target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id cathepsin C,2344,P53634,Human,compound 3d [PMID: 3941405],8622,,11241135,NCC(=O)NC(Cc1ccccc1)C#N,"InChI=1S/C11H13N3O/c12-7-10(14-11(15)8-13)6-9-4-2-1-3-5-9/h1-5,10H,6,8,13H2,(H,14,15)",QLVGHFBUSGYCCG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,5.57,,Ki,,2700.0,,=,,,,3941405, cathepsin C,2344,P53634,Human,brensocatib,9412,,118253852,N#C[C@H](Cc1ccc(cc1)c1ccc2c(c1)n(C)c(=O)o2)NC(=O)[C@@H]1CNCCCO1,"InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1",AEXFXNFMSAAELR-RXVVDRJESA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.4,,IC50,,3.98,,=,In vitro enzyme assay,,,27690432, cathepsin C,2344,P97821,Mouse,brensocatib,9412,,118253852,N#C[C@H](Cc1ccc(cc1)c1ccc2c(c1)n(C)c(=O)o2)NC(=O)[C@@H]1CNCCCO1,"InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1",AEXFXNFMSAAELR-RXVVDRJESA-N,Inhibitor,Inhibition,,,,,pIC50,,7.6,,IC50,,25.1,,=,In vitro enzyme assay,,,27690432, cathepsin C,2344,P80067,Rat,brensocatib,9412,,118253852,N#C[C@H](Cc1ccc(cc1)c1ccc2c(c1)n(C)c(=O)o2)NC(=O)[C@@H]1CNCCCO1,"InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1",AEXFXNFMSAAELR-RXVVDRJESA-N,Inhibitor,Inhibition,,,,,pIC50,,7.7,,IC50,,19.9,,=,In vitro enzyme assay,,,27690432, cathepsin C,2344,P53634,Human,brensocatib,9412,,118253852,N#C[C@H](Cc1ccc(cc1)c1ccc2c(c1)n(C)c(=O)o2)NC(=O)[C@@H]1CNCCCO1,"InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1",AEXFXNFMSAAELR-RXVVDRJESA-N,Inhibitor,Inhibition,,,yes,,pKd,,8.6,,Kd,,2.5,,=,Surface plasmon resonance direct binding assay,,,27690432, cathepsin C,2344,P53634,Human,IcatCXPZ-01,11179,,66550979,CC[C@@H](C(=O)N[C@]1(C#N)C[C@@H]1c1ccc(cc1)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)C)N,"InChI=1S/C25H31N5O3S/c1-3-23(27)24(31)28-25(17-26)16-22(25)20-6-4-18(5-7-20)19-8-10-21(11-9-19)34(32,33)30-14-12-29(2)13-15-30/h4-11,22-23H,3,12-16,27H2,1-2H3,(H,28,31)/t22-,23+,25+/m1/s1",LJIOTBMDLVHTBO-CUYJMHBOSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.82,,IC50,,15.0,,=,,,,30978322,