target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id sirtuin 1,2707,Q96EB6,Human,SRT1720,7703,,24180125,O=C(c1cnc2c(n1)cccc2)Nc1ccccc1c1cn2c(n1)scc2CN1CCNCC1,"InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33)",IASPBORHOMBZMY-UHFFFAOYSA-N,Activator,Activation,,,yes,,pEC50,,6.8,,EC50,,160.0,,=,,,,18046409, sirtuin 1,2707,Q96EB6,Human,selisistat,8100,,5113032,NC(=O)C1CCCc2c1[nH]c1c2cc(cc1)Cl,"InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)",FUZYTVDVLBBXDL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.42,,IC50,,38.0,,=,,,,16354677, sirtuin 1,2707,Q96EB6,Human,splitomicin,8101,,5269,O=C1CCc2c(O1)ccc1c2cccc1,"InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2",ISFPDBUKMJDAJH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,4.02,,IC50,,96200.0,,=,,,,20041717, sirtuin 1,2707,Q96EB6,Human,compound 17 [PMID: 23570514],8778,,71654771,O=C(c1ccc(s1)C(=O)OC(C)(C)C)NCCC1CCN(CC1)c1ncnc2c1sc(c2)C(=O)N,"InChI=1S/C24H29N5O4S2/c1-24(2,3)33-23(32)17-5-4-16(34-17)22(31)26-9-6-14-7-10-29(11-8-14)21-19-15(27-13-28-21)12-18(35-19)20(25)30/h4-5,12-14H,6-11H2,1-3H3,(H2,25,30)(H,26,31)",XZEVSGANERUOOE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.17,,IC50,,6.7,,=,,,,23570514, sirtuin 1,2707,Q96EB6,Human,SIRT1 activator 3,9514,,1882365,COCCCn1c2nc3ccccc3nc2c(c1N)C(=O)NC1CCCC1,"InChI=1S/C20H25N5O2/c1-27-12-6-11-25-18(21)16(20(26)22-13-7-2-3-8-13)17-19(25)24-15-10-5-4-9-14(15)23-17/h4-5,9-10,13H,2-3,6-8,11-12,21H2,1H3,(H,22,26)",VNOFYGGJZCEPAH-UHFFFAOYSA-N,Activator,Activation,,,,,pIC50,,6.0,,IC50,,1000.0,,<,In an enzymatic assay,,,17099246, sirtuin 1,2707,Q96EB6,Human,SRT2104,9515,,25108829,O=C(c1sc(nc1C)c1cccnc1)Nc1ccccc1c1cn2c(n1)scc2CN1CCOCC1,"InChI=1S/C26H24N6O2S2/c1-17-23(36-25(28-17)18-5-4-8-27-13-18)24(33)29-21-7-3-2-6-20(21)22-15-32-19(16-35-26(32)30-22)14-31-9-11-34-12-10-31/h2-8,13,15-16H,9-12,14H2,1H3,(H,29,33)",LAMQVIQMVKWXOC-UHFFFAOYSA-N,Activator,Activation,EC1.5 is 430nM.,,,,,,,,,,,,=,,,,,