target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id proteasome 20S subunit beta 8,2408,P28062,Human,HT1042,8649,,325597,O=c1snc(o1)c1cccc(c1)[N+](=O)[O-],InChI=1S/C8H4N2O4S/c11-8-14-7(9-15-8)5-2-1-3-6(4-5)10(12)13/h1-4H,QBAZATRGWRVUFN-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,6.38,,Ki,,420.0,,=,,,,24900849, proteasome 20S subunit beta 8,2408,P28062,Human,ONX-0914,9031,,23642227,COc1ccc(cc1)C[C@@H](C(=O)N[C@H](C(=O)[C@@]1(C)CO1)Cc1ccccc1)NC(=O)[C@@H](NC(=O)CN1CCOCC1)C,"InChI=1S/C31H40N4O7/c1-21(32-27(36)19-35-13-15-41-16-14-35)29(38)34-26(18-23-9-11-24(40-3)12-10-23)30(39)33-25(28(37)31(2)20-42-31)17-22-7-5-4-6-8-22/h4-12,21,25-26H,13-20H2,1-3H3,(H,32,36)(H,33,39)(H,34,38)/t21-,25-,26-,31+/m0/s1",WQAVPPWWLLVGFK-VTNASVEKSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.0,,IC50,,100.0,,=,,,,19525961, proteasome 20S subunit beta 8,2408,P28062,Human,zetomipzomib,10409,,117607904,COc1ccc(cc1)[C@H]([C@@H](C(=O)N[C@H](C(=O)[C@@]1(C)CO1)CC1=CCCC1)NC(=O)[C@@H](NC(=O)CN1CCOCC1)C)O,"InChI=1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1",GHYOCDFICYLMRF-UTIIJYGPSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.41,,IC50,,39.0,,=,Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cells using the ProCISE ELISA.,,,30380863, proteasome 20S subunit beta 8,2408,P28063,Mouse,zetomipzomib,10409,,117607904,COc1ccc(cc1)[C@H]([C@@H](C(=O)N[C@H](C(=O)[C@@]1(C)CO1)CC1=CCCC1)NC(=O)[C@@H](NC(=O)CN1CCOCC1)C)O,"InChI=1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1",GHYOCDFICYLMRF-UTIIJYGPSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.24,,IC50,,57.0,,=,Inhibition of proteolytic activity measured in A20 (mouse B-cell lymphoma) cell lysate using the ProCISE ELISA.,,,30380863,