targetId": 26,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7308,
"ligandName": "tizanidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.3 - 7.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90465,
90466
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"refIds": [
45309,
45309
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},
{
"targetId": 26,
"targetName": "α2B-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7308,
"ligandName": "tizanidine",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.8",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
90464
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"refIds": [
45309
]
},
{
"targetId": 26,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7308,
"ligandName": "tizanidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
89605
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"refIds": [
45309
]
},
{
"targetId": 25,
"targetName": "α2A-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7310,
"ligandName": "tolazoline",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79713
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"refIds": [
945
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},
{
"targetId": 26,
"targetName": "α2B-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7310,
"ligandName": "tolazoline",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "5.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79714
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"refIds": [
945
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},
{
"targetId": 27,
"targetName": "α2C-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7310,
"ligandName": "tolazoline",
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"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "5.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79715
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"refIds": [
945
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7315,
"ligandName": "trihexyphenidyl",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79597
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"refIds": [
24341
]
},
{
"targetId": 262,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7318,
"ligandName": "tripelennamine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.0",
"affinityParameter": "pKd",
"dataPointInteractionIds": [
79462
],
"refIds": [
24294
]
},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Human",
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"ligandId": 7318,
"ligandName": "tripelennamine",
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"action": "Antagonist",
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"affinity": "7.4",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79461
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"refIds": [
24294
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},
{
"targetId": 14,
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"action": "Antagonist",
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"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87958
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41877
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},
{
"targetId": 15,
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"targetSpecies": "Human",
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"ligandId": 7319,
"ligandName": "tropicamide",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79598
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"refIds": [
41877
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},
{
"targetId": 16,
"targetName": "M4 receptor",
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"targetSpecies": "Human",
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"ligandName": "tropicamide",
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"action": "Antagonist",
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"affinity": "6.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
86715
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"refIds": [
38215
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},
{
"targetId": 17,
"targetName": "M5 receptor",
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"targetSpecies": "Human",
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"ligandId": 7319,
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"action": "Antagonist",
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"affinity": "6.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87972
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41877
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},
{
"targetId": 1,
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"action": "Partial agonist",
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"affinity": "7.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79599
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"refIds": [
24039
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},
{
"targetId": 2,
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"affinity": "7.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79600
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"refIds": [
24039
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},
{
"targetId": 3,
"targetName": "5-HT1D receptor",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "5.4",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
80011
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"refIds": [
24428
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},
{
"targetId": 10,
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79603
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24039
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},
{
"targetId": 11,
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"dataPointInteractionIds": [
79604
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24039
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},
{
"targetId": 12,
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24039
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},
{
"targetId": 219,
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"affinityParameter": "pIC50",
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"refIds": [
24040
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},
{
"targetId": 220,
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"ligandId": 7352,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.4",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79263
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"refIds": [
24040
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},
{
"targetId": 29,
"targetName": "β2-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7353,
"ligandName": "vilanterol",
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"action": "Agonist",
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"affinity": "9.4",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79608
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"refIds": [
24357
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7354,
"ligandName": "umeclidinium",
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24042,
28686
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},
{
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24042,
28686
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},
{
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24042,
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},
{
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82417
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28686
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},
{
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82424
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"refIds": [
28686
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},
{
"targetId": 249,
"targetName": "GLP-1 receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
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"ligandName": "albiglutide",
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"action": "Agonist",
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79369
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"refIds": [
24216
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},
{
"targetId": 249,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7387,
"ligandName": "lixisenatide",
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"action": "Agonist",
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"affinity": "8.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79370
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"refIds": [
24217
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7391,
"ligandName": "droxidopa",
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"action": "Antagonist",
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"affinity": "7.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87957
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"refIds": [
41877
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},
{
"targetId": 287,
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"targetSpecies": "Human",
"primaryTarget": true,
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"ligandName": "tasimelteon",
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"affinityParameter": "pKi",
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79374
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"refIds": [
37022
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},
{
"targetId": 288,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79375
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37022
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},
{
"targetId": 1,
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"ligandId": 7427,
"ligandName": "vilazodone",
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"action": "Partial agonist",
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"affinity": "9.5",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79692
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"refIds": [
24428
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},
{
"targetId": 1,
"targetName": "5-HT1A receptor",
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"targetSpecies": "Human",
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"ligandId": 7427,
"ligandName": "vilazodone",
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"selectivity": "Not Determined",
"affinity": "9.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79695
],
"refIds": [
24427
]
},
{
"targetId": 9,
"targetName": "5-HT4 receptor",
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"targetSpecies": "Human",
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"ligandName": "vilazodone",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.6",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79696
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"refIds": [
24428
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
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"ligandName": "vilazodone",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79693
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"refIds": [
24428
]
},
{
"targetId": 216,
"targetName": "D3 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7427,
"ligandName": "vilazodone",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79697
],
"refIds": [
24428
]
},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Human",
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"ligandId": 7427,
"ligandName": "vilazodone",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.5",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79698
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"refIds": [
24428
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},
{
"targetId": 13,
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7438,
"ligandName": "methacholine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.4",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79736
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"refIds": [
413,
24488
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},
{
"targetId": 14,
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7438,
"ligandName": "methacholine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79733
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"refIds": [
413,
24488
]
},
{
"targetId": 15,
"targetName": "M3 receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7438,
"ligandName": "methacholine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.9",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79735
],
"refIds": [
413,
24488
]
},
{
"targetId": 16,
"targetName": "M4 receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7438,
"ligandName": "methacholine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79734
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"refIds": [
413,
24488
]
},
{
"targetId": 17,
"targetName": "M5 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7438,
"ligandName": "methacholine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Non-selective",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
87969
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"refIds": [
413
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},
{
"targetId": 28,
"targetName": "β1-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7445,
"ligandName": "mirabegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "4.9 - 5.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79745
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"refIds": [
24498,
46740
]
},
{
"targetId": 29,
"targetName": "β2-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7445,
"ligandName": "mirabegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.0 - 5.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79746,
90655
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"refIds": [
24498,
24498,
46740
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},
{
"targetId": 29,
"targetName": "β2-adrenoceptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7445,
"ligandName": "mirabegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90656
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"refIds": [
46740
]
},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 7445,
"ligandName": "mirabegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.3 - 9.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90638,
90572
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"refIds": [
46740,
46740
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},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
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"targetSpecies": "Rat",
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"ligandId": 7445,
"ligandName": "mirabegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.7",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90573
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"refIds": [
46740
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},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7445,
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"action": "Agonist",
"selectivity": "Selective",
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79744
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"refIds": [
24498,
45320,
46740,
47054
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7449,
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"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "10.1 - 10.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79748
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"refIds": [
24507,
41876
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},
{
"targetId": 14,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7449,
"ligandName": "aclidinium",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "10.1",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79749
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"refIds": [
24507,
41876
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},
{
"targetId": 15,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7449,
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"action": "Antagonist",
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"affinity": "10.1 - 10.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79750
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"refIds": [
24507,
41876
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},
{
"targetId": 16,
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"targetSpecies": "Human",
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"ligandId": 7449,
"ligandName": "aclidinium",
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"action": "Antagonist",
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"affinity": "10.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87963
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"refIds": [
41876
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},
{
"targetId": 17,
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"targetSpecies": "Human",
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"ligandId": 7449,
"ligandName": "aclidinium",
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"action": "Antagonist",
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"affinity": "9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87971
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"refIds": [
41876
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},
{
"targetId": 344,
"targetName": "FP receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7451,
"ligandName": "tafluprost",
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"action": "Agonist",
"selectivity": "Selective",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
79752
],
"refIds": [
24510
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},
{
"targetId": 28,
"targetName": "β1-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7455,
"ligandName": "indacaterol",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79760
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"refIds": [
24521,
45319
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},
{
"targetId": 29,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7455,
"ligandName": "indacaterol",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.1",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90546
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"refIds": [
45319
]
},
{
"targetId": 29,
"targetName": "β2-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7455,
"ligandName": "indacaterol",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.4 - 7.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79761
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"refIds": [
24521,
45319
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": true,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.6 - 10.1",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79762
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"refIds": [
24527,
41875
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},
{
"targetId": 14,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.7 - 9.5",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79763
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"refIds": [
24527,
41875
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},
{
"targetId": 15,
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"targetSpecies": "Human",
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"ligandId": 7459,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.6 - 9.8",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79764
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"refIds": [
24527,
41875
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},
{
"targetId": 16,
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"targetSpecies": "Human",
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"ligandId": 7459,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.1 - 10.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79765
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"refIds": [
24527,
41875
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},
{
"targetId": 17,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7459,
"ligandName": "glycopyrrolate",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.9 - 9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79766
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"refIds": [
24527,
41875
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},
{
"targetId": 1,
"targetName": "5-HT1A receptor",
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"targetSpecies": "Rat",
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"action": "Partial agonist",
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"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79770
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"refIds": [
24531
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},
{
"targetId": 6,
"targetName": "5-HT2A receptor",
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"targetSpecies": "Rat",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79771
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"refIds": [
24531
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},
{
"targetId": 12,
"targetName": "5-HT7 receptor",
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"targetSpecies": "Human",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79769
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"refIds": [
24531
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},
{
"targetId": 25,
"targetName": "α2A-adrenoceptor",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.7 - 7.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79774
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"refIds": [
24531,
45305
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},
{
"targetId": 27,
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"targetSpecies": "Human",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.3 - 8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79773
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"refIds": [
24531,
45305
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},
{
"targetId": 215,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79772
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"refIds": [
24531
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},
{
"targetId": 317,
"targetName": "δ receptor",
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"targetSpecies": "Human",
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"ligandId": 7471,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79778
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"refIds": [
24536
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},
{
"targetId": 318,
"targetName": "κ receptor",
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"targetSpecies": "Human",
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"ligandId": 7471,
"ligandName": "alvimopan",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79779
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"refIds": [
24536
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},
{
"targetId": 319,
"targetName": "μ receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7471,
"ligandName": "alvimopan",
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"action": "Antagonist",
"selectivity": "Selective",
"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79780
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"refIds": [
24536
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},
{
"targetId": 319,
"targetName": "μ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7477,
"ligandName": "tapentadol",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79787
],
"refIds": [
24552
]
},
{
"targetId": 43,
"targetName": "CT receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7482,
"ligandName": "pramlintide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
81033
],
"refIds": [
24560
]
},
{
"targetId": 44,
"targetName": "AMY1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7482,
"ligandName": "pramlintide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.4 - 9.4",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
81031
],
"refIds": [
24560
]
},
{
"targetId": 45,
"targetName": "AMY2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7482,
"ligandName": "pramlintide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.6 - 8.9",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
81032
],
"refIds": [
24560
]
},
{
"targetId": 46,
"targetName": "AMY3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7482,
"ligandName": "pramlintide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.1 - 9.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79791
],
"refIds": [
24560
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "7.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82380
],
"refIds": [
28680,
28681
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82381
],
"refIds": [
28682
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79792
],
"refIds": [
24561
]
},
{
"targetId": 14,
"targetName": "M2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "6.9 - 7.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82390
],
"refIds": [
28680,
28681
]
},
{
"targetId": 14,
"targetName": "M2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79793
],
"refIds": [
24561
]
},
{
"targetId": 15,
"targetName": "M3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "7.7 - 8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82400
],
"refIds": [
28680,
28681
]
},
{
"targetId": 15,
"targetName": "M3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.9",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79794
],
"refIds": [
24561
]
},
{
"targetId": 16,
"targetName": "M4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "6.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82406
],
"refIds": [
28681
]
},
{
"targetId": 17,
"targetName": "M5 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7483,
"ligandName": "solifenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Non-selective",
"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82418
],
"refIds": [
28681
]
},
{
"targetId": 29,
"targetName": "β2-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7543,
"ligandName": "olodaterol",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Selective",
"affinity": "10.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79961
],
"refIds": [
24686
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7549,
"ligandName": "dosulepin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79970
],
"refIds": [
24715
]
},
{
"targetId": 14,
"targetName": "M2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7549,
"ligandName": "dosulepin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79971
],
"refIds": [
24715
]
},
{
"targetId": 15,
"targetName": "M3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7549,
"ligandName": "dosulepin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79972
],
"refIds": [
24715
]
},
{
"targetId": 16,
"targetName": "M4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7549,
"ligandName": "dosulepin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79973
],
"refIds": [
24715
]
},
{
"targetId": 17,
"targetName": "M5 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7549,
"ligandName": "dosulepin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79974
],
"refIds": [
24715
]
},
{
"targetId": 262,
"targetName": "H1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7549,
"ligandName": "dosulepin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79975
],
"refIds": [
24716
]
},
{
"targetId": 345,
"targetName": "IP receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7552,
"ligandName": "selexipag",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
83781
],
"refIds": [
19469
]
},
{
"targetId": 345,
"targetName": "IP receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7552,
"ligandName": "selexipag",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Selective",
"affinity": "6.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
83778
],
"refIds": [
19469
]
},
{
"targetId": 6,
"targetName": "5-HT2A receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7556,
"ligandName": "perospirone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "4.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79983
],
"refIds": [
3003
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7556,
"ligandName": "perospirone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79982
],
"refIds": [
3003
]
},
{
"targetId": 216,
"targetName": "D3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7556,
"ligandName": "perospirone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79985
],
"refIds": [
2828
]
},
{
"targetId": 217,
"targetName": "D4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7556,
"ligandName": "perospirone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "10.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79981
],
"refIds": [
24726
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7557,
"ligandName": "pipotiazine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79984
],
"refIds": [
24727
]
},
{
"targetId": 317,
"targetName": "δ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7563,
"ligandName": "methylnaltrexone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79989
],
"refIds": [
24254
]
},
{
"targetId": 318,
"targetName": "κ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7563,
"ligandName": "methylnaltrexone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79990
],
"refIds": [
24254
]
},
{
"targetId": 319,
"targetName": "μ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7563,
"ligandName": "methylnaltrexone",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79991
],
"refIds": [
24254
]
},
{
"targetId": 318,
"targetName": "κ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7591,
"ligandName": "butorphanol",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80049
],
"refIds": [
24946
]
},
{
"targetId": 319,
"targetName": "μ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7591,
"ligandName": "butorphanol",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80050
],
"refIds": [
24946
]
},
{
"targetId": 319,
"targetName": "μ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7595,
"ligandName": "levorphanol",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.9",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
80051
],
"refIds": [
24948
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7601,
"ligandName": "benzatropine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80058
],
"refIds": [
24953
]
},
{
"targetId": 14,
"targetName": "M2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7601,
"ligandName": "benzatropine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80059
],
"refIds": [
24953
]
},
{
"targetId": 663,
"targetName": "TAS2R7",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7608,
"ligandName": "cromoglicic acid",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "2.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89256
],
"refIds": [
44762
]
},
{
"targetId": 671,
"targetName": "TAS2R20",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7608,
"ligandName": "cromoglicic acid",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "4.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89307
],
"refIds": [
44762
]
},
{
"targetId": 360,
"targetName": "NK1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7623,
"ligandName": "fosaprepitant",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.9",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
80063
],
"refIds": [
25008
]
},
{
"targetId": 6,
"targetName": "5-HT2A receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7670,
"ligandName": "blonanserin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80136
],
"refIds": [
25267
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 7670,
"ligandName": "blonanserin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80135
],
"refIds": [
25267
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7671,
"ligandName": "cariprazine",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80137
],
"refIds": [
25269
]
},
{
"targetId": 216,
"targetName": "D3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7671,
"ligandName": "cariprazine",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "10.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80138
],
"refIds": [
25268
]
},
{
"targetId": 215,
"targetName": "D2 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7672,
"ligandName": "brexpiprazole",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "9.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80139
],
"refIds": [
25271
]
},
{
"targetId": 317,
"targetName": "δ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7691,
"ligandName": "eluxadoline",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80167
],
"refIds": [
25330
]
},
{
"targetId": 319,
"targetName": "μ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7691,
"ligandName": "eluxadoline",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80168
],
"refIds": [
25330
]
},
{
"targetId": 319,
"targetName": "μ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7691,
"ligandName": "eluxadoline",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80169
],
"refIds": [
25330
]
},
{
"targetId": 1,
"targetName": "5-HT1A receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 8182,
"ligandName": "flibanserin",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
81694
],
"refIds": [
26982
]
},
{
"targetId": 6,
"targetName": "5-HT2A receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 8182,
"ligandName": "flibanserin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
81695
],
"refIds": [
26982
]
},
{
"targetId": 239,
"targetName": "SMO",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 8199,
"ligandName": "sonidegib",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
81763
],
"refIds": [
23531
]
},
{
"targetId": 239,
"targetName": "SMO",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 8201,
"ligandName": "glasdegib",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.3",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
81765
],
"refIds": [
27018
]
},
{
"targetId": 317,
"targetName": "δ receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
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"ligandId": 8286,
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82213
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{
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{
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{
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{
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84222
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{
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84226
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32471
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{
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32471
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{
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91564
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49728
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},
{
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91565
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49728
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},
{
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},
{
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83313
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},
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30247
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28141
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83418
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41419
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},
{
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},
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89218
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{
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83502
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30814,
30815
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83503
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30814,
30815
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37556
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83684
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24726
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83685
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24726
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83686
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31075
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50060
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31322
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83756
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31400
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83757
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31400
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},
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31400
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41510
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31400
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31422
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37352
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83798
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31524
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"primaryTarget": true,
"ligandId": 9289,
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83800
],
"refIds": [
31525,
31526,
37353
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},
{
"targetId": 321,
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"targetSpecies": "Human",
"primaryTarget": false,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
89453
],
"refIds": [
42598
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},
{
"targetId": 321,
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"primaryTarget": true,
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"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
83821
],
"refIds": [
31585
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},
{
"targetId": 322,
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"primaryTarget": false,
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"ligandName": "lemborexant",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
89455
],
"refIds": [
42598
]
},
{
"targetId": 322,
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"targetSpecies": "Human",
"primaryTarget": true,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
83822
],
"refIds": [
31585
]
},
{
"targetId": 275,
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 9320,
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"action": "Agonist",
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83861
],
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31714
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},
{
"targetId": 277,
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"primaryTarget": false,
"ligandId": 9320,
"ligandName": "ponesimod",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
83862
],
"refIds": [
31714
]
},
{
"targetId": 278,
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"ligandId": 9320,
"ligandName": "ponesimod",
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"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "5.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
83863
],
"refIds": [
31714
]
},
{
"targetId": 279,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
83864
],
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31714
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},
{
"targetId": 275,
"targetName": "S1P1 receptor",
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"primaryTarget": false,
"ligandId": 9331,
"ligandName": "etrasimod",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
87669
],
"refIds": [
40917
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},
{
"targetId": 275,
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"primaryTarget": true,
"ligandId": 9331,
"ligandName": "etrasimod",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83886
],
"refIds": [
31744
]
},
{
"targetId": 278,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9331,
"ligandName": "etrasimod",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.8",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83887
],
"refIds": [
5685,
31744
]
},
{
"targetId": 279,
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"targetSpecies": "Human",
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"ligandId": 9331,
"ligandName": "etrasimod",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.6",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
83888
],
"refIds": [
31744
]
},
{
"targetId": 32,
"targetName": "C5a1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9450,
"ligandName": "avacopan",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
84131
],
"refIds": [
32151
]
},
{
"targetId": 344,
"targetName": "FP receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9635,
"ligandName": "latanoprostene bunod",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84471
],
"refIds": [
6205,
33427
]
},
{
"targetId": 13,
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"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9658,
"ligandName": "cevimeline",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84549
],
"refIds": [
33523
]
},
{
"targetId": 14,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9658,
"ligandName": "cevimeline",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84550
],
"refIds": [
33523
]
},
{
"targetId": 15,
"targetName": "M3 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9658,
"ligandName": "cevimeline",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84551
],
"refIds": [
33523
]
},
{
"targetId": 16,
"targetName": "M4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9658,
"ligandName": "cevimeline",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84552
],
"refIds": [
33523
]
},
{
"targetId": 249,
"targetName": "GLP-1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 9724,
"ligandName": "semaglutide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Selective",
"affinity": "11.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
84709
],
"refIds": [
33890
]
},
{
"targetId": 249,
"targetName": "GLP-1 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 9724,
"ligandName": "semaglutide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Selective",
"affinity": "9.4",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
84708
],
"refIds": [
33890
]
},
{
"targetId": 48,
"targetName": "CGRP receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9730,
"ligandName": "atogepant",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "10.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84718
],
"refIds": [
33909
]
},
{
"targetId": 102,
"targetName": "GPR35",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9743,
"ligandName": "lodoxamide",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
84734
],
"refIds": [
33965
]
},
{
"targetId": 246,
"targetName": "ghrelin receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 9745,
"ligandName": "macimorelin",
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"action": "Agonist",
"selectivity": "Selective",
"affinity": "7.8",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
84737
],
"refIds": [
33980
]
},
{
"targetId": 28,
"targetName": "β1-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9816,
"ligandName": "levosalbutamol",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "6.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90519
],
"refIds": [
14875
]
},
{
"targetId": 28,
"targetName": "β1-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9816,
"ligandName": "levosalbutamol",
"type": "Agonist",
"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "4.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
90518
],
"refIds": [
14875
]
},
{
"targetId": 25,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9868,
"ligandName": "lofexidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84982
],
"refIds": [
34614
]
},
{
"targetId": 26,
"targetName": "α2B-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9868,
"ligandName": "lofexidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84983
],
"refIds": [
34614
]
},
{
"targetId": 27,
"targetName": "α2C-adrenoceptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9868,
"ligandName": "lofexidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84984
],
"refIds": [
34614
]
},
{
"targetId": 344,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9875,
"ligandName": "sepetaprost",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.5",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
85044
],
"refIds": [
34774
]
},
{
"targetId": 344,
"targetName": "FP receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9875,
"ligandName": "sepetaprost",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85043
],
"refIds": [
34774
]
},
{
"targetId": 219,
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"targetSpecies": "Human",
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"ligandId": 10070,
"ligandName": "aprocitentan",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.7",
"affinityParameter": "pA2",
"dataPointInteractionIds": [
89503
],
"refIds": [
31249
]
},
{
"targetId": 219,
"targetName": "ETA receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10070,
"ligandName": "aprocitentan",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.5",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
85523
],
"refIds": [
31249
]
},
{
"targetId": 220,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10070,
"ligandName": "aprocitentan",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "5.5",
"affinityParameter": "pA2",
"dataPointInteractionIds": [
89504
],
"refIds": [
31249
]
},
{
"targetId": 220,
"targetName": "ETB receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10070,
"ligandName": "aprocitentan",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "6.0",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
85524
],
"refIds": [
31249
]
},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 10100,
"ligandName": "vibegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.1",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
85600
],
"refIds": [
36239
]
},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Dog",
"primaryTarget": false,
"ligandId": 10100,
"ligandName": "vibegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
85601
],
"refIds": [
36239
]
},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Monkey",
"primaryTarget": false,
"ligandId": 10100,
"ligandName": "vibegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
85602
],
"refIds": [
36239
]
},
{
"targetId": 30,
"targetName": "β3-adrenoceptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 10100,
"ligandName": "vibegron",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Selective",
"affinity": "8.7 - 9.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
85599
],
"refIds": [
36239,
36240,
45320
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},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Guinea pig",
"primaryTarget": false,
"ligandId": 10102,
"ligandName": "mizolastine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.3",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
85611
],
"refIds": [
36243
]
},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 10102,
"ligandName": "mizolastine",
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"action": "Antagonist",
"selectivity": "Selective",
"affinity": "8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85610
],
"refIds": [
36242
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},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Guinea pig",
"primaryTarget": false,
"ligandId": 10103,
"ligandName": "rupatadine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85614
],
"refIds": [
36247
]
},
{
"targetId": 262,
"targetName": "H1 receptor",
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"targetSpecies": "Human",
"primaryTarget": true,
"ligandId": 10103,
"ligandName": "rupatadine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Selective",
"affinity": "8.4",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
85612
],
"refIds": [
28072
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},
{
"targetId": 334,
"targetName": "PAF receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10103,
"ligandName": "rupatadine",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "5.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85613
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"refIds": [
28072
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10129,
"ligandName": "revefenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85692
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"refIds": [
36350
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},
{
"targetId": 14,
"targetName": "M2 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10129,
"ligandName": "revefenacin",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85693
],
"refIds": [
36350
]
},
{
"targetId": 15,
"targetName": "M3 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10129,
"ligandName": "revefenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85694
],
"refIds": [
36350
]
},
{
"targetId": 16,
"targetName": "M4 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10129,
"ligandName": "revefenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85695
],
"refIds": [
36350
]
},
{
"targetId": 17,
"targetName": "M5 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10129,
"ligandName": "revefenacin",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85696
],
"refIds": [
36350
]
},
{
"targetId": 48,
"targetName": "CGRP receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10176,
"ligandName": "ubrogepant",
"type": "Antagonist",
"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "10.8",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
85820
],
"refIds": [
45081
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},
{
"targetId": 341,
"targetName": "EP2 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 10315,
"ligandName": "omidenepag",
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"action": "Agonist",
"selectivity": "Selective",
"affinity": "8.4",
"affinityParameter": "pKi",
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{
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},
{
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37855,
41511
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},
{
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86507
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37855
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},
{
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{
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},
{
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{
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86719
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38215
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},
{
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"dataPointInteractionIds": [
87043
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38716
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
87044
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38716
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},
{
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"affinityParameter": "pKi",
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87042
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38716
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},
{
"targetId": 71,
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"affinityParameter": "pIC50",
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87098
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38819
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},
{
"targetId": 44,
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"affinityParameter": "pKB",
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89500
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45080
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},
{
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"affinityParameter": "pKB",
"dataPointInteractionIds": [
87143
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45080
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},
{
"targetId": 664,
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"affinity": "",
"affinityParameter": "",
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89260
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"refIds": [
44762
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},
{
"targetId": 680,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
89346
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"refIds": [
44953
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},
{
"targetId": 665,
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"affinity": "3.7",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89265
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"refIds": [
44926
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},
{
"targetId": 671,
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"affinity": "4.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
89310
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"refIds": [
44919
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},
{
"targetId": 676,
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"ligandId": 10934,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
89343
],
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44762
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},
{
"targetId": 215,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
87396
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"refIds": [
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},
{
"targetId": 215,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
87397
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},
{
"targetId": 369,
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"affinity": "8.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
87429
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"refIds": [
38124
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},
{
"targetId": 369,
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"affinity": "7.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
87430
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38124
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},
{
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"affinity": "9.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87849
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"refIds": [
41453
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},
{
"targetId": 249,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
87850
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"refIds": [
41453
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},
{
"targetId": 659,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
91560
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"refIds": [
49729
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},
{
"targetId": 48,
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"affinity": "10.7",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
87981
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"refIds": [
41967
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},
{
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"affinity": "10.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87980
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"refIds": [
41966
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},
{
"targetId": 262,
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"affinity": "7.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
88064
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"refIds": [
42388
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},
{
"targetId": 321,
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"affinity": "8.8 - 9.3",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
89215
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"refIds": [
44839
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
88165
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"refIds": [
42598
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},
{
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"dataPointInteractionIds": [
89436
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43287
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},
{
"targetId": 321,
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"dataPointInteractionIds": [
89437
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43287
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},
{
"targetId": 322,
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"dataPointInteractionIds": [
89214
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"refIds": [
42598,
44839
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},
{
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"affinityParameter": "pKB",
"dataPointInteractionIds": [
89438
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"refIds": [
44839
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},
{
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"affinityParameter": "pKB",
"dataPointInteractionIds": [
89439
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43287
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},
{
"targetId": 215,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
88654
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"refIds": [
43584
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},
{
"targetId": 216,
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"dataPointInteractionIds": [
88655
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"refIds": [
43584
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},
{
"targetId": 262,
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"dataPointInteractionIds": [
88656
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43584
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},
{
"targetId": 249,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
88903
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"refIds": [
44102
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},
{
"targetId": 54,
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"dataPointInteractionIds": [
88963
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"refIds": [
44305
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},
{
"targetId": 261,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
88979
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"refIds": [
44318,
44319
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},
{
"targetId": 256,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
89019
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"refIds": [
44421
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},
{
"targetId": 256,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
89020
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44421
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},
{
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45086
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},
{
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},
{
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44434
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},
{
"targetId": 671,
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"dataPointInteractionIds": [
89312
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44927
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},
{
"targetId": 215,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
89217
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"refIds": [
44869,
44872
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},
{
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"affinity": "5.8 - 8.5",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90397,
90398
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"refIds": [
45309,
45309
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},
{
"targetId": 25,
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.5",
"affinityParameter": "pIC50",
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90396
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45309
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},
{
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"dataPointInteractionIds": [
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90457
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45309
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{
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},
{
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"dataPointInteractionIds": [
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90481
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"dataPointInteractionIds": [
90483
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45310
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"dataPointInteractionIds": [
89608
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45309
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},
{
"targetId": 28,
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"ligandId": 13192,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
90535
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"refIds": [
45312
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},
{
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"affinity": "7.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
91371
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"refIds": [
49224
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},
{
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"affinity": "7.6",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
91372
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"refIds": [
49224
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},
{
"targetId": 251,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
91370
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"refIds": [
49224
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},
{
"targetId": 251,
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"affinity": "8.1",
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"dataPointInteractionIds": [
91373
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"refIds": [
49224
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},
{
"targetId": 3315,
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"primaryTarget": false,
"ligandId": 14052,
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
91562
],
"refIds": [
49731
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},
{
"targetId": 675,
"targetName": "TAS2R39",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 14054,
"ligandName": "tenofovir alafenamide",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
91569
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"refIds": [
49736
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},
{
"targetId": 246,
"targetName": "ghrelin receptor",
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"targetSpecies": "Human",
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"ligandId": 14127,
"ligandName": "anamorelin",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
91671
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"refIds": [
49994
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},
{
"targetId": 356,
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"ligandId": 14237,
"ligandName": "paltusotine",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "9.6",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
91854
],
"refIds": [
50516
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},
{
"targetId": 356,
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.9",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
91855
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"refIds": [
50516
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},
{
"targetId": 318,
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"primaryTarget": true,
"ligandId": 14403,
"ligandName": "anrikefon",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "10.9",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
92040
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"refIds": [
51172
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},
{
"targetId": 321,
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"targetSpecies": "Human",
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"ligandId": 14430,
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"selectivity": "Not Determined",
"affinity": "9.0",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
92074
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"refIds": [
51274
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},
{
"targetId": 322,
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"ligandId": 14430,
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"action": "Antagonist",
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"affinity": "8.9",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
92075
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"refIds": [
51274
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}
]