target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id SOS Ras/Rac guanine nucleotide exchange factor 1,3096,Q07889,Human,BAY-293,10480,,137322663,CNCc1ccccc1c1csc(c1)[C@H](Nc1nc(C)nc2c1cc(OC)c(c2)OC)C,"InChI=1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m1/s1",WEGLOYDTDILXDA-OAHLLOKOSA-N,None,Binding,,,,,pIC50,,7.68,,IC50,,21.0,,=,Binding to SOS1 in vitro.,,,30683722, SOS Ras/Rac guanine nucleotide exchange factor 1,3096,Q07889,Human,MRTX0902,11966,,156526655,C[C@@H](Nc1nnc(C)c2c1cc(nc2)N1CCOCC1)c1cccc(C#N)c1C,"InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1",ILPWEAHQRAWJIU-OAHLLOKOSA-N,None,Binding,,,,,pKi,,8.72,,Ki,,1.9,,=,,,,35833726, SOS Ras/Rac guanine nucleotide exchange factor 1,3096,Q07889,Human,BI-3406,12061,,138911318,Cc1nc2cc(c(cc2c(n1)N[C@H](C)c1cc(cc(c1)N)C(F)(F)F)O[C@H]1CCOC1)OC,"InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4-5-32-11-17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3,(H,28,29,30)/t12-,17+/m1/s1",XVFDNRYZXDHTHT-PXAZEXFGSA-N,None,Binding,,,,,pKi,,8.01,,Ki,,9.7,,=,Binding affinity determined by SPR,,,32816843, SOS Ras/Rac guanine nucleotide exchange factor 1,3096,Q07889,Human,SOS1 PROTAC 9d,12069,,163409083,O=C(CCCCCCCCN1CCN(c2c3nc(n(c3cc(Cl)c2)Cc2cc(C)c(c(c2)C)F)N2CC3(C2)CNC3)CC1)N[C@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@H](c1ccc(cc1)c1c(ncs1)C)C)O)C(C)(C)C,"InChI=1S/C57H76ClFN10O4S/c1-36-24-40(25-37(2)49(36)59)29-69-46-27-43(58)26-45(50(46)64-55(69)67-33-57(34-67)31-60-32-57)66-22-20-65(21-23-66)19-13-11-9-8-10-12-14-48(71)63-52(56(5,6)7)54(73)68-30-44(70)28-47(68)53(72)62-38(3)41-15-17-42(18-16-41)51-39(4)61-35-74-51/h15-18,24-27,35,38,44,47,52,60,70H,8-14,19-23,28-34H2,1-7H3,(H,62,72)(H,63,71)/t38-,44+,47-,52+/m0/s1",AZBRWXRYNYEDKG-VWELVXIZSA-N,Agonist,Agonist,,,,,pKd,,7.36,,Kd,,44.0,,=,,,,30205005, SOS Ras/Rac guanine nucleotide exchange factor 1,3096,Q07889,Human,compound 37 [PMID: 36384290],12256,,165437863,Cc1nc2cc3OC[C@@H]4N(CCN(C(=O)C5(C#N)CC5)C4)c3cc2c(N[C@H](C)c2cccc(C(F)F)c2F)n1,"InChI=1S/C28H27F3N6O2/c1-15(18-4-3-5-19(24(18)29)25(30)31)33-26-20-10-22-23(11-21(20)34-16(2)35-26)39-13-17-12-36(8-9-37(17)22)27(38)28(14-32)6-7-28/h3-5,10-11,15,17,25H,6-9,12-13H2,1-2H3,(H,33,34,35)/t15-,17-/m1/s1",KKFFOOWORPUAJB-NVXWUHKLSA-N,None,Binding,,,,,pIC50,,8.3,,IC50,,5.0,,=,Inhibition of ERK phosphorylation in DLD-1 cells,,,36384290,