target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id BCL6 transcription repressor,2957,P41182,Human,compound 8c [PMID: 28760529],9671,,131801156,O=C1CCc2c(N1)ccc(c2)Nc1cc(OC2CCOCC2)c(cc1Cl)[N+](=O)[O-],"InChI=1S/C20H20ClN3O5/c21-15-10-18(24(26)27)19(29-14-5-7-28-8-6-14)11-17(15)22-13-2-3-16-12(9-13)1-4-20(25)23-16/h2-3,9-11,14,22H,1,4-8H2,(H,23,25)",RRELDGDKULRRDM-UHFFFAOYSA-N,Inhibitor,Binding,,,,,pIC50,,7.0,,IC50,,100.0,,=,In a cell-free ELISA system measuring ability to inhibit BCL6 BTB domain-NCoR interaction.,,,28760529, BCL6 transcription repressor,2957,P41182,Human,compound 8c [PMID: 28760529],9671,,131801156,O=C1CCc2c(N1)ccc(c2)Nc1cc(OC2CCOCC2)c(cc1Cl)[N+](=O)[O-],"InChI=1S/C20H20ClN3O5/c21-15-10-18(24(26)27)19(29-14-5-7-28-8-6-14)11-17(15)22-13-2-3-16-12(9-13)1-4-20(25)23-16/h2-3,9-11,14,22H,1,4-8H2,(H,23,25)",RRELDGDKULRRDM-UHFFFAOYSA-N,Inhibitor,Binding,,,,,pIC50,,6.14,,IC50,,720.0,,=,In a cell-based mammalian two-hybrid system assessing inhibition of protein-protein interaction between BCL6 BTB domain and BCoR.,,,28760529, BCL6 transcription repressor,2957,P41182,Human,FX1,9672,,131801157,OC(=O)CCN1C(=S)S/C(=C/2\C(=O)NC3C2C=C(Cl)C=C3)/C1=O,"InChI=1S/C14H11ClN2O4S2/c15-6-1-2-8-7(5-6)10(12(20)16-8)11-13(21)17(14(22)23-11)4-3-9(18)19/h1-2,5,7-8H,3-4H2,(H,16,20)(H,18,19)/b11-10-",NLLDCQPHRJHMSX-KHPPLWFESA-N,Inhibitor,Binding,,,yes,,pKd,,5.15,,Kd,,7000.0,,=,Binding of compound to BCL6 BTB domain using microscale thermophoresis.,,,27482887, BCL6 transcription repressor,2957,P41182,Human,BI-3802,11338,,131632978,CNC(=O)COc1cc2cc(ccc2n(c1=O)C)Nc1nc(ncc1Cl)N1C[C@H](C)C[C@@H](C1)C,"InChI=1S/C24H29ClN6O3/c1-14-7-15(2)12-31(11-14)24-27-10-18(25)22(29-24)28-17-5-6-19-16(8-17)9-20(23(33)30(19)4)34-13-21(32)26-3/h5-6,8-10,14-15H,7,11-13H2,1-4H3,(H,26,32)(H,27,28,29)/t14-,15+",GXTJETQFYHZHNB-GASCZTMLSA-N,None,Binding,,,,,pIC50,,8.52,,IC50,,3.0,,<,,,,28930682, BCL6 transcription repressor,2957,P41182,Human,BCL6 PROTAC 15,11778,,162366969,CN1C(=O)CCc2c1c1cc(Nc3nc(ncc3Cl)N3CCN(C[C@@H]3COCCO1)C(=O)CCC(=O)NCCCOCCOCCOc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c2,"InChI=1S/C45H52ClN9O12/c1-52-37(58)10-6-27-22-28-23-34(40(27)52)67-21-19-65-26-29-25-53(13-14-54(29)45-48-24-31(46)41(49-28)51-45)38(59)11-9-35(56)47-12-3-15-63-16-17-64-18-20-66-33-5-2-4-30-39(33)44(62)55(43(30)61)32-7-8-36(57)50-42(32)60/h2,4-5,22-24,29,32H,3,6-21,25-26H2,1H3,(H,47,56)(H,48,49,51)(H,50,57,60)/t29-,32?/m1/s1",YQWUMLVLLIWGQJ-UYEDPJPISA-N,Inhibitor,Inhibition,,,,,pIC50,,6.92,,IC50,,120.0,,=,,,,30335946, BCL6 transcription repressor,2957,P41182,Human,JNJ-65234637,12414,,156087292,ClC=1C(=NC(=CC1NC(CN2C=C(C3=C2N=C4N(C3=O)CCC4)C=5C(=C(C(=C(C(=O)N)C5)O)F)F)=O)N6[C@H](CN(CC6)C)C)F,"InChI=1S/C29H28ClF3N8O4/c1-13-10-38(2)6-7-40(13)19-9-17(22(30)26(33)36-19)35-20(42)12-39-11-16(14-8-15(27(34)44)25(43)24(32)23(14)31)21-28(39)37-18-4-3-5-41(18)29(21)45/h8-9,11,13,43H,3-7,10,12H2,1-2H3,(H2,34,44)(H,35,36,42)/t13-/m0/s1",LGAFZGSECXDYIR-ZDUSSCGKSA-N,Inhibitor,Binding,,,,,pKd,,8.3,,Kd,,5.0,,=,,,,36793435,