target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id EP2 receptor,341,P43116,Human,PGD2,1881,,448457,CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1",BHMBVRSPMRCCGG-OUTUXVNYSA-N,Agonist,Full agonist,,yes,,,pKi,,5.0,,,,,,,,,,10462542, EP2 receptor,341,Q62928,Rat,PGD2,1881,,448457,CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1",BHMBVRSPMRCCGG-OUTUXVNYSA-N,Agonist,Full agonist,,yes,,,pKi,,5.3,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,PGE1,1882,,5280723,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1",GMVPRGQOIOIIMI-DWKJAMRDSA-N,Agonist,Full agonist,,,yes,,pKi,,8.04,,Ki,,9.1,,=,,,,8163486, EP2 receptor,341,Q62053,Mouse,PGE1,1882,,5280723,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1",GMVPRGQOIOIIMI-DWKJAMRDSA-N,Agonist,Full agonist,,yes,,,pKi,,8.0,,,,,,=,,,,9313928, EP2 receptor,341,Q62928,Rat,PGE1,1882,,5280723,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1",GMVPRGQOIOIIMI-DWKJAMRDSA-N,Agonist,Full agonist,,yes,,,pKi,,8.0,,,,,,=,,,,9537820, EP2 receptor,341,P43116,Human,PGE2,1883,,5280360,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1",XEYBRNLFEZDVAW-ARSRFYASSA-N,Agonist,Full agonist,,yes,yes,,pKi,8.3,,7.5,Ki,31.6,,5.01,=,,,,16604093|10634944|10462542, EP2 receptor,341,Q62053,Mouse,PGE2,1883,,5280360,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1",XEYBRNLFEZDVAW-ARSRFYASSA-N,Agonist,Full agonist,,yes,,,pKi,7.9,,7.4,,,,,=,,,,9313928|10746663|14607240, EP2 receptor,341,Q62928,Rat,PGE2,1883,,5280360,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1",XEYBRNLFEZDVAW-ARSRFYASSA-N,Agonist,Full agonist,,yes,,,pKi,,8.2,,,,,,=,,,,9537820, EP2 receptor,341,P43116,Human,PGF,1884,,5280363,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O,"InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1",PXGPLTODNUVGFL-YNNPMVKQSA-N,Agonist,Full agonist,,yes,,,pKi,6.0,,5.2,,,,,,,,,10634944|10462542, EP2 receptor,341,Q62928,Rat,PGF,1884,,5280363,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O,"InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1",PXGPLTODNUVGFL-YNNPMVKQSA-N,Agonist,Full agonist,,yes,,,pKi,,5.6,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,U46619,1888,,5311493,CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O,"InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1",LQANGKSBLPMBTJ-BRSNVKEHSA-N,Agonist,Full agonist,,,,,pKi,,4.9,,,,,,,,,,10634944, EP2 receptor,341,Q62928,Rat,U46619,1888,,5311493,CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O,"InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1",LQANGKSBLPMBTJ-BRSNVKEHSA-N,Agonist,Full agonist,,,,,pKi,,5.1,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,butaprost (free acid form),1892,,25886893,CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18-,20-,21+/m1/s1",PAYNQYXOKJDXAV-ZHIWTBQHSA-N,Agonist,Full agonist,,,,,pKi,7.0,,5.9,,,,,=,,,,10634944|10462542, EP2 receptor,341,Q62928,Rat,butaprost (free acid form),1892,,25886893,CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18-,20-,21+/m1/s1",PAYNQYXOKJDXAV-ZHIWTBQHSA-N,Agonist,Full agonist,,,,,pKi,,7.2,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,carbacyclin,1893,,5311242,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O,"InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,10-11,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b11-10+,15-7-/t16-,17-,18+,19-,20+/m0/s1",XZFRIPGNUQRGPI-WLPVIMDJSA-N,Agonist,Full agonist,,,,,pKi,,6.0,,,,,,,,,,10634944, EP2 receptor,341,Q62053,Mouse,carbacyclin,1893,,5311242,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O,"InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,10-11,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b11-10+,15-7-/t16-,17-,18+,19-,20+/m0/s1",XZFRIPGNUQRGPI-WLPVIMDJSA-N,Agonist,Full agonist,,,,,pKi,,5.8,,,,,,,,,,9313928, EP2 receptor,341,P43116,Human,iloprost,1895,,6435378,CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C,"InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18?,19-,20+,21+/m0/s1",HIFJCPQKFCZDDL-SGSAMSKHSA-N,Agonist,Full agonist,,,,,pKi,,5.7,,,,,,,,,,10634944, EP2 receptor,341,Q62053,Mouse,iloprost,1895,,6435378,CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C,"InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18?,19-,20+,21+/m0/s1",HIFJCPQKFCZDDL-SGSAMSKHSA-N,Agonist,Full agonist,,,,,pKi,,5.8,,,,,,,,,,9313928, EP2 receptor,341,Q62928,Rat,iloprost,1895,,6435378,CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C,"InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18?,19-,20+,21+/m0/s1",HIFJCPQKFCZDDL-SGSAMSKHSA-N,Agonist,Full agonist,,,,,pKi,,5.9,,,,,,=,,,,9537820, EP2 receptor,341,P43116,Human,AH6809,1896,,119461,CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C,"InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)",AQFFXPQJLZFABJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.9,,,,,,,,,,10634944, EP2 receptor,341,Q62053,Mouse,AH6809,1896,,119461,CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C,"InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)",AQFFXPQJLZFABJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.5,,,,,,,,,,9313928, EP2 receptor,341,Q62928,Rat,AH6809,1896,,119461,CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C,"InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)",AQFFXPQJLZFABJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.3,,,,,,,,,,9537820, EP2 receptor,341,Q62928,Rat,17-phenyl-ω-trinor-PGE2,1912,,5283068,OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O,"InChI=1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1",FOBVMYJQWZOGGJ-XYRJXBATSA-N,Agonist,Full agonist,,,,,pKi,,6.1,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,MB-28767,1913,,5311223,OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O,"InChI=1S/C22H30O5/c23-18(16-27-19-8-4-3-5-9-19)14-12-17-13-15-21(24)20(17)10-6-1-2-7-11-22(25)26/h3-5,8-9,12,14,17-18,20,23H,1-2,6-7,10-11,13,15-16H2,(H,25,26)/b14-12+/t17-,18+,20+/m0/s1",NZGFSDWJUZOAAX-KAVAACISSA-N,Agonist,Full agonist,,,,,pKi,6.0,,5.3,,,,,,,,,10634944|10462542, EP2 receptor,341,Q62928,Rat,MB-28767,1913,,5311223,OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O,"InChI=1S/C22H30O5/c23-18(16-27-19-8-4-3-5-9-19)14-12-17-13-15-21(24)20(17)10-6-1-2-7-11-22(25)26/h3-5,8-9,12,14,17-18,20,23H,1-2,6-7,10-11,13,15-16H2,(H,25,26)/b14-12+/t17-,18+,20+/m0/s1",NZGFSDWJUZOAAX-KAVAACISSA-N,Agonist,Full agonist,,,,,pKi,,5.9,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,[3H]PGE2,1916,,5280360,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1",XEYBRNLFEZDVAW-ARSRFYASSA-N,Agonist,Full agonist,,,,,pKd,7.9,,7.7,Kd,19.9,,12.5,=,,,,16604093|10634944, EP2 receptor,341,Q62053,Mouse,[3H]PGE2,1916,,5280360,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1",XEYBRNLFEZDVAW-ARSRFYASSA-N,Agonist,Full agonist,,,,,pKd,,7.7,,,,,,,,,,14699136, EP2 receptor,341,Q62928,Rat,[3H]PGE2,1916,,5280360,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O,"InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1",XEYBRNLFEZDVAW-ARSRFYASSA-N,Agonist,Full agonist,,,,,pKd,8.3,,7.8,,,,,,,,,9537820|9440134, EP2 receptor,341,Q62053,Mouse,cicaprost,1917,,5311044,CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C,"InChI=1S/C22H30O5/c1-3-4-5-6-15(2)20(23)8-7-18-19-12-16(9-10-27-14-22(25)26)11-17(19)13-21(18)24/h9,15,17-21,23-24H,3,6,10-14H2,1-2H3,(H,25,26)/b16-9+/t15-,17-,18+,19-,20+,21+/m0/s1",ARUGKOZUKWAXDS-SEWALLKFSA-N,Agonist,Full agonist,,,,,pKi,,5.9,,,,,,,,,,9313928, EP2 receptor,341,Q62053,Mouse,11-deoxy-PGE1,1925,,5283055,CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1",DPNOTBLPQOITGU-LDDQNKHRSA-N,Agonist,Full agonist,,,,,pKi,,7.3,,,,,,,,,,9313928, EP2 receptor,341,Q62928,Rat,11-deoxy-PGE1,1925,,5283055,CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O,"InChI=1S/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1",DPNOTBLPQOITGU-LDDQNKHRSA-N,Agonist,Full agonist,,,,,pKi,,7.5,,,,,,,,,,9537820, EP2 receptor,341,Q62053,Mouse,"16,16-dimethyl-PGE2",1926,,5283066,CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C,"InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1",QAOBBBBDJSWHMU-WMBBNPMCSA-N,Agonist,Full agonist,,,,,pKi,,7.8,,,,,,,,,,9313928, EP2 receptor,341,P43116,Human,AH13205,1928,,5310998,CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O,"InChI=1S/C24H36O4/c1-2-3-6-10-22(25)19-14-12-18(13-15-19)20-16-17-23(26)21(20)9-7-4-5-8-11-24(27)28/h12-15,20-22,25H,2-11,16-17H2,1H3,(H,27,28)",XMQKDOCUWFCMEJ-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.0,,,,,,,,,,10462542, EP2 receptor,341,Q62053,Mouse,AH13205,1928,,5310998,CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O,"InChI=1S/C24H36O4/c1-2-3-6-10-22(25)19-14-12-18(13-15-19)20-16-17-23(26)21(20)9-7-4-5-8-11-24(27)28/h12-15,20-22,25H,2-11,16-17H2,1H3,(H,27,28)",XMQKDOCUWFCMEJ-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.6,,,,,,,,,,9313928, EP2 receptor,341,Q62928,Rat,evatanepag,1929,,9890801,OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C,"InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)",WOHRHWDYFNWPNG-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pEC50,,9.5,,EC50,,0.3,,=,,,,19250823, EP2 receptor,341,Q62928,Rat,evatanepag,1929,,9890801,OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C,"InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)",WOHRHWDYFNWPNG-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pIC50,,7.3,,IC50,,50.1,,=,,,,19250823, EP2 receptor,341,Q62053,Mouse,rivenprost,1930,,9803828,COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O,"InChI=1S/C24H34O6S/c1-29-16-18-6-3-5-17(13-18)14-19(25)8-9-20-21(23(27)15-22(20)26)10-12-31-11-4-7-24(28)30-2/h3,5-6,8-9,13,19-22,25-26H,4,7,10-12,14-16H2,1-2H3/b9-8+/t19-,20-,21-,22-/m1/s1",FBQUXLIJKPWCAO-AZIFJQEOSA-N,Agonist,Full agonist,,,,,pKi,,6.2,,,,,,,,,,11917107, EP2 receptor,341,Q62053,Mouse,ONO-AE-248,1931,,5311229,CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC,"InChI=1S/C22H36O5/c1-4-5-8-11-17(26-2)14-15-19-18(20(23)16-21(19)27-3)12-9-6-7-10-13-22(24)25/h6,9,14-15,17-19,21H,4-5,7-8,10-13,16H2,1-3H3,(H,24,25)/b9-6-,15-14+/t17-,18+,19+,21+/m0/s1",MXDQOCKVVLKVJS-QKIVIXBWSA-N,Agonist,Full agonist,,,,,pKi,,5.4,,,,,,,,,,10746663, EP2 receptor,341,Q62053,Mouse,ONO-AE1-259,1932,,5311228,C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O,"InChI=1S/C23H35ClO4/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h2-3,5,7,10,17-21,25-26H,1,4,6,8-9,11-16H2,(H,27,28)/b5-3-,10-7+/t17-,18-,19-,20-,21+/m1/s1",XXTBGKDWFYXGDZ-KJCKJCAZSA-N,Agonist,Full agonist,,,,,pKi,,8.5,,,,,,=,,,,10746663, EP2 receptor,341,Q62053,Mouse,ONO-AE1-329,1933,,5311230,COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O,"InChI=1S/C23H32O6S2/c1-29-14-17-6-3-2-5-16(17)7-8-18(24)9-10-19-20(25)13-21(26)23(19)31-12-4-11-30-15-22(27)28/h2-3,5-6,9-10,18-20,23-25H,4,7-8,11-15H2,1H3,(H,27,28)/b10-9+/t18-,19-,20+,23+/m0/s1",BVGVPUMSPSNRRQ-CNOJNPITSA-N,Agonist,Full agonist,,,,,pKi,,5.7,,,,,,,,,,10746663, EP2 receptor,341,Q62053,Mouse,isocarbacyclin,1934,,5311244,CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O,"InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h10-12,16-20,22-23H,2-9,13-14H2,1H3,(H,24,25)/b11-10+/t16-,17-,18+,19-,20+/m0/s1",JANVYOZZTKSZGN-WCAFQOMDSA-N,Agonist,Full agonist,,,,,pKi,,6.0,,,,,,,,,,9313928, EP2 receptor,341,P43116,Human,misoprostol (free acid form),1935,,6436406,CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C,"InChI=1S/C21H36O5/c1-3-4-13-21(2,26)14-9-11-17-16(18(22)15-19(17)23)10-7-5-6-8-12-20(24)25/h9,11,16-17,19,23,26H,3-8,10,12-15H2,1-2H3,(H,24,25)/b11-9+/t16-,17-,19-,21?/m1/s1",CNWGPXZGIIOYDL-MKYGPDKMSA-N,Agonist,Full agonist,,,,,pKi,,7.5,,,,,,,,,,10634944, EP2 receptor,341,P43116,Human,misoprostol (methyl ester),1936,,5282381,CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C,"InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1",OJLOPKGSLYJEMD-URPKTTJQSA-N,Agonist,Full agonist,,,,,pKi,,5.0,,,,,,,,,,10634944, EP2 receptor,341,P43116,Human,19(R)-OH-PGE2,1947,,5283038,O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C,"InChI=1S/C20H32O6/c1-14(21)7-6-8-15(22)11-12-17-16(18(23)13-19(17)24)9-4-2-3-5-10-20(25)26/h2,4,11-12,14-17,19,21-22,24H,3,5-10,13H2,1H3,(H,25,26)/b4-2-,12-11+/t14-,15+,16-,17-,19-/m1/s1",WTJYDBMHYPQFNJ-ZUVVJKHESA-N,Agonist,Full agonist,,,,,pKi,,5.9,,,,,,,,,,8078484, EP2 receptor,341,Q62928,Rat,19(R)-OH-PGE2,1947,,5283038,O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C,"InChI=1S/C20H32O6/c1-14(21)7-6-8-15(22)11-12-17-16(18(23)13-19(17)24)9-4-2-3-5-10-20(25)26/h2,4,11-12,14-17,19,21-22,24H,3,5-10,13H2,1H3,(H,25,26)/b4-2-,12-11+/t14-,15+,16-,17-,19-/m1/s1",WTJYDBMHYPQFNJ-ZUVVJKHESA-N,Agonist,Full agonist,,,,,pKi,,6.8,,,,,,,,,,9537820, EP2 receptor,341,P43116,Human,taprenepag,5816,,18376177,OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1,"InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)",MFFBXYNKZHTCEY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pIC50,,8.0,,,,,,=,,,,21376717, EP2 receptor,341,Q62928,Rat,taprenepag,5816,,18376177,OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1,"InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)",MFFBXYNKZHTCEY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pIC50,,8.3,,,,,,=,,,,21376717, EP2 receptor,341,P43116,Human,PF-04418948,5817,,25114442,COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O,"InChI=1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)",LWJGMYMNSNVCEM-UHFFFAOYSA-N,Antagonist,Antagonist,PF-04418948 has weaker affinity at the EP2-receptor in guinea-pigs,,,,pKB,,8.3,,,,,,=,,,,21595651|22747912, EP2 receptor,341,Q62053,Mouse,PF-04418948,5817,,25114442,COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O,"InChI=1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)",LWJGMYMNSNVCEM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKB,,8.32,,,,,,=,,,,22747912, EP2 receptor,341,P43116,Human,TG4-155,5818,,5886965,COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC,"InChI=1S/C23H26N2O4/c1-16-13-18-7-5-6-8-19(18)25(16)12-11-24-22(26)10-9-17-14-20(27-2)23(29-4)21(15-17)28-3/h5-10,13-15H,11-12H2,1-4H3,(H,24,26)/b10-9+",YBHUXHFZLMFETJ-MDZDMXLPSA-N,Antagonist,Antagonist,TG4-155 also has affinity for the human DP1 receptor (pKb = 7.8),,,,pKB,,8.62,,,,,,=,,,,22323596, EP2 receptor,341,P43116,Human,compound 1 [PMID: 20080612],5819,,673766,CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1,"InChI=1S/C17H19NO4S/c1-2-21-17(20)14-11-7-4-3-5-9-13(11)23-16(14)18-15(19)12-8-6-10-22-12/h6,8,10H,2-5,7,9H2,1H3,(H,18,19)",SCIMXCMXGZZKTB-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,20080612, EP2 receptor,341,P43116,Human,treprostinil,5820,,6918140,CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O,"InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1",PAJMKGZZBBTTOY-ZFORQUDYSA-N,Agonist,Full agonist,,,,,pKi,,8.4,,,,,,=,,,,22480736|25542069, EP2 receptor,341,P43116,Human,MRE-269,5852,,9931891,OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C,"InChI=1S/C25H29N3O3/c1-19(2)28(15-9-10-16-31-18-23(29)30)22-17-26-24(20-11-5-3-6-12-20)25(27-22)21-13-7-4-8-14-21/h3-8,11-14,17,19H,9-10,15-16,18H2,1-2H3,(H,29,30)",OJQMKCBWYCWFPU-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.24,,Ki,,5800.0,,=,,,,17545310, EP2 receptor,341,P43116,Human,PF-04852946,8538,,46213069,COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O,"InChI=1S/C27H24N2O5/c1-33-23-10-8-22(9-11-23)25(30)29-15-14-27(17-29,26(31)32)18-34-24-12-6-21(7-13-24)20-4-2-19(16-28)3-5-20/h2-13H,14-15,17-18H2,1H3,(H,31,32)",MDVYCLAYSVNYDS-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKB,8.53,,8.45,KB,3.55,,2.95,=,,,,23786281, EP2 receptor,341,P43116,Human,TG7-171,8546,,91827368,CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC,"InChI=1S/C24H31N3O/c1-4-26(5-2)22-13-11-20(12-14-22)18-24(28)25-15-8-16-27-19(3)17-21-9-6-7-10-23(21)27/h6-7,9-14,17H,4-5,8,15-16,18H2,1-3H3,(H,25,28)",NBHMEDLJHJCMEZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKB,,8.57,,KB,,2.69,,=,,,,24937185, EP2 receptor,341,P43116,Human,TG6-129,9283,,1987175,CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F,"InChI=1S/C20H18FN5O3S3/c1-2-18-24-25-20(31-18)26-32(28,29)16-10-8-15(9-11-16)22-19(30)23-17(27)12-5-13-3-6-14(21)7-4-13/h3-12H,2H2,1H3,(H,25,26)(H2,22,23,27,30)/b12-5+",SYSMVOANBVDZNG-LFYBBSHMSA-N,Antagonist,Antagonist,,,,,pKB,,8.06,,KB,,8.8,,=,,,,23914286, EP2 receptor,341,P43116,Human,PGN-9856,10110,,59654860,OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F,"InChI=1S/C21H15F2NO4/c22-15-4-1-3-13(9-15)14-7-8-19(23)18(10-14)21(27)24-16-5-2-6-17(11-16)28-12-20(25)26/h1-11H,12H2,(H,24,27)(H,25,26)",HZJWJNHYKNSGAT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,8.3,,,,,,=,,,,30341781, EP2 receptor,341,P43116,Human,omidenepag,10315,,44230575,OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1,"InChI=1S/C23H22N6O4S/c30-23(31)15-25-22-6-1-4-19(27-22)17-28(34(32,33)21-5-2-11-24-14-21)16-18-7-9-20(10-8-18)29-13-3-12-26-29/h1-14H,15-17H2,(H,25,27)(H,30,31)",YHGSTSNEOJUIRN-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,8.44,,Ki,,3.6,,=,,,,29332128, EP2 receptor,341,P43116,Human,TG11-77,10603,,145996528,Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C,"InChI=1S/C23H24N6O/c1-14-10-15(2)27-21(11-14)29-23-25-12-17(13-26-23)22(30)24-9-8-18-16(3)28-20-7-5-4-6-19(18)20/h4-7,10-13,28H,8-9H2,1-3H3,(H,24,30)(H,25,26,27,29)",NZOAMVGASFFEJH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKB,,8.01,,KB,,9.7,,=,,,,31904232, EP2 receptor,341,P43116,Human,TG8-260,12520,,155128767,CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4,"InChI=1S/C21H20N4O/c1-14-17(18-4-2-3-5-19(18)25-14)10-11-23-21(26)16-8-6-15(7-9-16)20-12-22-13-24-20/h2-9,12-13,25H,10-11H2,1H3,(H,22,24)(H,23,26)",XMWMPTMQNJXLNV-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKB,,7.9,,,,,,=,,,,35187419|36654746,