target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id kisspeptin receptor,266,Q969F8,Human,[125I]Tyr45-kisspeptin-15,1280,,155817400,CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O,"InChI=1S/C93H126N22O23/c1-50(2)37-63(82(127)104-62(24-15-35-100-93(98)99)81(126)113-72(92(137)138)42-53-19-9-6-10-20-53)103-77(121)48-102-80(125)64(39-52-17-7-5-8-18-52)106-89(134)73(49-116)114-87(132)69(45-76(97)120)110-85(130)67(43-56-47-101-61-23-12-11-21-59(56)61)108-86(131)68(44-75(96)119)109-83(128)65(40-54-26-30-57(117)31-27-54)107-84(129)66(41-55-28-32-58(118)33-29-55)111-90(135)74-25-16-36-115(74)91(136)71(38-51(3)4)112-88(133)70(46-78(122)123)105-79(124)60(95)22-13-14-34-94/h5-12,17-21,23,26-33,47,50-51,60,62-74,101,116-118H,13-16,22,24-25,34-46,48-49,94-95H2,1-4H3,(H2,96,119)(H2,97,120)(H,102,125)(H,103,121)(H,104,127)(H,105,124)(H,106,134)(H,107,129)(H,108,131)(H,109,128)(H,110,130)(H,111,135)(H,112,133)(H,113,126)(H,114,132)(H,122,123)(H,137,138)(H4,98,99,100)/t60-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-/m0/s1",UTAAZKWWXGMSAO-IBIYWHNXSA-N,Agonist,Full agonist,,,,,pKd,,10.0,,Kd,,0.1,,=,,,,11385580, kisspeptin receptor,266,Q969F8,Human,[125I]kisspeptin-10 (human),1281,,25240297,CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O,"InChI=1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)/t41-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1",RITKWYDZSSQNJI-INXYWQKQSA-N,Agonist,Full agonist,,,,,pKd,,8.7,,Kd,,1.9,,=,,,,11457843, kisspeptin receptor,266,Q969F8,Human,[125I]kisspeptin-54 (human),1282,,,,,,Agonist,Full agonist,,,,,pKd,,10.0,,,,,,,,,,11385580, kisspeptin receptor,266,Q969F8,Human,kisspeptin-10,1283,Human,25240297,OC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CCCN=C(N)N)CC(C)C)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)CC(=O)N)CC(=O)N,"InChI=1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)/t41-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1",RITKWYDZSSQNJI-INXYWQKQSA-N,Agonist,Full agonist,,yes,,,pKi,10.4,,8.6,,,,,=,,,,11385580|11457843, kisspeptin receptor,266,Q924U1,Rat,kisspeptin-10,1283,Human,25240297,OC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CCCN=C(N)N)CC(C)C)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)CC(=O)N)CC(=O)N,"InChI=1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)/t41-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1",RITKWYDZSSQNJI-INXYWQKQSA-N,Agonist,Full agonist,,,,,pKi,,8.8,,,,,,=,,,,11457843, kisspeptin receptor,266,Q969F8,Human,kisspeptin-13,1284,Human,101134421,,,,Agonist,Full agonist,,yes,,,pKi,,8.4,,,,,,=,,,,11457843, kisspeptin receptor,266,Q924U1,Rat,kisspeptin-13,1284,Human,101134421,,,,Agonist,Full agonist,,,,,pKi,,8.7,,,,,,=,,,,11457843, kisspeptin receptor,266,Q969F8,Human,kisspeptin-14,1285,Human,,,,,Agonist,Full agonist,,yes,,,pKi,,8.8,,,,,,=,,,,11457843, kisspeptin receptor,266,Q924U1,Rat,kisspeptin-14,1285,Human,,,,,Agonist,Full agonist,,,,,pKi,,8.7,,,,,,=,,,,11457843, kisspeptin receptor,266,Q969F8,Human,kisspeptin-15,1286,,155817401,CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O,"InChI=1S/C88H123N23O23/c1-46(2)33-57(77(123)100-56(24-15-31-96-88(94)95)76(122)109-66(87(133)134)37-49-19-9-6-10-20-49)99-72(117)44-98-75(121)58(35-48-17-7-5-8-18-48)102-84(130)67(45-112)110-82(128)62(40-70(92)115)106-79(125)60(38-51-43-97-55-23-12-11-21-53(51)55)104-80(126)61(39-69(91)114)105-78(124)59(36-50-26-28-52(113)29-27-50)103-81(127)63(41-71(93)116)107-85(131)68-25-16-32-111(68)86(132)65(34-47(3)4)108-83(129)64(42-73(118)119)101-74(120)54(90)22-13-14-30-89/h5-12,17-21,23,26-29,43,46-47,54,56-68,97,112-113H,13-16,22,24-25,30-42,44-45,89-90H2,1-4H3,(H2,91,114)(H2,92,115)(H2,93,116)(H,98,121)(H,99,117)(H,100,123)(H,101,120)(H,102,130)(H,103,127)(H,104,126)(H,105,124)(H,106,125)(H,107,131)(H,108,129)(H,109,122)(H,110,128)(H,118,119)(H,133,134)(H4,94,95,96)/t54-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-/m0/s1",UPGGDOAAEKSKQI-UGPGGNGJSA-N,Agonist,Full agonist,,,,,pKi,,10.0,,,,,,=,,,,11385580, kisspeptin receptor,266,Q969F8,Human,kisspeptin-28,1287,,155817402,CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)O,"InChI=1S/C119H190N36O42/c1-9-59(6)92(117(195)155-41-17-25-84(155)118(196)197)148-98(176)65(27-31-86(122)165)135-95(173)63(18-10-34-127-119(124)125)134-103(181)73(51-158)144-101(179)70(44-62-46-126-56-130-62)140-109(187)79-20-12-35-149(79)111(189)60(7)131-102(180)72(50-157)143-99(177)68(42-57(2)3)132-89(168)48-129-106(184)78-19-11-36-150(78)112(190)67(28-32-87(123)166)138-96(174)64(26-30-85(121)164)136-107(185)80-21-13-37-151(80)113(191)76(54-161)133-90(169)47-128-94(172)71(49-156)141-105(183)74(52-159)142-97(175)66(29-33-91(170)171)137-108(186)81-22-14-38-152(81)115(193)83-24-16-40-154(83)116(194)82-23-15-39-153(82)114(192)77(55-162)146-100(178)69(43-58(4)5)139-104(182)75(53-160)145-110(188)93(61(8)163)147-88(167)45-120/h46,56-61,63-84,92-93,156-163H,9-45,47-55,120H2,1-8H3,(H2,121,164)(H2,122,165)(H2,123,166)(H,126,130)(H,128,172)(H,129,184)(H,131,180)(H,132,168)(H,133,169)(H,134,181)(H,135,173)(H,136,185)(H,137,186)(H,138,174)(H,139,182)(H,140,187)(H,141,183)(H,142,175)(H,143,177)(H,144,179)(H,145,188)(H,146,178)(H,147,167)(H,148,176)(H,170,171)(H,196,197)(H4,124,125,127)/t59-,60-,61+,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,92-,93-/m0/s1",ZVRORVZRRLARFN-PSGMQYSGSA-N,Agonist,Full agonist,,,,,pEC50,,8.8,,,,,,=,,,,11457843, kisspeptin receptor,266,Q969F8,Human,kisspeptin-54,1288,Human,,,,,Agonist,Full agonist,,yes,,,pKi,9.5,,8.8,,,,,=,,,,11385580|11457843, kisspeptin receptor,266,Q924U1,Rat,kisspeptin-54,1288,Human,,,,,Agonist,Full agonist,,,,,pKi,,8.7,,,,,,=,,,,11457843, kisspeptin receptor,266,Q969F8,Human,kisspeptin-9,1289,,155817403,CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)O,"InChI=1S/C38H61N9O15/c1-19(2)15-22(41-32(55)23(17-48)42-34(57)30(20(3)50)44-28(51)16-39)31(54)43-24(18-49)35(58)46-13-5-8-26(46)37(60)47-14-6-9-27(47)36(59)45-12-4-7-25(45)33(56)40-21(38(61)62)10-11-29(52)53/h19-27,30,48-50H,4-18,39H2,1-3H3,(H,40,56)(H,41,55)(H,42,57)(H,43,54)(H,44,51)(H,52,53)(H,61,62)/t20-,21+,22+,23+,24+,25+,26+,27+,30+/m1/s1",ANGOCTQQCKYVPZ-FTBSUAHMSA-N,Agonist,Full agonist,,,,,pKi,,7.0,,,,,,=,,,,11385580, kisspeptin receptor,266,Q969F8,Human,[125I]kisspeptin-13 (human),3792,,91970993,CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O,"InChI=1S/C78H107N21O18/c1-41(2)29-49(79)77(117)99-28-14-22-61(99)76(116)97-59(37-64(82)104)73(113)93-55(33-45-23-25-47(101)26-24-45)70(110)95-57(35-62(80)102)72(112)94-56(34-46-38-87-50-20-12-11-19-48(46)50)71(111)96-58(36-63(81)103)74(114)98-60(40-100)75(115)92-54(32-44-17-9-6-10-18-44)67(107)88-39-65(105)89-53(30-42(3)4)69(109)90-51(21-13-27-86-78(84)85)68(108)91-52(66(83)106)31-43-15-7-5-8-16-43/h5-12,15-20,23-26,38,41-42,49,51-61,87,100-101H,13-14,21-22,27-37,39-40,79H2,1-4H3,(H2,80,102)(H2,81,103)(H2,82,104)(H2,83,106)(H,88,107)(H,89,105)(H,90,109)(H,91,108)(H,92,115)(H,93,113)(H,94,112)(H,95,110)(H,96,111)(H,97,116)(H,98,114)(H4,84,85,86)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1",JIGIJNKESDREHJ-WOUDKVOTSA-N,Agonist,Full agonist,,,,,pKd,,9.7,,Kd,,0.2,,=,,,,17023533, kisspeptin receptor,266,Q969F8,Human,[125I]kisspeptin-14 (human),4013,,155817467,CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O,"InChI=1S/C82H111N21O22/c1-42(2)29-53(72(115)93-52(21-13-27-89-82(87)88)71(114)101-61(81(124)125)33-45-17-9-6-10-18-45)92-67(109)40-91-70(113)54(31-44-15-7-5-8-16-44)94-78(121)62(41-104)102-77(120)58(37-65(85)107)98-74(117)56(34-47-39-90-51-20-12-11-19-49(47)51)96-75(118)57(36-64(84)106)97-73(116)55(32-46-23-25-48(105)26-24-46)95-76(119)59(38-66(86)108)99-79(122)63-22-14-28-103(63)80(123)60(30-43(3)4)100-69(112)50(83)35-68(110)111/h5-12,15-20,23-26,39,42-43,50,52-63,90,104-105H,13-14,21-22,27-38,40-41,83H2,1-4H3,(H2,84,106)(H2,85,107)(H2,86,108)(H,91,113)(H,92,109)(H,93,115)(H,94,121)(H,95,119)(H,96,118)(H,97,116)(H,98,117)(H,99,122)(H,100,112)(H,101,114)(H,102,120)(H,110,111)(H,124,125)(H4,87,88,89)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-/m0/s1",SWQFNQZATASWSZ-HCHFQKEFSA-N,Agonist,Full agonist,,,,,,,,,,,,,=,,,,17023533, kisspeptin receptor,266,Q969F8,Human,4-fluorobenzoyl-FGLRW-NH2,4014,,,,,,Agonist,Full agonist,,,,,pEC50,,9.2,,EC50,,0.69,,=,,,,18302161, kisspeptin receptor,266,Q91V45,Mouse,[dY]1KP-10,4015,,,,,,Agonist,Full agonist,,,,,pIC50,,8.4,,IC50,,3.6,,=,,,,19934405, kisspeptin receptor,266,Q969F8,Human,TAK-448,10222,,46700761,CN=C(NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)NNC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](Cc1ccc(cc1)O)NC(=O)C)O)CC(=O)N)Cc1ccccc1)CC(C)C)N,"InChI=1S/C58H80N16O14/c1-30(2)22-42(51(82)66-40(16-11-21-63-57(61)62-5)50(81)67-41(49(60)80)25-35-28-64-39-15-10-9-14-38(35)39)70-58(88)73-72-53(84)43(23-33-12-7-6-8-13-33)69-55(86)48(31(3)75)71-52(83)44(27-47(59)79)68-54(85)46-26-37(78)29-74(46)56(87)45(65-32(4)76)24-34-17-19-36(77)20-18-34/h6-10,12-15,17-20,28,30-31,37,40-46,48,64,75,77-78H,11,16,21-27,29H2,1-5H3,(H2,59,79)(H2,60,80)(H,65,76)(H,66,82)(H,67,81)(H,68,85)(H,69,86)(H,71,83)(H,72,84)(H3,61,62,63)(H2,70,73,88)/t31-,37-,40+,41+,42+,43+,44+,45-,46+,48+/m1/s1",MWXWMWSUUYXMRA-GRKBUMBKSA-N,Agonist,Agonist,,,,,pEC50,,8.28,,EC50,,5.2,,=,,,,27589480, kisspeptin receptor,266,Q969F8,Human,[d-Tyr-14C]TAK-448,10223,,,,,,Agonist,Agonist,,,,,,,,,,,,,=,,,,30044673,