target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id protein tyrosine kinase 2,2180,Q05397,Human,compound 30 [PMID: 23414845],7864,,70698427,Cn1ncc2c1c1cc(NCc3ccc(cc3)C(C)(C)C)ccc1N(S2(=O)=O)C,"InChI=1S/C22H26N4O2S/c1-22(2,3)16-8-6-15(7-9-16)13-23-17-10-11-19-18(12-17)21-20(14-24-25(21)4)29(27,28)26(19)5/h6-12,14,23H,13H2,1-5H3",AVFJKWOKOZKXRX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.19,,IC50,,640.0,,=,,,,23414845, protein tyrosine kinase 2,2180,Q05397,Human,ENMD-2076,7885,,16041424,CN1CCN(CC1)c1nc(/C=C/c2ccccc2)nc(c1)Nc1n[nH]c(c1)C,"InChI=1S/C21H25N7/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26)/b9-8+",BLQYVHBZHAISJM-CMDGGOBGSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.26,,IC50,,55.0,,=,,,,19320489, protein tyrosine kinase 2,2180,Q05397,Human,VS-4718,8742,,25073775,CNC(=O)c1ccccc1Nc1cc(ncc1C(F)(F)F)Nc1ccc(cc1OC)N1CCOCC1,"InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)",IGUBBWJDMLCRIK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.82,,IC50,,1.5,,=,,,,20234191, protein tyrosine kinase 2,2180,Q05397,Human,PF-562271,9381,,11713159,O=C1Nc2c(C1)cc(cc2)Nc1ncc(c(n1)NCc1cccnc1N(S(=O)(=O)C)C)C(F)(F)F,"InChI=1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30)",MZDKLVOWGIOKTN-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.82,,IC50,,1.5,,=,,,,18339875, protein tyrosine kinase 2,2180,Q05397,Human,NVP-TAE 226,9382,,9934347,CNC(=O)c1ccccc1Nc1nc(ncc1Cl)Nc1ccc(cc1OC)N1CCOCC1,"InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)",UYJNQQDJUOUFQJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.26,,IC50,,5.5,,=,,,,17219439|17431114, protein tyrosine kinase 2,2180,Q05397,Human,CEP-37440,9698,,71721648,OCCN1CCN(CC1)[C@H]1CCCc2c(C1)ccc(c2OC)Nc1ncc(c(n1)Nc1ccccc1C(=O)NC)Cl,"InChI=1S/C30H38ClN7O3/c1-32-29(40)23-7-3-4-9-25(23)34-28-24(31)19-33-30(36-28)35-26-11-10-20-18-21(6-5-8-22(20)27(26)41-2)38-14-12-37(13-15-38)16-17-39/h3-4,7,9-11,19,21,39H,5-6,8,12-18H2,1-2H3,(H,32,40)(H2,33,34,35,36)/t21-/m0/s1",BCSHRERPHLTPEE-NRFANRHFSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,,,,27527804, protein tyrosine kinase 2,2180,Q05397,Human,conteltinib,9763,,89860551,COc1cc(ccc1Nc1nc2NCCc2c(n1)Nc1ccccc1S(=O)(=O)NC(C)C)N1CCC(CC1)N1CCN(CC1)C,"InChI=1S/C32H45N9O3S/c1-22(2)38-45(42,43)29-8-6-5-7-27(29)34-31-25-11-14-33-30(25)36-32(37-31)35-26-10-9-24(21-28(26)44-4)40-15-12-23(13-16-40)41-19-17-39(3)18-20-41/h5-10,21-23,38H,11-20H2,1-4H3,(H3,33,34,35,36,37)",NPJCURIANJMFEO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.7,,IC50,,20.0,,<,In a time-resolved fluorescence (TRF) assay using recombinant GST-tagged FAK.,,,, protein tyrosine kinase 2,2180,Q05397,Human,narmafotinib,12373,,60162119,CN1CCC(CC1)c1cc(c(cc1)Nc1ncc(c(n1)CCc1ccccc1CC(=O)N)C(F)(F)F)OC,"InChI=1S/C28H32F3N5O2/c1-36-13-11-19(12-14-36)21-8-10-24(25(15-21)38-2)35-27-33-17-22(28(29,30)31)23(34-27)9-7-18-5-3-4-6-20(18)16-26(32)37/h3-6,8,10,15,17,19H,7,9,11-14,16H2,1-2H3,(H2,32,37)(H,33,34,35)",AWJVIOYPZZZYAX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,9.68,,Kd,,0.21,,=,,,,, protein tyrosine kinase 2,2180,Q05397,Human,YHJ1039,13032,,90466261,CCN1CCN(CC1)C2=CC=C(NC3=NC4=C(SC=C4C5=CC=CC(NS(C)(=O)=O)=C5)C=N3)C=C2,"InChI=1S/C25H28N6O2S2/c1-3-30-11-13-31(14-12-30)21-9-7-19(8-10-21)27-25-26-16-23-24(28-25)22(17-34-23)18-5-4-6-20(15-18)29-35(2,32)33/h4-10,15-17,29H,3,11-14H2,1-2H3,(H,26,27,28)",MQMVBXQAIMTOTQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.15,,IC50,,7.0,,=,,,,34324343,