target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id aldo-keto reductase family 1 member B,2768,P15121,Human,tolrestat,7404,,53359,COc1ccc2c(c1C(F)(F)F)cccc2C(=S)N(CC(=O)O)C,"InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)",LUBHDINQXIHVLS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.33,,IC50,,47.0,,=,,,,10737739, aldo-keto reductase family 1 member B,2768,P15121,Human,lidorestat,7411,,157839,OC(=O)Cn1cc(c2c1cccc2)Cc1sc2c(n1)c(F)c(cc2F)F,"InChI=1S/C18H11F3N2O2S/c19-11-6-12(20)18-17(16(11)21)22-14(26-18)5-9-7-23(8-15(24)25)13-4-2-1-3-10(9)13/h1-4,6-7H,5,8H2,(H,24,25)",KYHVTMFADJNSGS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.3,,IC50,,5.0,,=,In vitro inhibition of recombinant human aldose reductase expressed in E coli.,,,15857120, aldo-keto reductase family 1 member B,2768,P15121,Human,sorbinil,7415,,337359,Fc1cc2[C@]3(CCOc2cc1)NC(=O)NC3=O,"InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1",LXANPKRCLVQAOG-NSHDSACASA-N,Inhibitor,Inhibition,,,,,pIC50,,5.27,,IC50,,5400.0,,=,,,,10882376, aldo-keto reductase family 1 member B,2768,P15121,Human,zenarestat,7418,,5724,Brc1ccc(c(c1)F)Cn1c(=O)c2ccc(cc2n(c1=O)CC(=O)O)Cl,"InChI=1S/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)",SXONDGSPUVNZLO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.0,,IC50,,9900.0,,=,In vitro inhibition of recombinant human aldehyde reductase,,,15857120, aldo-keto reductase family 1 member B,2768,P15121,Human,zopolrestat,7419,,1613,OC(=O)Cc1nn(Cc2nc3c(s2)ccc(c3)C(F)(F)F)c(=O)c2c1cccc2,"InChI=1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)",BCSVCWVQNOXFGL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,4.41,,IC50,,38600.0,,=,In vitro inhibition of recombinant human aldehyde reductase,,,15857120, aldo-keto reductase family 1 member B,2768,P15121,Human,AK198,8637,,91820714,OC(=O)COc1cc(Cl)ccc1C(=O)NCc1ccc(cc1F)N,"InChI=1S/C16H14ClFN2O4/c17-10-2-4-12(14(5-10)24-8-15(21)22)16(23)20-7-9-1-3-11(19)6-13(9)18/h1-6H,7-8,19H2,(H,20,23)(H,21,22)",GFJYPJDGRCZNDI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.89,,IC50,,1.3,,=,,,,25919404,